Tissue-resident memory T cells live off the fat of the land

Stolley, J. Michael; Masopust, David

doi:10.1038/cr.2017.49

Cited by 8 publications

(7 citation statements)

References 12 publications

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“…FABP4 and FABP5 are involved in exogenous FFA acquisition/metabolism and long-term T RM cell survival, as discussed above. 8,9,138 These results demonstrate that a large number of T RM cells remain in resolved sites of psoriasis.…”

Section: T Rm Cells In the Recurrence Of Inflammatory Skin Disordersmentioning

confidence: 58%

“…The T cellspecific deletion of the lipid transport molecules fatty-acidbinding proteins 4 and 5 (FABP4/5) impairs exogenous FFA uptake by skin CD8 + T RM cells and greatly decreases their longterm survival in vivo, while having no effect on the survival of T CM cells. 8,9 These findings suggest that Notch signaling controls the survival of T RM cells at least in part by regulating their metabolic functions.…”

Section: Survival Of T Rm Cellsmentioning

confidence: 96%

“…They express C-type lectin CD69, CD103 (an E-cadherin receptor), and CD49a depending on the T RM subset and peripheral tissues. 6 Moreover, in contrast to recirculating memory T cells, skin T RM cells show strong enhancement of genes that facilitate extracellular free fatty acid (FFA) acquisition/ metabolism and mitochondrial oxidative metabolism, [7][8][9] which suggests their prominent ability to adapt to the local skin microenvironment.…”

Section: Introductionmentioning

confidence: 99%

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Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders

Chen

Shen

2019

Cell Mol Immunol

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The skin is the largest organ of the body. The establishment of immunological memory in the skin is a crucial component of the adaptive immune response. Once naive T cells are activated by antigen-presenting cells, a small fraction of them differentiate into precursor memory T cells. These precursor cells ultimately develop into several subsets of memory T cells, including central memory T (T CM ) cells, effector memory T (T EM ) cells, and tissue resident memory T (T RM ) cells. T RM cells have a unique transcriptional profile, and their most striking characteristics are their long-term survival (longevity) and low migration in peripheral tissues, including the skin. Under physiological conditions, T RM cells that reside in the skin can respond rapidly to pathogenic challenges. However, there is emerging evidence to support the vital role of T RM cells in the recurrence of chronic inflammatory skin disorders, including psoriasis, vitiligo, and fixed drug eruption, under pathological or uncontrolled conditions. Clarifying and characterizing the mechanisms that are involved in skin T RM cells will help provide promising strategies for reducing the frequency and magnitude of skin inflammation recurrence. Here, we discuss recent insights into the generation, homing, retention, and survival of T RM cells and share our perspectives on the biological characteristics of T RM cells in the recurrence of inflammatory skin disorders.

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Section: T Rm Cells In the Recurrence Of Inflammatory Skin Disordersmentioning

confidence: 58%

Section: Survival Of T Rm Cellsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders

Chen

Shen

2019

Cell Mol Immunol

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“…T‐cell‐specific depletion of these genes leads to a defective exogenous fatty acid uptake by T RM cells thus resulting in a pronounced impairment in their long‐term survival, albeit the longevity of T CM cells remained uncompromised . This has been implicated to represent metabolic adaptation or reprogramming of T RM cells by the lipid‐rich but nutrient‐poor environment of the epidermis …”

Section: Tissue‐resident Memory T Cellsmentioning

confidence: 99%

The lymphoid cell network in the skin

et al. 2018

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Cutaneous immunity represents a crucial component of the mammalian immune response. The presence of a large array of commensal microorganisms along with a myriad of environmental stresses necessitates constant immuno-surveillance of the tissue. To achieve a perfect balance between immune-tolerance and immune-activation, the skin harbors strategically localized immune cell populations that modulate these responses. To maintain homeostasis, innate and adaptive immune cells assimilate microenvironmental cues and coordinate cellular and molecular functions in a spatiotemporal manner. The role of lymphoid cells in cutaneous immunity is gaining much appreciation due to their important roles in regulating skin health and pathology. In this review, we aim to highlight the recent advances in the field of cutaneous lymphoid biology.

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“…Regulation of immune function and inflammatory response is an important strategy for the treatment of CVMDs [20][21][22][23][24]. Increasing evidences show that tissue-resident immune cells are involved in regulating the pathophysiological processes of CVMDs [25][26][27][28]. Local tissues, such as vascular endothelium and adipose tissue, also have an important impact on the occurrence and development of CVMDs [29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Developmental endothelial locus-1 in cardiovascular and metabolic diseases: a promising biomarker and therapeutic target

Zhao

Zheng

et al. 2022

Preprint

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Cardiovascular and metabolic diseases (CVMDs) are a leading cause of death worldwide and imposes a huge socioeconomic burden on individuals and healthcare systems, underscoring the urgent need to develop new drug therapies. Developmental endothelial locus-1 (DEL-1) is a secreted multifunctional domain protein that can bind to integrins and play an important role in the occurrence and development of various diseases. Recently, DEL-1 has attracted great interest for its pharmacological role in the treatment and/or management of CVMDs. In this review, we present the current knowledge on the predictive and therapeutic role of DEL-1 in a variety of CVMDs, such as atherosclerosis, hypertension, cardiac remodeling, ischemic heart disease, obesity, and insulin resistance. Collectively, DEL-1 is a promising biomarker and therapeutic target for CVMDs.

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Tissue-resident memory T cells live off the fat of the land

Cited by 8 publications

References 12 publications

Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders

Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders

The lymphoid cell network in the skin

Developmental endothelial locus-1 in cardiovascular and metabolic diseases: a promising biomarker and therapeutic target

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