Tissue-resident memory-like ILCs: innate counterparts of TRM cells

Wang, Xianwei; Tian, Zhigang; Peng, Hui

doi:10.1007/s13238-019-0647-7

Cited by 14 publications

(13 citation statements)

References 98 publications

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“…NK cells are important for anti-tumor and anti-viral immunity, whereas ILCs may act to promote tissue repair (Ishizuka et al, 2016;Sun and Lanier, 2011). Although innate immune cells have classically been described as having a rapid, short-lived response, studies in the past decade have shown that the function of myeloid and innate lymphoid cells can be shaped and enhanced by prior antigenic exposure through epigenetic and metabolic changes or modulation of surface receptor expression (Netea et al, 2020;O'Sullivan et al, 2015;Rodriguez et al, 2019;Sun et al, 2009;Wang et al, 2020). The adaptive immune system is characterized by its diverse repertoire of antigen-specific receptors expressed by T and B lymphocytes and ability to retain immunological memory over decades.…”

Section: Introductionmentioning

confidence: 99%

The Whole Body as the System in Systems Immunology

Poon

Farber

2020

iScience

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Summary The human immune system is comprised of a diverse and interactive network of specialized cells localized in diverse tissues throughout the body, where they mediate protection against pathogens and environmental insults while maintaining tissue homeostasis. Although much of our understanding of human immunology has derived from studies of peripheral blood, recent work utilizing human tissue resources and innovative computational methods have employed a whole-body, systems-based approach, revealing tremendous complexity and heterogeneity of the immune system within individuals and across the population. In this review, we discuss how tissue localization, developmental and age-associated changes, and conditions of health and disease shape the immune response, as well as how improved understanding of interindividual and tissue-specific immunity can be leveraged for developing targeted therapeutics.

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Section: Introductionmentioning

confidence: 99%

The Whole Body as the System in Systems Immunology

Poon

Farber

2020

iScience

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“…ILCregs exist in the gut and control intestinal inflammation via the secretion of IL-10 [21] (Table 1). Tissue-resident memory ILCs exist in the liver or lung and have adaptive features, including virus and hapten-induced memory NK cells, hapten-induced memory ILC1s, and cytokine-induced memory ILC2s [22, 23]. Accumulating evidence also suggests that tissue-resident memory ILCs might represent the innate counterparts of resident memory T (T RM ) cells owing to some common features [22].…”

Section: Introductionmentioning

confidence: 99%

Critical Roles of Balanced Innate Lymphoid Cell Subsets in Intestinal Homeostasis, Chronic Inflammation, and Cancer

Zhu

et al. 2019

Journal of Immunology Research

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Innate lymphoid cells (ILCs) comprise a recently identified subset of innate immune cells that are mainly localized to mucosa-associated tissues. Although they have not yet been fully characterized, they can generally be divided into ILC1s, ILC2s, and ILC3s. ILCs and their corresponding cytokines act as important mediators of the early stages of the immune response during inflammation, tissue repair, and the maintenance of epithelial integrity. Consequently, the dysregulation of ILC subsets might promote inflammation and cancer. Numerous studies have demonstrated that these cells play an important role in maintaining the microecological balance of the small intestine; however, their specific roles in mediating inflammation in this tissue and tumorigenesis remain unclear and controversial. In this review, we focus on recent progress that has helped to gain a better understanding of the role of ILCs in intestinal homeostasis, chronic inflammation, and cancer. Further focused research on the regulation and role of ILCs in intestinal homeostasis and pathology will help to reveal valuable diagnostic and therapeutic targets for the treatment of intestinal diseases.

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“…hILC2s, on the other hand, had the highest expression of activation receptors and exhaustion markers compared with other hILCs, suggesting that these cells were more chronically activated in bladder tumors compared with other hILCs ( p < 0.04) (Figure ; Table ). CD103 and CD69 were highly co‐expressed in hILC3s (Figure ), a characteristic of tissue‐resident innate memory cells, and non‐recirculating immune cells that reside in tumor sites 27,28 . ILC1s and ILC3s express lymphoid tissue‐homing receptors but can switch the expression of homing receptors to migrate to different tissue sites 29 .…”

Section: Resultsmentioning

confidence: 99%

Bladder tumor ILC1s undergo Th17‐like differentiation in human bladder cancer

Mukherjee¹,

Ji²,

Tan³

et al. 2021

Cancer Medicine

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Purpose Human innate lymphoid cells (hILCs) are lineage‐negative immune cells that do not express rearranged adaptive antigen receptors. Natural killer (NK) cells are hILCs that contribute to cancer defense. The role of non‐NK hILCs in cancer is unclear. Our study aimed to characterize non‐NK hILCs in bladder cancer. Experimental design Mass cytometry was used to characterize intratumoral non‐NK hILCs based on 35 parameters, including receptors, cytokines, and transcription factors from 21 muscle‐invasive bladder tumors. Model‐based clustering was performed on t‐distributed stochastic neighbor embedding (t‐SNE) coordinates of hILCs, and the association of hILCs with tumor stage was analyzed. Results Most frequent among intratumoral non‐NK hILCs were hILC1s, which were increased in higher compared with lower stage tumors. Intratumoral hILC1s were marked by Th17‐like phenotype with high RORγt, IL‐17, and IL‐22 compared to Th1 differentiation markers, including Tbet, perforin, and IFN‐γ. Compared with intratumoral hILC2s and hILC3s, hILC1s also had lower expression of activation markers (NKp30, NKp46, and CD69) and increased expression of exhaustion molecules (PD‐1 and Tim3). Unsupervised clustering identified nine clusters of bladder hILCs, which were not defined by the primary hILC subtypes 1–3. hILC1s featured in all the nine clusters indicating that intratumoral hILC1s displayed the highest phenotypic heterogeneity among all hILCs. Conclusions hILC1s are increased in higher stage tumors among patients with muscle‐invasive bladder cancer. These intratumoral hILC1s exhibit an exhausted phenotype and Th17‐like differentiation, identifying them as potential targets for immunotherapy.

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Tissue-resident memory-like ILCs: innate counterparts of TRM cells

Cited by 14 publications

References 98 publications

The Whole Body as the System in Systems Immunology

The Whole Body as the System in Systems Immunology

Critical Roles of Balanced Innate Lymphoid Cell Subsets in Intestinal Homeostasis, Chronic Inflammation, and Cancer

Bladder tumor ILC1s undergo Th17‐like differentiation in human bladder cancer

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