Tissue transglutaminase-induced down-regulation of matrix metalloproteinase-9

Inhibition of cell proliferation, migration and invasion of B16-F10 melanoma cells by α-mangostin

“…As last evidence, we observed that a-M is able to induce a reduction of MMP-9 activity, considered a prognostic marker in some human tumours [31]. Moreover, it has been demonstrated that TG inhibits significantly MMP-9 activity and expression [32]. The antimetastatic potential of a-M was established also in two human melanoma cell lines.…”

Transglutaminase 2 modulates antigen-specific antibody response by suppressing Blimp-1 and AID expression of B cells in mice

“…Sometimes, TG2 cross-links a transcription factor, for example, Sp1 in alcoholic steatohepatitis model, leading to down-regulation of hepatocyte growth factor, c-Met [39]. Or it interacts with c-Jun and inhibits dimer formation of c-Jun with c-Fos, thus lowers the activity of AP1 in TG2-transfected H9c2 cells, and resultantly down-regulates the expression of matrix metalloproteinase-9 [40]. In an ischemic stroke model, TG2 inhibits the up-regulation of VEGF and Noxa by binding with hypoxia inducible factor 1␤.…”

Activation of transglutaminase type 2 for aortic wall protection in a rat abdominal aortic aneurysm formation

“…[29][30][31] This suggests that TIMPs can be activated as a compensatory or protective reaction in response to the MMPs activation during AAA formation. Currently, Ahn et al 32 have reported that TG2 downregulates MMP-9 mRNA, protein, and activity levels in vitro experiments. Ientile et al 11 suggested that various stimuli or insults are able to induce TG2 activation following cell stress and injury.…”