“…These include suppression of anti-tumor cytotoxic T cells, promotion of tumor cell growth, motility, invasion, intravasation, angiogenesis, and ECM deposition (Afik et al, 2016; Gocheva et al, 2010; Hughes et al, 2015; Lahmar et al, 2016; Lewis et al, 2016; Noy and Pollard, 2014; De Palma et al, 2005). Many of these functions are ascribed to the M2-polarization of TAMs, and therapeutic approaches aimed at driving TAMs toward M1-polarization have shown promise in mouse models of cancer (Georgoudaki et al, 2016; Pyonteck et al, 2013).…”