Tissue-specific functional interaction between apolipoproteins A1 and E in cold-induced adipose organ mitochondrial energy metabolism.

Xepapadaki, Eva; Zvintzou, Evangelia; Nikdima, Ioanna; Karavia, Eleni A.; Hatziri, Aikaterini; Kypreos, Kyriakos E.

doi:10.1016/j.atherosclerosis.2021.06.054

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In terms of the thermogenesis mechanism, the classical BAT mainly stimulates β3-adrenergic receptors to increase intracellular lipolysis through norepinephrine (NE) released by the sympathetic nervous system. Fatty acids are used for oxidation and they bind directly to activate UCP1, which uncouples oxidative phosphorylation and mitochondrial ATP synthesis to generate heat [30][31][32]. During this process, NE activates cyclic adenosine monophosphate (cAMP) through β3-AR on the cell membrane of the adipose tissue, and cAMP stimulates cAMP-dependent protein kinase A to phosphorylate downstream proteins, such as cAMP-responsive element-binding protein (CREB) [33].…”

Section: The Brown and Beige Adipose Tissue Characteristics Of Thermo...mentioning

confidence: 99%

Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism

Wang¹,

Qiu²,

Gan³

et al. 2022

Int. J. Biol. Sci.

View full text Add to dashboard Cite

The function of the adipose tissue is influenced by complex interactions between genetics, epigenetics, and the environment, and its dysfunction can cause a variety of metabolic diseases, such as obesity or type 2 diabetes (T2D). The beige/brown adipose tissue plays a crucial role in regulating glucose and lipid metabolism by increasing energy metabolism to generate heat. The adipose tissue thermogenic program is a complex network that involves many signaling pathways regulated by coding RNAs (cRNAs) that encode transcription factor, and non-coding RNAs (ncRNAs) including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). This article discusses factors that regulate adipose tissue thermogenesis, including cRNAs and ncRNAs, and the important role of thermogenic adipose tissue in obesity-related metabolic syndrome. Several studies have shown that some cRNAs and ncRNAs can modulate the thermogenic function of adipose tissue in different ways. This article reviews the roles of cRNAs and ncRNAs in regulating thermogenesis in the beige/brown adipose tissue and the important role of the beige/brown adipose tissue in maintaining the balance of glucose and lipid metabolism in the body.

show abstract

Section: The Brown and Beige Adipose Tissue Characteristics Of Thermo...mentioning

confidence: 99%

Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism

Wang¹,

Qiu²,

Gan³

et al. 2022

Int. J. Biol. Sci.

View full text Add to dashboard Cite

show abstract

Tissue-specific functional interaction between apolipoproteins A1 and E in cold-induced adipose organ mitochondrial energy metabolism.

Cited by 1 publication

References 0 publications

Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism

Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism

Contact Info

Product

Resources

About