Tissue sampling for biliary strictures using novel elbow biopsy forceps

Abstract

We aim to evaluate the safety and feasibility of novel elbow biopsy forceps with a prebent head for sampling biliary strictures in our institution. A total of 24 patients (15 males and 9 females) with biliary stricture who underwent biliary biopsy during endoscopic retrograde cholangiopancreatography (ERCP) using novel elbow biopsy forceps from June 2019 to August 2020 were retrospectively included. The novel biopsy forceps had a head angulation of 30 degrees and were able to cannulate the bile duct and approach the biliary strictures easily to obtain adequate samples. The technical success rate, incidence of adverse events, and consistency of pathological and surgical specimens were assessed. This device was used successfully in all patients. A total of 52 biopsy specimens were obtained from 24 patients, and all specimens could be used for histopathological examination. Seventeen patients were diagnosed with malignancy based on biopsies, and all of them underwent surgical treatment. The histopathological findings of the biopsy specimens were in accordance with the postoperative pathology diagnoses. One of the seven patients was diagnosed with a benign lesion that was proven to be malignant during surgical treatment in the follow-up period. Two patients experienced a single episode of acute pancreatitis and recovered shortly after appropriate treatment. No patients experienced biliary perforation or biliary bleeding. Biopsy using novel elbow forceps in patients with biliary stenosis is feasible and safe. The novel device and related biopsy technique may be widely applied for biliary disease differentiation.

Improved fluoroscopy-guided biopsies in the diagnosis of indeterminate biliary strictures: a multi-center retrospective study

“…Improved fluoroscopy-guided biopsies were performed using novel elbow biopsy forceps rather than conventional biopsy forceps. The novel elbow biopsy forceps had described in our previous study 17 . In brief, it had a prebent head of 30 degrees and a wide clamp distance (7.1 mm), which could be easily inserted into the bile duct and obtain adequate tissue sampling.…”

“…Our previous study demonstrated that the safety and effectiveness of biliary tissue sampling using novel elbow biopsy forceps during ERCP 17 . We had improved the conventional fluoroscopy-guided biopsies.…”

“…The final diagnosis of BBS was confirmed by clinical follow-up in 17 cases, surgical specimens in 2 cases. The median time of the follow-up time was 13(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) months. The location of the stricture, length of the stricture, and the number of biopsies are presented in Table1.…”

Improved fluoroscopy-guided biopsies in the diagnosis of indeterminate biliary strictures: A multi-center retrospective study

“…Improved uoroscopy-guided biopsies were performed using novel elbow biopsy forceps rather than conventional biopsy forceps. The novel elbow biopsy forceps had described in our previous study 17 . In brief, It had a prebent head of 30 degrees and a wide clamp distance (7.1 mm), which could be easily inserted into the bile duct and obtain adequate tissue sampling.…”

“…Our previous study demonstrated that the safety and effectiveness of biliary tissue sampling using novel elbow biopsy forceps during ERCP 17 . We had improved the conventional uoroscopy-guided biopsies.…”