Tissue specific role of calcium sensing receptor

Abstract

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The potential of food protein‐derived anti‐inflammatory peptides against various chronic inflammatory diseases

“…NF‐ κ B is considered as a cardinal transcriptional regulator of inflammatory gene expression and it has been recently established that different forms of NF‐ κ B could have different functions in the inflammatory responses . It is also well documented that NF‐ κ B plays a crucial role in the synthesis of cytokines such as TNF‐ α , IL‐1 β , IL‐6 and IL‐8 and also regulates the expression of COX‐2 .…”

“…This review aims to discuss various molecular targets and underlying mechanisms of food protein-derived anti-inflammatory peptides and to explore their potential against various chronic inflammatory diseases.The two main pathways for chronic inflammation are the NF-B pathway and the MAPK-JNK pathway.NF-B is considered as a cardinal transcriptional regulator of inflammatory gene expression and it has been recently established that different forms of NF-B could have different functions in the inflammatory responses. 4,49 It is also well documented that NF-B plays a crucial role in the synthesis of cytokines such as J Sci Food Agric 2016; 96: 2303-2311…”

G‐CSF and cognitive dysfunction in elderly diabetic mice with cerebral small vessel disease: Preventive intervention effects and underlying mechanisms

“…The Beclin1 protein is a core element of autophagy; the post‐translational modifications of the Beclin1 interactome components include the Beclin1 protein, Bcl‐2 family, Type 3 phosphatidyl inositol 3 kinase (T3PI3K), and autophagy‐related 14 homolog (ATG14L), which is activated to produce phosphatidyl inositol‐3 kinase (PI3K). These factors are known to play important roles in the regulation of cellular autophagy, and it was recently shown that Beclin1‐mediated autophagy is involved in several neurological diseases . However, its precise role in diabetes‐induced cognitive dysfunction remains unclear.…”