Titanium and Yellow Nail Syndrome

Berglund, Fredrik

doi:10.5772/32972

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…Berglund [9] hypothesized that titanium ions are released due to the galvanic action of dental gold or amalgam through the oxidative stress of fluorides. Amalgam is an alloy of mercury and other metals used in dental fillings.…”

Section: Discussionmentioning

confidence: 99%

Role of Titanium in the Development of Yellow Nail Syndrome

Decker

Daly

Scher

2015

Skin Appendage Disord

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Yellow nail syndrome (YNS) is characterized by the triad of nail changes, lymphedema and respiratory tract involvement. Several hypotheses have been postulated to explain the findings in YNS including lymphatic drainage abnormalities along with microvasculopathy. The most recent hypothesis, proposed by Berglund and Calmark [Biol Trace Elem Res 2011;143:1-7], suggests a role of titanium dioxide in the development of YNS. This study showed elevated titanium levels (ranging from 1.1 to 170 μg/g of nail plate) in nail clippings or pieces of shed nail from 30 patients with YNS. Titanium was not found in the nails of healthy patients. Complete resolution was seen in 4 patients after removal of their titanium implants. Titanium dioxide is commonly found in cosmetics, sunscreens, medications, confectionaries and joint implants. Exposure to titanium can lead to its ions being released by galvanic action of dental gold or amalgam through the oxidative stress of fluorides. It is hypothesized that this galvanic interaction may lead to the yellow discoloration. At this point, cause and effect is speculative, but titanium may play a role in a subgroup of patients with YNS.

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Section: Discussionmentioning

confidence: 99%

Role of Titanium in the Development of Yellow Nail Syndrome

Decker

Daly

Scher

2015

Skin Appendage Disord

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“…A few studies indicate a possible connection between titanium and YNS [ 62 , 63 , 64 ]. The YNS or lymphedema associated with yellow nails is an uncommon and rare medical syndrome [ 63 ], characterized by slow nails’ growth, their yellow discoloration, lymphedema and tract involvement.…”

Section: Toxicity Of Titanium and Its Alloysmentioning

confidence: 99%

“…Moreover, fluoride-containing toothpastes and fluoride gels used for oral hygiene might exacerbate YSN. Berglund [ 62 ] has shown that titanium implants are a source of titanium ions, which are released from implants because of the galvanic action of dental gold and amalgam or oxidative reaction with fluorides [ 62 ]. Interestingly, the symptoms disappeared after stopping the galvanic reactions of titanium with other metals, and thus an exposure to titanium.…”

Section: Toxicity Of Titanium and Its Alloysmentioning

confidence: 99%

Are Titania Photocatalysts and Titanium Implants Safe? Review on the Toxicity of Titanium Compounds

et al. 2020

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Titanium and its compounds are broadly used in both industrial and domestic products, including jet engines, missiles, prostheses, implants, pigments, cosmetics, food, and photocatalysts for environmental purification and solar energy conversion. Although titanium/titania-containing materials are usually safe for human, animals and environment, increasing concerns on their negative impacts have been postulated. Accordingly, this review covers current knowledge on the toxicity of titania and titanium, in which the behaviour, bioavailability, mechanisms of action, and environmental impacts have been discussed in detail, considering both light and dark conditions. Consequently, the following conclusions have been drawn: (i) titania photocatalysts rarely cause health and environmental problems; (ii) despite the lack of proof, the possible carcinogenicity of titania powders to humans is considered by some authorities; (iii) titanium alloys, commonly applied as implant materials, possess a relatively low health risk; (iv) titania microparticles are less toxic than nanoparticles, independent of the means of exposure; (v) excessive accumulation of titanium in the environment cannot be ignored; (vi) titanium/titania-containing products should be clearly marked with health warning labels, especially for pregnant women and young children; (vi) a key knowledge gap is the lack of comprehensive data about the environmental content and the influence of titania/titanium on biodiversity and the ecological functioning of terrestrial and aquatic ecosystems.

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Nail Reactions to Poisons and Intoxicants

Adigun¹

2018

Scher and Daniel's Nails

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Titanium and Yellow Nail Syndrome

Cited by 3 publications

References 24 publications

Role of Titanium in the Development of Yellow Nail Syndrome

Role of Titanium in the Development of Yellow Nail Syndrome

Are Titania Photocatalysts and Titanium Implants Safe? Review on the Toxicity of Titanium Compounds

Nail Reactions to Poisons and Intoxicants

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