Tissue‐specific insulin signaling in the regulation of metabolism and aging

Zhang, Jingjing; Liu, Feng

doi:10.1002/iub.1293

Cited by 81 publications

(67 citation statements)

References 162 publications

(203 reference statements)

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“…Being secreted by the β-pancreatic cells after nutrient ingestion, insulin constitutes the earliest introduced treatment for diabetes, discovered back in the 1920s (Shabanpoor et al 2009, El-Kaissi & Sherbeeni 2011, Zhang & Liu 2014. Worth mentioning, more is known about the effects of this drug on the male reproductive function, mainly because this hormone …”

Section: Insulinmentioning

confidence: 99%

“…The insulin signaling network is rather complex and its activation is dependent on the insulin binding to its receptors and recruitment of insulin receptor substrate, followed by the activation of two key signaling pathways, the phosphatidylinositol-3-kinase (PI3K) pathway and the mitogen-activated protein kinase pathway, through which insulin will accomplish its functions regulating a panoply of processes (Zhang & Liu 2014). Besides the role of insulin in glucose disposal, this hormone is also involved in the modulation of other processes such as cellular growth, proliferation differentiation and survival (Zhang & Liu 2014).…”

Section: Testicularmentioning

confidence: 99%

“…Besides the role of insulin in glucose disposal, this hormone is also involved in the modulation of other processes such as cellular growth, proliferation differentiation and survival (Zhang & Liu 2014).…”

Section: Testicularmentioning

confidence: 99%

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Antidiabetic therapies and male reproductive function: where do we stand?

Tavares¹,

Escada-Rebelo²,

Silva³

et al. 2018

Reproduction

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Diabetes mellitus has been increasing at alarming rates in recent years, thus jeopardizing human health worldwide. Several antidiabetic drugs have been introduced in the market to manage glycemic levels, and proven effective in avoiding, minimizing or preventing the appearance or development of diabetes mellitus-related complications. However, and despite the established association between such pathology and male reproductive dysfunction, the influence of these therapeutic interventions on such topics have been scarcely explored. Importantly, this pathology may contribute toward the global decline in male fertility, giving the increasing preponderance of diabetes mellitus in young men at their reproductive age. Therefore, it is mandatory that the reproductive health of diabetic individuals is maintained during the antidiabetic treatment. With this in mind, we have gathered the available information and made a critical analysis regarding the effects of several antidiabetic drugs on male reproductive function. Unlike insulin, which has a clear and fundamental role on male reproductive function, the other antidiabetic therapies' effects at this level seem incoherent. In fact, studies are highly controversial possibly due to the different experimental study approaches, which, in our opinion, suggests caution when it comes to prescribing such drugs to young diabetic patients. Overall, much is still to be determined and further studies are needed to clarify the safety of these antidiabetic strategies on male reproductive system. Aspects such as the effects of insulin levels variations, consequent of insulin therapy, as well as what will be the impact of the side effect hypoglycemia, common to several therapeutic strategies discussed, on the male reproductive system are still to be addressed.Reproduction (2018) 155 R13-R37

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Section: Insulinmentioning

confidence: 99%

Section: Testicularmentioning

confidence: 99%

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Antidiabetic therapies and male reproductive function: where do we stand?

Tavares¹,

Escada-Rebelo²,

Silva³

et al. 2018

Reproduction

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“…Red skeletal muscles are the major site of insulin-stimulated glucose disposal (for review see 24 Thus, it might be expected that red muscles contain the highest concentrations of proteins involved in insulin-dependent incorporation of glucose transporters into a cell membrane. Our studies, however, did not show a significant elevation of titers of these proteins, except Tbc1d4 (previously known as AS160) (Figure 3).…”

mentioning

confidence: 99%

Proteomics Unveils Fibroblast–Cardiomyocyte Lactate Shuttle and Hexokinase Paradox in Mouse Muscles

Rakus¹,

Gizak²,

Wiśniewski

2016

J. Proteome Res.

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Quantitative mapping, given in biochemically interpretable units such as mol per mg of total protein, of tissue-specific proteomes is prerequisite for the analysis of any process in cells. We applied label- and standard-free proteomics to characterize three types of striated muscles: white, red, and cardiac muscle. The analysis presented here uncovers several unexpected and novel features of striated muscles. In addition to differences in protein expression levels, the three muscle types substantially differ in their patterns of basic metabolic pathways and isoforms of regulatory proteins. Importantly, some of the conclusions drawn on the basis of our results, such as the potential existence of a "fibroblast-cardiomyocyte lactate shuttle" and the "hexokinase paradox" point to the necessity of reinterpretation of some basic aspects of striated muscle metabolism. The data presented here constitute a powerful database and a resource for future studies of muscle physiology and for the design of pharmaceutics for the treatment of muscular disorders.

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“…APPL1 forms a complex with IRS-1/2 under basal conditions, which can recruit to IR after insulin-or adiponectin-stimulated APPL1 phosphorylation and then lead to the activation PI3K and MAPK pathways [42,43] (Fig. 1).…”

Section: Insulin Signaling Pathway In Brainmentioning

confidence: 98%

Cerebral insulin, insulin signaling pathway, and brain angiogenesis

Zeng

Zhang

2015

Neurol Sci

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Insulin performs unique non-metabolic functions within the brain. Broadly speaking, two major areas of these functions are those related to brain endothelial cells and the blood-brain barrier (BBB) function, and those related to behavioral effects, like cognition in disease states (Alzheimer's disease, AD) and in health. Recent studies showed that both these functions are associated with brain angiogenesis. These findings raise interesting questions such as how they are linked to each other and whether modifying brain angiogenesis by targeting certain insulin signaling pathways could be an effective strategy to treat dementia as in AD, or even to help secure healthy longevity. The two canonical downstream pathways involved in mediating the insulin signaling pathway, the phosphoinositide-3 kinase (PI3K), and mitogen-activated protein kinase (MAPK) cascades, in the brain are supposed to be similar to those in the periphery. PI3K and MAPK pathways play important roles in angiogenesis. Both are involved in stimulating hypoxia inducible factor (HIF) in angiogenesis and could be activated by the insulin signaling pathway. This suggests that PI3K and MAPK pathways might act as cross-talk between the insulin signaling pathway and the angiogenesis pathway in brain. But the cerebral insulin, insulin signaling pathway, and the detailed mechanism in the connection of insulin signaling pathway, brain angiogenesis pathway, and healthy aging or dementias are still mostly not clear and need further studies.

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Tissue‐specific insulin signaling in the regulation of metabolism and aging

Cited by 81 publications

References 162 publications

Antidiabetic therapies and male reproductive function: where do we stand?

Antidiabetic therapies and male reproductive function: where do we stand?

Proteomics Unveils Fibroblast–Cardiomyocyte Lactate Shuttle and Hexokinase Paradox in Mouse Muscles

Cerebral insulin, insulin signaling pathway, and brain angiogenesis

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