Tissues and bone adhesives—historical aspects

Donkerwolcke, M; Burny, Franz Léon; Muster, D.

doi:10.1016/s0142-9612(98)00059-3

Cited by 156 publications

(133 citation statements)

References 23 publications

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“…So werden Polymethylmethacrylat (PMMA) und Cyanoacrylaten zwar gute Klebeeigenschaften zugeschrieben [4,5,9], während eine Biodegradation von PMMA jedoch überhaupt nicht stattfindet, sind die Ergebnisse bei Cyanoacrylaten uneinheitlich. Hier wird sowohl über eine kurzfristige komplette Resorption berichtet [2,13], als auch über einen Verbleib des Materials im Gewebe bis zu 2 Jahren [16].…”

Section: Diskussionunclassified

“…Erneute Eingriffe zur Metallentfernung mit den allgemeinen (Blutung, Infektion, Thrombose und Embolie) und speziellen (Osteitits, Re-Fraktur, präparationsbedingte Nervenund Gefäßverletzungen) Risiken könnten vermieden werden. Voraussetzung hierfür wäre eine rasch eintretende Stabilität der Verbindung gegenüber verschiedenen Belastungen wie Biegungs-, Scher-und Zugkräften, sowie idealerweise eine Förderung der Knochenheilung nach beginnender Degradation des Knochenklebstoffes [4]. In diesem Sinne verspricht die Anreicherung eines Knochenklebstoffs mit beta-Tricalciumphosphat (β-TCP) einen Fortschritt in der biologischen Nutzbarkeit des Werkstoffs einerseits durch Einbeziehen der osteokonduktiven Wirkung des β-TCP in die Knochenregeneration, andererseits durch die Degradation und zellulären Resorption der ansonsten kompakten Struktur des ausgehärteten Polymers.…”

Section: Introductionunclassified

See 1 more Smart Citation

Ein β-TCP angereicherter Knochenklebstoff

Kraus¹,

Pautzsch²,

Schnabelrauch³

et al. 2008

BIOmaterialien

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Section: Diskussionunclassified

Section: Introductionunclassified

Ein β-TCP angereicherter Knochenklebstoff

Kraus¹,

Pautzsch²,

Schnabelrauch³

et al. 2008

BIOmaterialien

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“…Traction and fixation of soft tissue flaps in facial plastic surgery is performed by means of soft tissue fixation methods, the most common being sutures, screws (metallic or absorbable), and surgical adhesives [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

“…Long chains confer less toxicity than do short chains. Cyanoacrylates thus demonstrate slow degradation in cyanoacetate and formaldehyde, limiting the accumulation of toxic byproducts that must be eliminated by the organism [8][9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Comparative study of tissue reactivity to n-butyl-2-cyanoacrylate and nylon monofilament thread on pericranium-cutaneous flaps in rats

Cavazana

Ioshii

Cuman³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To study the repair of pericranium-cutaneous flaps fixed with suture anchored in a skull bone tunnel or N-butyl-2-cyanoacrylate adhesive in Wistar rats with emphasis on the cellular inflammatory response and the production of types I and III collagen. METHODS:The operated region in the cephalic region of Wistar rats was removed minutes before euthanasia, fixed in formalin, and subjected to histological preparation. Slides were stained with hematoxylin-eosin and Picrosirius. Standardized counts of polymorphonuclear and mononuclear cells, fibroblasts, and macrophages were performed, and the percentages of types I and III collagen were determined. Data collection occurred on days 3, 7, 14, 21, and 45 postoperatively. A value of p<0.05 was considered statistically significant. RESULTS:Quantitative analysis of the data showed more fibroblasts in the surgical adhesive group than in the nylon monofilament thread groups (p=0.0211). Qualitative analysis showed higher reactivity in the adhesive group, with a predominance of polymorphonuclear cells from days 3−45 and macrophages from days 3−7. The amount of type I collagen exceeded 80% in the treated and control groups at the end of the experiment. CONCLUSIONS:Subperiosteal detachment triggers a cellular inflammatory response that is amplified using soft tissue fixation methods.The adhesive n-butyl-2-cyanoacrylate was more reactive than the nylon monofilament thread anchored in the skull bone tunnel.

