Titanium-Based alloys and composites for orthopedic implants Applications: A comprehensive review

Abd-Elaziem, Walaa; Darwish, Moustafa A.; Hamada, Atef; Daoush, Walid M.

doi:10.1016/j.matdes.2024.112850

Cited by 51 publications

(3 citation statements)

References 503 publications

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“…This capability empowers machines to discern patterns and correlations within datasets, granting them valuable technical utility. 276–280 It has rapidly evolved from being a concept in science fiction to an integral part of everyday life. It plays a fundamental role in various sectors, including self-driving cars, 281 the energy sector, 282 chemical science, 283 web chats, 284 spam filters, 285 material science, 286 and face recognition.…”

Section: Applications Of Machine Learning In the Nanosensors Fieldmentioning

confidence: 99%

Advancements in nanomaterials for nanosensors: a comprehensive review

Darwish,

Abd-Elaziem,

Elsheikh

et al. 2024

Nanoscale Adv.

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Section: Applications Of Machine Learning In the Nanosensors Fieldmentioning

confidence: 99%

Advancements in nanomaterials for nanosensors: a comprehensive review

Darwish,

Abd-Elaziem,

Elsheikh

et al. 2024

Nanoscale Adv.

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“…The hazard of bacterial infections from implantable medical devices during clinical treatment is quite difficult to avoid [1], and can even be directly described as a fatal threat to patients. Medical titanium (Ti) and its alloys have been widely recognized for the clinical application of implants in orthopedics and dentistry due to their considerable chemical inertness, favorable mechanical properties, and excellent biocompatibility [2][3][4], but the problem of bacterial infections associated with their preand post-operative periods threatens their successful operation to a great extent, and the infections frequently manifest themselves in the localized pain and postponed healing [5], which can cause additional disturbances and economic losses to the patients and their families. In the past, the utilization of antibiotics for the treatment of bacterial infections arising from implants has obtained satisfactory results, but the abuse of antibiotics has also caused a variety of negative effects, such as the emergence of bacterial drug resistance and rapid bacterial evolution and mutation, etc., which have significantly diminished the efficacy of antibiotics [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, multifunctional nanomaterials' platform has drawn tremendous attention in recent years to defend against pathogenic bacterial infections, owing to their distinctive physicochemical properties including a quantum size effect and high specific surface area, superior antibacterial efficiency, lower bacterial drug resistance, and biocompatibility [2,8]. The nanomaterials' modification of Ti implants showed promising potential for improving the antibacterial performance.…”

Section: Introductionmentioning

confidence: 99%

Polydopamine-Coated Copper-Doped Co3O4 Nanosheets Rich in Oxygen Vacancy on Titanium and Multimodal Synergistic Antibacterial Study

Qi,

Yu,

Liu

et al. 2024

Materials

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Medical titanium-based (Ti-based) implants in the human body are prone to infection by pathogenic bacteria, leading to implantation failure. Constructing antibacterial nanocoatings on Ti-based implants is one of the most effective strategies to solve bacterial contamination. However, single antibacterial function was not sufficient to efficiently kill bacteria, and it is necessary to develop multifunctional antibacterial methods. This study modifies medical Ti foils with Cu-doped Co3O4 rich in oxygen vacancies, and improves their biocompatibility by polydopamine (PDA/Cu-Ov-Co3O4). Under near-infrared (NIR) irradiation, nanocoatings can generate •OH and 1O2 due to Cu+ Fenton-like activity and a photodynamic effect of Cu-Ov-Co3O4, and the total reactive oxygen species (ROS) content inside bacteria significantly increases, causing oxidative stress of bacteria. Further experiments prove that the photothermal process enhances the bacterial membrane permeability, allowing the invasion of ROS and metal ions, as well as the protein leakage. Moreover, PDA/Cu-Ov-Co3O4 can downregulate ATP levels and further reduce bacterial metabolic activity after irradiation. This coating exhibits sterilization ability against both Escherichia coli and Staphylococcus aureus with an antibacterial rate of ca. 100%, significantly higher than that of bare medical Ti foils (ca. 0%). Therefore, multifunctional synergistic antibacterial nanocoating will be a promising strategy for preventing bacterial contamination on medical Ti-based implants.

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Modeling Mechanical Properties of Titanium Scaffolds with Variable Microporosity

Slámečka,

Skalka,

Pokluda

2024

Adv Eng Mater

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The article introduces a two‐level finite element model for metallic scaffolds with porosity at both design and material levels. Despite several additive manufacturing methods producing structures with controlled hierarchical porosity, their functional properties remain largely unknown, hindering industrial utilization. This article examines how material microporosity affects the mechanical properties of a scaffold prepared by direct ink writing from pure titanium with dimensions typical for orthopedic implants. The study focuses on the compressive response of scaffolds with microporosity ranging from 0.05 to 0.65. The article demonstrates the practical application of the model by estimating the effective Young's modulus and the relative length of the fatigue crack initiation stage. Tensile plastic strains at critical sites exhibit a delocalization from around micropores followed by relocalization into thinning interpore walls with increasing microporosity, resulting in the highest fracture strain predicted for microporosities between 0.2 and 0.3. These strains enable the estimation of the length of the fatigue crack initiation stage, which proves to be very short for all microporosities. This emphasizes the crucial role of the crack growth stage in scaffold fatigue life and confirms the potential for additional experiments on scaffolds with microporosities exceeding 0.15 to enhance their fatigue resistance.

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Titanium-Based alloys and composites for orthopedic implants Applications: A comprehensive review

Cited by 51 publications

References 503 publications

Advancements in nanomaterials for nanosensors: a comprehensive review

Advancements in nanomaterials for nanosensors: a comprehensive review

Polydopamine-Coated Copper-Doped Co3O4 Nanosheets Rich in Oxygen Vacancy on Titanium and Multimodal Synergistic Antibacterial Study

Modeling Mechanical Properties of Titanium Scaffolds with Variable Microporosity

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