Tissue-specific distribution patterns of retinoids and didehydroretinoids in rainbow trout Oncorhynchus mykiss

Gesto, Manuel; Castro, L. Filipe C.; Reis-Henriques, M.A.; Santos, Miguel M.

doi:10.1016/j.cbpb.2011.09.006

Cited by 23 publications

(10 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…; Gesto et al . ). Additionally, VA also accumulated in muscle in the present study because ROL concentrations were elevated at the two highest dietary inclusion levels of ROL, probably as a result of costorage with lipids.…”

Section: Discussionmentioning

confidence: 97%

Establishing an upper level of intake for vitamin A in Atlantic salmon (Salmo salarL.) postsmolts

Ørnsrud¹,

Lock²,

Waagbø³

et al. 2013

Aquacult Nutr

View full text Add to dashboard Cite

The vitamin A (VA) concentration in salmon aquaculture feeds is varying and may lead to sublethal adverse effects. In this study, 135 g Atlantic salmon postsmolts were given eight diets in duplicates with 6, 12, 26, 55, 82, 112, 360 and 749 mg retinol (ROL) kg À1 for 116 days. Subsequently, fish given 6, 82 and 749 mg ROL kg À1 were transferred to a common net pen and given a standard commercial diet for further 28 weeks. Feed conversion rate, liver functionality and markers of VA homoeostasis were not negatively affected by dietary VA level, but chronic high VA intakes led to adverse effects on growth and bone health. In plasma, there was an antagonistic effect of dietary ROL on circulating 1,25 (OH) 2 vitamin D 3 (calcitriol). Moreover, a dose-response of VA on craniofacial deformities, condition factor and vertebral morphometry and mechanical strength was observed. Vertebral deformities were observed after 28 weeks on a standard diet and not immediately after the 116 days on the experimental diet. Elevated VA is a risk factor for bone deformities, and the dietary intake of VA should not exceed 37 mg ROL kg À1 body weight day À1 in Atlantic salmon postsmolts.

show abstract

Section: Discussionmentioning

confidence: 97%

Establishing an upper level of intake for vitamin A in Atlantic salmon (Salmo salarL.) postsmolts

Ørnsrud¹,

Lock²,

Waagbø³

et al. 2013

Aquacult Nutr

View full text Add to dashboard Cite

show abstract

“…Extraction of tissues was carried out as described before [21]. Briefly, tissues were homogenized in pure methanol.…”

Section: Methodsmentioning

confidence: 99%

“…HPLC methodology was similar to that described before [21]. Chromatographic equipment consisted of a Hitachi LaChrom ELITE® HPLC System (VWR International, Darmstadt, Germany), equipped with a L-2130 pump, a L-2300 column oven, a L-2200 autosampler and a L-2455 diode array detector (DAD).…”

Section: Methodsmentioning

confidence: 99%

Retinol Metabolism in the Mollusk Osilinus lineatus Indicates an Ancient Origin for Retinyl Ester Storage Capacity

et al. 2012

Self Cite

View full text Add to dashboard Cite

Although retinoids have been reported to be present and active in vertebrates and invertebrates, the presence of mechanisms for retinoid storage in the form of retinyl esters, a key feature to maintain whole-organism retinoid homeostasis, have been considered to date a vertebrate innovation. Here we demonstrate for the first time the presence of retinol and retinyl esters in an invertebrate lophotrochozoan species, the gastropod mollusk Osilinus lineatus. Furthermore, through a pharmacological approach consisting of intramuscular injections of different retinoid precursors, we also demonstrate that the retinol esterification pathway is active in vivo in this species. Interestingly, retinol and retinyl esters were only detected in males, suggesting a gender-specific role for these compounds in the testis. Females, although lacking detectable levels of retinol or retinyl esters, also have the biochemical capacity to esterify retinol, but at a lower rate than males. The occurrence of retinyl ester storage capacity, together with the presence in males and females of active retinoids, i.e., retinoic acid isomers, indicates that O. lineatus has a well developed retinoid system. Hence, the present data strongly suggest that the capacity to maintain retinoid homeostasis has arisen earlier in Bilateria evolution than previously thought.

show abstract

“…Retinoic acid has been shown to be involved in embryonic development in fish, but there is a paucity of information on the function of RARs and RXRs in fish in general including rainbow trout (Alsop et al, 2005). However, Gesto et al (2012) reported the presence of multiple isomers of retinoic acid (i.e. all-trans-, 9-cis-and 13-cis-retinoic acid) in most tissues of juvenile rainbow trout and that the liver is the main storage tissue based on high retinoid content compared to other tissues.…”

Section: Few Gene Expression Changes In Rainbow Trout Alevins After Chronic E2 and T3 Exposuresmentioning

confidence: 99%

Reproductive and thyroid endocrine axis cross-talk in rainbow trout (Oncorhynchus mykiss) alevins

Hegeman

Marlatt

2021

General and Comparative Endocrinology

View full text Add to dashboard Cite

Although numerous studies on various aspects of endocrine axes and the physiology of both juvenile and adult life stages of several teleosts exists, studies characterizing the basic functions and cross-talk of endocrine axes during early developmental stages (i.e. embryonic to early feeding fry), in particular, are limited. The goal of this study was to characterize morphological and molecular effects in rainbow trout alevins after waterborne exposures to 17β-estradiol (E2 0.0008 to 0.5 μg/L), triiodothyronine (T3; 0.52 to 65 μg/L), and various co-treatments for 21 to 23 days. Interestingly, there was no consistent evidence that E2 alone influenced growth, development or deformity rates, nor the co-treatments of 0.02 and 0.1 μg/L of E2 with up to 65 μg/L of T3. However, 13 and 65 μg/L T3 alone expedited development and caused a unique opercular deformity not previously reported. Gene expression changes were observed, but these were mainly at the highest concentrations tested. These data suggest low-level E2 does not negate abnormal growth and development caused by hyperthyroidism and examining more time points is likely required to demonstrate a stronger response profile for individual hormones and endocrine axes cross-talk.

show abstract

Tissue-specific distribution patterns of retinoids and didehydroretinoids in rainbow trout Oncorhynchus mykiss

Cited by 23 publications

References 49 publications

Establishing an upper level of intake for vitamin A in Atlantic salmon (Salmo salarL.) postsmolts

Establishing an upper level of intake for vitamin A in Atlantic salmon (Salmo salarL.) postsmolts

Retinol Metabolism in the Mollusk Osilinus lineatus Indicates an Ancient Origin for Retinyl Ester Storage Capacity

Reproductive and thyroid endocrine axis cross-talk in rainbow trout (Oncorhynchus mykiss) alevins

Contact Info

Product

Resources

About