Tissue response to porous tantalum acetabular cups

Bobyn, J. D.; Toh, K.-K.; Hacking, S. A.; Tänzer, Michael; Krygier, Jan

doi:10.1016/s0883-5403(99)90062-1

Cited by 266 publications

(189 citation statements)

References 18 publications

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“…This material offers a low modulus of elasticity, high surface frictional characteristics, high porosity (80%), and excellent osseointegration properties (ie, bioactivity, biocompatibility, and in-growth properties) [1,4]. However, long-term followup is not yet available and the higher cost of this material has limited its widespread use [1,2,11,15,16]. We therefore asked whether in the presence of any degree of bone deficiency (1) tantalum acetabular cups with bone ingrowth capability have less chance of mechanical failure than HA-coated titanium cups which have bone ongrowth potential, (2) tantalum cups show better osteointegration with less number of lucent zones in radiographic evaluation, and (3) whether the time to failure differed between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Do Tantalum and Titanium Cups Show Similar Results in Revision Hip Arthroplasty?

Jafari

Bender

Coyle

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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Porous surfaces are intended to enhance osteointegration of cementless implants. Tantalum has been introduced in an effort to enhance osseointegration potential of uncemented components. We therefore compared the clinical outcome of acetabular components with two different porous surfaces. We retrospectively reviewed 283 patients (295 hips) who underwent cementless revision hip arthroplasty with either an HA-coated titanium cup (207 patients, 214 hips) or porous tantalum cup (79 patients, 81 hips). The minimum followup was 24 months in both groups (titanium: average 51.8 months, range, 24-98 months; tantalum: average, 35.4 months, range, 24-63 months). The titanium and tantalum groups had a mechanical failure rate (clinical plus radiographic) of 8% and 6%, respectively. In hips with minor bone deficiency (type 1, 2A, 2B using the classification of Paprosky et al.), 6% of titanium cups and 4% of tantalum cups failed. In hips with major bone deficiency (type 2C, 3), 24% of titanium cups and 12% of tantalum cups developed failure. In the major bone deficiency group, the tantalum cups had fewer numbers of lucent zones around the cup. Eighty-two percent of titanium cups that failed did so at 6 months postoperatively or later, whereas 80% of tantalum cups that failed did so in less than 6 months. Radiographically in the major group, tantalum cups yielded better fixation.

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Section: Discussionmentioning

confidence: 99%

Do Tantalum and Titanium Cups Show Similar Results in Revision Hip Arthroplasty?

Jafari

Bender

Coyle

et al. 2010

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

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“…It is 80% porous, allowing two to three times greater bony ingrowth compared with conventional porous coatings, and is considered osteoconductive [3]. Its compressive strength and elastic modulus are similar to normal bone, which theoretically reduces stress shielding and stress concentration [3][4][5]56]. Tantalum is biocompatible and its mechanical properties have been studied extensively [2,25,34,56].…”

Section: Introductionmentioning

confidence: 99%

Can Porous Tantalum Be Used to Achieve Ankle and Subtalar Arthrodesis?: A Pilot Study

Frigg

Dougall

Boyd

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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“…4 Publications or reports on pure Ta-concentrated biological responses, including in vitro bone-like apatite forming capability, 5 in vivo little adverse effects, a covering of collagen and myofibroblastic cells in foil, wire or mesh implantation in soft tissues 3 and no metallic dissolution in local, systemic, and remote organs reveal its well-behaved biocompatibility with good healing even in the course of the osseointegration process. [6][7][8] However, the insufficient mechanical strength and the minimum gap between yield and tensile strength may lead rapid and undesirable premature failure once over necking in the loading deployment, 4 which is regarded as the mainly discovered shortage for the present. Moreover, no Food and Drug Administration-approved bare Ta bulk as cardiovascular stents or vessels are in general use up to now for the serious consideration of its potential risk of enhanced recoiling and neointimal formation, even an accelerated endothelialization rate occurs with the increment of the Ta concentration as reported in literature.…”

Section: Introductionmentioning

confidence: 99%

“…9 Many ways like foaming and surface treatment were adopted to regulate the adjustment of pure Ta. 7,[10][11][12] However, much high melting point and the conceivable mismatch between surface and substrates limits the practical application of the methods mentioned above. Then, it was not until the discovery of the technique of severe plastic deformation, which was proved to be an economical and feasible way onto pure Ta due to its good workability, would the problematic issues of improvement on the microstructure together with the performances be solved perfectly even free from the interface dilemma.…”

Section: Introductionmentioning

confidence: 99%

Microstructures, mechanical behavior, cellular response, and hemocompatibility of bulk ultrafine‐grained pure tantalum

et al. 2013

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Bulk ultrafine-grained (UFG) pure Ta had been successfully prepared by equal channel angular pressing (ECAP) technique till eight passes. The 1st, 2nd, 4th, and 8th ECAPed Ta samples were investigated in the current study, with the 0th ECAPed Ta sample as the microcrystalline counterpart control. The microstructure and grain size distribution were characterized by X-ray diffractometer patterns, scanning electron microscopy, and transmission electron microscopy analysis by means of histogram. Although the mechanical behavior of all the experimental samples were analyzed through uniaxial tensile measurement and microhardness test, in vitro biological interactions onto the substrates such as protein adsorption, cellular responses derived from different types of cell lines, and the activity of erythrocyte and platelets were further evaluated and specifically assessed by bicinchoninic acid assay, enzyme-linked immunosorbent assay, and the method of colorimetric reading. A superior percentage of protein adsorption can be observed on the substrate of the UFG 8th ECAPed Ta (around 90%), even above those on the tissue culture plate (control) and the other ECAPed Ta samples. Furthermore, the UFG 8th ECAPed Ta shows no cytotoxic within 4 days culture when incubated with the murine fibroblast cell lines (L929). In addition, a priority order in the growth of endothelial cells (ECV304) other than vascular smooth muscle cells was observed in the case of the UFG 8th ECAPed Ta. In terms of hemolysis rate and adhered platelets (both the amount and the individual morphology), an evolutionary outcome of preferentially enhanced hemocompatibility can be concluded for the case of the UFG 8th ECAPed Ta.

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Tissue response to porous tantalum acetabular cups

Cited by 266 publications

References 18 publications

Do Tantalum and Titanium Cups Show Similar Results in Revision Hip Arthroplasty?

Do Tantalum and Titanium Cups Show Similar Results in Revision Hip Arthroplasty?

Can Porous Tantalum Be Used to Achieve Ankle and Subtalar Arthrodesis?: A Pilot Study

Microstructures, mechanical behavior, cellular response, and hemocompatibility of bulk ultrafine‐grained pure tantalum

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