Tissue sialic acid and fibronectin levels in human prostatic cancer

Süer, Selma; Sönmez, Hüseyin; Karaaslan, İ̇rem; Baloğlu, Hüseyi̇n; Kökoğlu, Emine

doi:10.1016/0304-3835(95)04084-6

Cited by 29 publications

(18 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study revealed significantly higher concentrations of sialic acid in tissue homogenates of malignant tumours as compared to that of surrounding normal tissues. Significantly higher levels of sialic acid in tumour tissue have also been reported by various-workers (6,46). Similar observations for abnormal levels of glycoprotein constituents have been documented in tissue extracts of liver cancer (34,47).…”

Section: -71supporting

confidence: 78%

Clinical usefulness of alterations in sialic acid, sialyl transferase and sialoproteins in breast cancer

Raval

Parekh

Patel

et al. 2004

Indian J Clin Biochem

View full text Add to dashboard Cite

Sialic acid, the end moieties of the carbohydrate chains are biologically important and essential for functions of glycoconjugates and are reported to be altered in cancer patients. Two hundred and twenty five breast cancer (BC) patients, 100 patients with benign breast disease (BBD) and 100 healthy females (controls) were enrolled for the study. Eight hundred and twenty four f011ow-up samples of 225 breast carcinoma patients were also evaluated. The association of static acid forms, sialyltransferase and ~-2-6 sialoproteins levels with presence and extent as well as prognosis of breast carcinoma was studie~. Serum sialic acid forms and sialyltransferase revealed significantly elevated levels among untreated breast cancer patients as compared to the controls, patients with BBD as well as cancer patients in remission. Non-responders showed comparable levels of the markers with those found in breast cancer patients at the time of diagnosis. Higher levels of sialic acid forms at diagnosis were associated with poor prognosis. A positive correlation between serum levels of different forms of sialic acids and extent of malignant disease was observed. The changes in serum proteins with terminal a-2-6 sialic acid correlated well with alterations in the levels of sialic acid forms and sialyltransferase. Malignant tissues showed elevated levels of sialic acid and sialyltransferase as compared to surrounding normal tissues.The results suggested potential utility of these markers in evaluation of clinical outcome.

show abstract

Section: -71supporting

confidence: 78%

Clinical usefulness of alterations in sialic acid, sialyl transferase and sialoproteins in breast cancer

Raval

Parekh

Patel

et al. 2004

Indian J Clin Biochem

View full text Add to dashboard Cite

show abstract

“…We predicted that these genes are associated with carcinogenesis. For instance, fibronectin 1 plays an important role in cell adhesion, migration, and metastasis [17]. Various types of human cancer, such as breast cancer, mammary, and uterine carcinomas, are related to the overexpression of fibronectin 1.…”

Section: Discussionmentioning

confidence: 99%

Identification of Differentially Expressed Genes in Lung Tissues of Nickel-Exposed Rats Using Suppression Subtractive Hybridization

Zhang

Fan

et al. 2010

Biol Trace Elem Res

View full text Add to dashboard Cite

Occupational exposure to nickel compound, such as nickel refining, electroplating, and in conjunction with other metals, is harmful to the health, causing respiratory distress, and lung and nasal cancer. In this work, the different gene expression patterns of lung tissues from nickel-exposed rats and controls were investigated. The suppression subtractive hybridization (SSH) method was used to generate two subtracted cDNA libraries with gene transcripts differentially expressed after nickel inducing. Dot-blot hybridizations were used to confirm differential ratios of expression of obtained SSH clones. Out of 768 unique SSH clones, which were chosen randomly from the two subtraction libraries (384 of each), 319 could be verified as differentially expressed. According to blast screening and functional annotation, 28% genes in nickel-induced cDNA library were related to cell differentiation, whereas 21% in driver library were related to oxygen transport. Two novel expressed sequence tags (ESTs; NCBI Accession No. FC809414 and No. FC809411) in nickel-induced cDNA library were obtained. The genes detected in the present study are probably important genes associated with nickel-induced lung cancer.

show abstract

“…Clinical evidences indicate that FN, especially onfFN, is overexpressed in various cancer types, including breast cancer 30, 40 , prostate cancer 41, 42 , bladder cancer 43 , oral squamous cell carcinoma 44 , head and neck squamous cell carcinoma 45 , colorectal cancer 7 , and lung cancer 46 . Thus, FN may serve as an omnipresent biomarker regardless of the origins of cancer cells.…”

Section: Upregulated Fibronectin Is a Cancer Markermentioning

confidence: 99%

Targeting fibronectin for cancer imaging and therapy

2017

View full text Add to dashboard Cite

During cancer progression, the extracellular matrix (ECM) undergoes dramatic changes, which promote cancer cell migration and invasion. In the remodeled tumor ECM, fibronectin (FN) level is upregulated to assist tumor growth, progression, and invasion. FN serves as a central organizer of ECM molecules and mediates the crosstalk between the tumor microenvironment and cancer cells. Its upregulation is correlated with angiogenesis, cancer progression, metastasis, and drug resistance. A number of FN-targeting ligands have been developed for cancer imaging and therapy. Thus far, FN-targeting imaging agents have been tested for nuclear imaging, MRI, and fluorescence imaging, for tumor detection and localization. FN-targeting therapeutics, including nuclear medicine, chemotherapy drugs, cytokines, and photothermal moieties, were also developed in cancer therapy. Because of the prevalence of FN overexpression in cancer, FN targeting imaging agents and therapeutics have the promise of broad applications in the diagnosis, treatment, and image-guided interventions of many types of cancers. This review will summarize current understanding on the role of FN in cancer, discuss the design and development of FN-targeting agents, and highlight the applications of these FN-targeting agents in cancer imaging and therapy.

show abstract

Tissue sialic acid and fibronectin levels in human prostatic cancer

Cited by 29 publications

References 20 publications

Clinical usefulness of alterations in sialic acid, sialyl transferase and sialoproteins in breast cancer

Clinical usefulness of alterations in sialic acid, sialyl transferase and sialoproteins in breast cancer

Identification of Differentially Expressed Genes in Lung Tissues of Nickel-Exposed Rats Using Suppression Subtractive Hybridization

Targeting fibronectin for cancer imaging and therapy

Contact Info

Product

Resources

About