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“…A resposta biológica dessas próteses depende da estrutura e da composição da região da superfície do polímero, o que governa a interação com as células dos organismos vivos. Além disso, essas próteses são sujeitas a deformações mecânicas, as quais podem afetar as propriedades do polímero na região da superfície [3] . Apesar das investigações das propriedades de volume dos polímeros utilizados em próteses serem comuns [4] , as propriedades mecânicas da região de superfície, onde ocorre a interação com as células, são pouco investigadas.…”

Section: Introductionunclassified

Aplicação de indentação instrumentada na caracterização mecânica de poliuretana derivada de óleo de mamona

et al. 2009

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Resumo: Neste trabalho são investigadas as propriedades mecânicas de poliuretana derivada do óleo de mamona, utilizando a técnica de indentação instrumentada com penetradores de geometrias piramidal e esférica. Foi analisada a influência da forma do penetrador utilizado nos ensaios de indentação instrumentada para se obter valores das propriedades mecânicas de polímero derivado de óleo de mamona. Os penetradores utilizados são de pontas piramidais dos tipos Berkovich e canto de cubo e esférico de raio igual a 150 μm em um Nanoindenter XP TM com cargas aplicadas entre 1 e 200 mN. As penetrações variam de acordo com o formato do penetrador, sendo maiores para pontas agudas. A dureza e o módulo de elasticidade foram determinados, utilizando o método de Oliver e Pharr. Verificou-se que os valores medidos para a dureza são maiores para penetradores mais agudos. Os valores obtidos com a ponta piramidal Berkovich foram de 0,14 GPa para pequenas penetrações e 0,12 GPa para maiores penetrações. Já os valores obtidos com ponta canto de cubo foram 25 a 30% maiores. Isso está relacionado com os volumes das regiões que apresentam deformações plásticas elevadas, no caso de penetradores agudos comparados com os volumes das regiões que sofrem deformações viscoelásticas. A viscosidade aparente determinada, utilizando penetrador esférico em testes de força aplicada constante, é igual a (22 ± 2) × 10 12 Pa.s. Palavras-chave: Poliuretana, viscoelasticidade, indentação instrumentada, dureza, módulo de elasticidade. Instrumented Indentation Applied to The Mechanical Characterization of Polyurethane Derived From Castor OilAbstract: The mechanical properties of polyurethane derived from castor oil, obtained by instrumented indentation technique with pyramidal and spherical indenters are reported. The influence of the indenter shape on the values of mechanical properties of the polymer was investigated. The indentations were made with pyramidal Berkovich, cube corner and a spherical indenter with radius of 150 μm in a Nanoindenter XP TM . The applied loads varied between 1 and 200 mN. The penetration depth increases for acute indenters, being higher for the cube corner tip. The hardness and elastic modulus were determined using the method of Oliver and Pharr. It was found that the measured values for hardness are higher for more acute indenters. The hardness with the pyramidal Berkovich tip was 0.14 GPa for small penetrations and 0.12 GPa for higher penetration depths. The values obtained with a cube corner tip were 25 to 30% higher. This is related to the volumes of regions with high plastic deformation in the case of acute indenters compared to the volumes of regions that present viscoelastic deformation. The apparent viscosity determined using the spherical indenter, in tests with applied constant forces, is equal to (22 ± 2) × 10 12 Pa.s.

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Tissues and bone adhesives—historical aspects

Cited by 156 publications

References 23 publications

Ein β-TCP angereicherter Knochenklebstoff

Ein β-TCP angereicherter Knochenklebstoff

Comparative study of tissue reactivity to n-butyl-2-cyanoacrylate and nylon monofilament thread on pericranium-cutaneous flaps in rats

Aplicação de indentação instrumentada na caracterização mecânica de poliuretana derivada de óleo de mamona

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