2022
DOI: 10.1161/jaha.121.023348
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Tissue‐Specific Roles for the Slit–Robo Pathway During Heart, Caval Vein, and Diaphragm Development

Abstract: Background Binding of Slit ligands to their Robo receptors regulates signaling pathways that are important for heart development. Genetic variants in ROBO1 and ROBO4 have been linked to congenital heart defects in humans. These defects are recapitulated in mouse models with ubiquitous deletions of the Slit ligands or Robo receptors and include additional heart defects not currently linked to SLIT or ROBO mutations in humans. Giv… Show more

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Cited by 3 publications
(6 citation statements)
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“…Functional studies using Drosophila, zebrafish, and mouse models have reported a significant role of each Robo-Slit member in heart chamber, lumen, and valve formation [ 3 , 7 , 10 , 13 , 14 , 41 ]. Indeed, in Robo1/Robo2 and Slit3 knockout mice, the ventricular septum is absent, whereas in Slit2 mutants septum anomalies were less severe [ 14 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Functional studies using Drosophila, zebrafish, and mouse models have reported a significant role of each Robo-Slit member in heart chamber, lumen, and valve formation [ 3 , 7 , 10 , 13 , 14 , 41 ]. Indeed, in Robo1/Robo2 and Slit3 knockout mice, the ventricular septum is absent, whereas in Slit2 mutants septum anomalies were less severe [ 14 ].…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, in mice, Slit3 is the earliest gene to be expressed with a strong expression in the myocardium. It is also expressed in the outflow tract, atrial and sinus horn myocardium, cardiac neural crest, the second heart field and later in the epicardium [ 6 , 7 , 13 , 14 ]. Moreover, it has been shown that Slit3 also still expressed in the adult ventricle [ 13 , 14 ].…”
Section: Discussionmentioning
confidence: 99%
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