Titanium based bulk metallic glasses for biomedical applications

To purpose of this work is to determine the biocompatibility of the Zr58Co21Al9Ag12 alloy; vitreous ribbons of the Zr58Co21Al9Ag12 alloy were obtained by a chill block melt spinner. They were characterized by X-ray diffraction and transmission electron microscopy. Chemical homogeneity was examined by scanning electron microscopy. Similarly, thermal analysis was performed using differential scanning calorimetry. The nanoindentation test was performed with a Berkovich nanoindenter. Subsequently, the bioactivity was evaluated by chemical immersion in simulated body fluid. After immersion, it was characterized by XRD. A cell adhesion test was performed using mesenchymal stem cells from human dental pulp. Cell viability and proliferation were evaluated with a CCK-8 assay using human lymphocytes. The ribbons have crystalline phases close to 20%. The thermal parameters, Young’s modulus, and hardness were obtained. After the immersion test, Ca and P were identified. Ion release does not exceed critical levels for human cells. The alloy has a higher concentration of adhered cells compared to Ti6Al4V. The alloy remains bio-inert with respect to apatite formation; however, it exhibits excellent cell viability, proliferation, and adhesion behavior.

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Titanium based bulk metallic glasses for biomedical applications

Cited by 2 publications

References 41 publications

Machine learning-assisted design of biomedical high entropy alloys with low elastic modulus for orthopedic implants

Machine learning-assisted design of biomedical high entropy alloys with low elastic modulus for orthopedic implants

Influence of the Glassy Fraction Surface of a ZrCoAlAg Ribbon Alloy on the Bioactive Response to Simulated Body Fluid and Its Effect on Cell Viability

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