Tissue Specific Fate of Nanomaterials by Advanced Analytical Imaging Techniques - A Review

Graham, Uschi M.; Dozier, Alan; Oberdörster, Günter; Yokel, Robert A.; Molina, Ramon M.; Brain, Joseph D.; Pinto, Jayant M.; Weuve, Jennifer; Bennett, David A.

doi:10.1021/acs.chemrestox.0c00072

Cited by 19 publications

(17 citation statements)

References 89 publications

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“…In addition, a search into the fate of oxidic nickel nanoparticles deposited in the lung and translocated to secondary organs needs to be considered. Specifically, future work can investigate what happens to NiO nanoparticles at a subcellular level when interacting with cell organelles, proteins and fluids, such as using high-resolution analytical scanning transmission electron microscopy coupled with electron energy loss spectroscopy analysis [ 103 ].…”

Section: Discussionmentioning

confidence: 99%

Review and Evaluation of the Potential Health Effects of Oxidic Nickel Nanoparticles

Kovochich

Lyons-Darden³

et al. 2021

Nanomaterials

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The exceptional physical and chemical properties of nickel nanomaterials have been exploited in a range of applications such as electrical conductors, batteries, and biomaterials. However, it has been suggested that these unique properties may allow for increased bioavailability, bio-reactivity, and potential adverse health effects. Thus, the purpose of this review was to critically evaluate data regarding the toxicity of oxidic nickel nanoparticles (nickel oxide (NiO) and nickel hydroxide (Ni(OH)2) nanoparticles) with respect to: (1) physico-chemistry properties; (2) nanomaterial characterization in the defined delivery media; (3) appropriateness of model system and translation to potential human effects; (4) biodistribution, retention, and clearance; (5) routes and relevance of exposure; and (6) current research data gaps and likely directions of future research. Inhalation studies were prioritized for review as this represents a potential exposure route in humans. Oxidic nickel particle size ranged from 5 to 100 nm in the 60 studies that were identified. Inflammatory responses induced by exposure of oxidic nickel nanoparticles via inhalation in rodent studies was characterized as acute in nature and only displayed chronic effects after relatively large (high concentration and long duration) exposures. Furthermore, there is no evidence, thus far, to suggest that the effects induced by oxidic nickel nanoparticles are related to preneoplastic events. There are some data to suggest that nano- and micron-sized NiO particles follow a similar dose response when normalized to surface area. However, future experiments need to be conducted to better characterize the exposure–dose–response relationship according to specific surface area and reactivity as a dose metric, which drives particle dissolution and potential biological responses.

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Section: Discussionmentioning

confidence: 99%

Review and Evaluation of the Potential Health Effects of Oxidic Nickel Nanoparticles

Kovochich

Lyons-Darden³

et al. 2021

Nanomaterials

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“…TEM-EDS analysis of root section of Imperata cylindrica showed Fe crystalline deposits with a high concentration of Fe in the root cell wall 25 . Advanced scanning transmission electron microscopy (STEM), coupled with energy electron loss spectroscopy (EELS), has been used to demonstrate the phase structure and oxidative states of nanoparticles in biological tissues 26 . Advanced STEM-EDS/EELS analysis has the capability to characterise the composition and speciation of biominerals at near nanometer scale within plant root tissue.…”

Section: Introductionmentioning

confidence: 99%

Advanced characterization of biomineralization at plaque layer and inside rice roots amended with iron- and silica-enhanced biochar

