Tissue response resulting from different force magnitudes combined with corticotomy in rats

Kraiwattanapong, Kriangkrai; Samruajbenjakun, Bancha

doi:10.2319/090418-645.1

Cited by 6 publications

(5 citation statements)

References 18 publications

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“…Split mouth designs have been frequently employed in orthodontics. [32][33][34] They rely on the assumption that high agreements exist between the left and right site. However, this assumption has been rarely validated, even though comparability was suggested.…”

Section: Discussionmentioning

confidence: 99%

Automated tooth segmentation as an innovative tool to assess 3D-tooth movement and root resorption in rodents

et al. 2021

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Background Orthodontic root resorptions are frequently investigated in small animals, and micro-computed tomography (μCT) enables volumetric comparison. Despite, due to overlapping histograms from dentine and bone, accurate quantification of root resorption is challenging. The present study aims at (i) validating a novel automated approach for tooth segmentation (ATS), (ii) to indicate that matching of contralateral teeth is eligible to assess orthodontic tooth movement (OTM) and root resorption (RR), (iii) and to apply the novel approach in an animal trial performing orthodontic tooth movement. Methods The oral apparatus of three female mice were scanned with a μCT. The first molars of each jaw and animal were segmented using ATS (test) and manually (control), and contralateral volumes were compared. Agreement in root volumes and time efficiency were assessed for method validation. In another n = 14 animals, the left first upper molar was protracted for 11 days at 0.5 N, whereas the contralateral molar served as control. Following ATS, OTM and RR were estimated. Results ATS was significantly more time efficient compared to the manual approach (81% faster, P < 0.01), accurate (volume differences: − 0.01 ± 0.04 mm3), and contralateral roots had comparable volumes. Protracted molars had significantly lower root volumes (P = 0.03), whereas the amount of OTM failed to reveal linear association with RR (P > 0.05). Conclusions Within the limits of the study, it was demonstrated that the combination of ATS and registration of contralateral jaws enables measurements of OTS and associated RR in μCT scans.

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Section: Discussionmentioning

confidence: 99%

Automated tooth segmentation as an innovative tool to assess 3D-tooth movement and root resorption in rodents

et al. 2021

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“…Surgery is used to accelerate OTM, but their impact on root resorption is inconclusive. Corticotomy and corticision have effect on reduction of root resorption during the early stages of OTM, but root resorption was increased with heavy force 207 . Moreover, most surgical methods including alveolar decortication, piezocision, and MOP increase the root resorption, and the degree of root resorption is positively correlated with the degree of surgical injury [208][209][210] , which indicates that the application of these surgical methods should be thought synthetically and prudently.…”

Section: Prevention Of Root Resorptionmentioning

confidence: 96%

Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade

et al. 2021

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Nowadays, orthodontic treatment has become increasingly popular. However, the biological mechanisms of orthodontic tooth movement (OTM) have not been fully elucidated. We were aiming to summarize the evidences regarding the mechanisms of OTM. Firstly, we introduced the research models as a basis for further discussion of mechanisms. Secondly, we proposed a new hypothesis regarding the primary roles of periodontal ligament cells (PDLCs) and osteocytes involved in OTM mechanisms and summarized the biomechanical and biological responses of the periodontium in OTM through four steps, basically in OTM temporal sequences, as follows: (1) Extracellular mechanobiology of periodontium: biological, mechanical, and material changes of acellular components in periodontium under orthodontic forces were introduced. (2) Cell strain: the sensing, transduction, and regulation of mechanical stimuli in PDLCs and osteocytes. (3) Cell activation and differentiation: the activation and differentiation mechanisms of osteoblast and osteoclast, the force-induced sterile inflammation, and the communication networks consisting of sensors and effectors. (4) Tissue remodeling: the remodeling of bone and periodontal ligament (PDL) in the compression side and tension side responding to mechanical stimuli and root resorption. Lastly, we talked about the clinical implications of the updated OTM mechanisms, regarding optimal orthodontic force (OOF), acceleration of OTM, and prevention of root resorption.

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“…Some studies have shown that a 10-cN force on rat molars could produce more tooth movement and less root resorption than heavier forces. 36,37 However, some researchers consider a 25-30-cN force as appropriate to induce orthodontic tooth movement in rats. 12,38 Considering the reduction of spring force value along with tooth movement, a 30-cN force was applied in this study.…”

Section: Discussionmentioning

confidence: 99%

Micro-computed tomography evaluation of the effects of orthodontic force on immature maxillary first molars and alveolar bone mineral density of Sprague–Dawley rats

Wang

Zhang

et al. 2023

Korean J Orthod

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Objective: To investigate changes in the immature teeth of Sprague-Dawley rats during orthodontic treatment and to explore the changes in the peri-radicular alveolar bone through micro-computed tomography (CT). Methods: Twentyfive 26-day-old male Sprague-Dawley rats were included. The maxillary left first molar was moved mesially under a continuous force of 30 cN, and the right first molar served as the control. After orthodontic treatment for 7, 14, 21, 28, and 42 days, the root length, tooth volume, and alveolar bone mineral density (BMD) around the mesial root were measured through micro-CT. Results: The immature teeth continued to elongate after application of orthodontic force. The root length on the force side was significantly smaller than that on the control side, whereas the differences in the volume change between both sides were not statistically significant. Alveolar bone in the coronal part of the compression and tension sides showed no difference in BMD between the experimental and control groups. The BMD of the experimental group decreased from day 14 to day 42 in the apical part of the compression side and increased from day 7 to day 42 in the apical part of the tension side. The BMD of the experimental group decreased in the root apex part on day 7. Conclusions: The root length and volume of immature teeth showed continued development under orthodontic forces. Alveolar bone resorption was observed on the compression side, and bone formation was observed on the tension side.

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Tissue response resulting from different force magnitudes combined with corticotomy in rats

Cited by 6 publications

References 18 publications

Automated tooth segmentation as an innovative tool to assess 3D-tooth movement and root resorption in rodents

Automated tooth segmentation as an innovative tool to assess 3D-tooth movement and root resorption in rodents

Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade

Micro-computed tomography evaluation of the effects of orthodontic force on immature maxillary first molars and alveolar bone mineral density of Sprague–Dawley rats

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