Chen

Taherymoosavi

Cheong

et al. 2021

Sci Rep

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Application of iron (Fe)- and silica (Si)-enhanced biochar compound fertilisers (BCF) stimulates rice yield by increasing plant uptake of mineral nutrients. With alterations of the nutrient status in roots, element homeostasis (e.g., Fe) in the biochar-treated rice root was related to the formation of biominerals on the plaque layer and in the cortex of roots. However, the in situ characteristics of formed biominerals at the micron and sub-micron scale remain unknown. In this study, rice seedlings (Oryza sativa L.) were grown in paddy soil treated with BCF and conventional fertilizer, respectively, for 30 days. The biochar-induced changes in nutrient accumulation in roots, and the elemental composition, distribution and speciation of the biomineral composites formed in the biochar-treated roots at the micron and sub-micron scale, were investigated by a range of techniques. Results of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) showed that biochar treatment significantly increased concentrations of nutrients (e.g., Fe, Si, and P) inside the root. Raman mapping and vibrating sample magnetometry identified biochar particles and magnetic Fe nanoparticles associated with the roots. With Fe plaque formation, higher concentrations of FeOx− and FeOxH− anions on the root surface than the interior were detected by time-of-flight secondary ionization mass spectrometry (ToF-SIMS). Analysis of data from scanning electron microscopy energy-dispersive spectroscopy (SEM-EDS), and from scanning transmission electron microscopy (STEM) coupled with EDS or energy electron loss spectroscopy (EELS), determined that Fe(III) oxide nanoparticles were accumulated in the crystalline fraction of the plaque and were co-localized with Si and P on the root surface. Iron-rich nanoparticles (Fe–Si nanocomposites with mixed oxidation states of Fe and ferritin) in the root cortex were identified by using aberration-corrected STEM and in situ EELS analysis, confirming the biomineralization and storage of Fe in the rice root. The findings from this study highlight that the deposition of Fe-rich nanocomposites occurs with contrasting chemical speciation in the Fe plaque and cortex of the rice root. This provides an improved understanding of the element homeostasis in rice with biochar-mineral fertilization.

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“…In addition to the most frequently used methods, other approaches have been used to characterize the cellular nanotoxicity recently. These methods include scanning electron microscopy [ 185 ], liquid cell transmission electron microscopy [ 186 ], atomic force microscopy [ 187 ], and hyperspectral and laser confocal microscopy applied to cell-nanoparticles interactions [ 185 ]. All these microscopic methods are very sensitive and specific, which allows for a very detailed description of the function state of the cells after nanomaterials treatment.…”

Section: Current Trends In the Evaluation Of Nanotoxicity In Vitromentioning

confidence: 99%

Detection of Oxidative Stress Induced by Nanomaterials in Cells—The Roles of Reactive Oxygen Species and Glutathione

Čapek

Roušar

2021

Molecules

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The potential of nanomaterials use is huge, especially in fields such as medicine or industry. Due to widespread use of nanomaterials, their cytotoxicity and involvement in cellular pathways ought to be evaluated in detail. Nanomaterials can induce the production of a number of substances in cells, including reactive oxygen species (ROS), participating in physiological and pathological cellular processes. These highly reactive substances include: superoxide, singlet oxygen, hydroxyl radical, and hydrogen peroxide. For overall assessment, there are a number of fluorescent probes in particular that are very specific and selective for given ROS. In addition, due to the involvement of ROS in a number of cellular signaling pathways, understanding the principle of ROS production induced by nanomaterials is very important. For defense, the cells have a number of reparative and especially antioxidant mechanisms. One of the most potent antioxidants is a tripeptide glutathione. Thus, the glutathione depletion can be a characteristic manifestation of harmful effects caused by the prooxidative-acting of nanomaterials in cells. For these reasons, here we would like to provide a review on the current knowledge of ROS-mediated cellular nanotoxicity manifesting as glutathione depletion, including an overview of approaches for the detection of ROS levels in cells.

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Tissue Specific Fate of Nanomaterials by Advanced Analytical Imaging Techniques - A Review

Cited by 19 publications

References 89 publications

Review and Evaluation of the Potential Health Effects of Oxidic Nickel Nanoparticles

Review and Evaluation of the Potential Health Effects of Oxidic Nickel Nanoparticles

Advanced characterization of biomineralization at plaque layer and inside rice roots amended with iron- and silica-enhanced biochar

Detection of Oxidative Stress Induced by Nanomaterials in Cells—The Roles of Reactive Oxygen Species and Glutathione

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