Titanium Biomimetically Coated With Hydroxyapatite, Silver Nitrate and Polycaprolactone, for Use In Biomaterials (Biomedicine)

Abstract

Titanium is used in orthopedic and orthodontic implants because it has good corrosion resistance and excellent biocompatibility. Thus, studies seek to obtain a coating to improve the adhesion between the bone and the implant, by modifying the metal's surface. The objective of this work was to biomimetically coat C.P. Ti with hydroxyapatite doped with silver nitrate, a component with antimicrobial properties, coating the metallic-ceramic composite with a polycaprolactone polymer film, which is known by generate improved implant-tissue interaction, and reducing postoperative complications from bacterial infections. The characterization of the material demonstrated the existence of the coating overall surface of the metallic substrate. The results obtained from the bacterial culture tests with Staphylococcus aureus showed that nitrate was effective in reducing the amount of live bacteria present in the supernatant, as well as those adhered to the surface of the material. In addition, the polymeric coating did not prevent the release of the bactericidal agent, not interfering in the effect there.

Key Properties of a Bioactive Ag-SiO2/TiO2 Coating on NiTi Shape Memory Alloy as Necessary at the Development of a New Class of Biomedical Materials

“…This might have favored the overgrowing of Gram-negative E. coli , which is the first phase of biofilm formation, and is known due to its motility [ 85 ]. As for the lack of the S. aureus biofilm formation in our study, a similar effect was previously observed for a titanium substrate [ 86 ]. This effect might be correlated with the hydrophilic character of the HAp coatings (estimated to be between 65° and 75°) and the surface roughness (close to 100 nm and lower), which limited or even inhibited the bacterial growth [ 64 , 82 ].…”

“…The XPS data revealed that the surface of the coat-forming material was composed of nonstoichiometric silica and hydroxyl groups that were anchored to the surface of the silica, which was probably negatively charged as well as the oxidized and metallic silver that limited the bacteria from coming into contact with the coating [ 62 ]. Similar results were also obtained for the coatings that had been prepared as a combination of silver-hydroxyapatite [ 87 ], silver-hydroxyapatite polymer coatings [ 86 ], or β-TCP + Ag-SiO 2 [ 44 ].…”

Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing

“…This proves that not only the ionic constitution, but also the manufacturing method of the metal alloys, are directly related to the interaction of the implant with the recipient tissue. Other studies support this information because they find an absence of immunological reactions and, in the case of titanium, it is due to the dense and well-adhered oxide layer that is formed in contact with different environments, such as air or water [29,35,[69][70][71][72]. Other researchers claim that the stable and protective oxide layer helps to connect the extracellular matrix to the implant surface [73,74].…”

“…The immediate outcome was successful, and the implant fitted precisely onto the large cranial defect. Therefore, the use of AM promotes reductions and cost savings for health systems and a better quality of life for a large number of patients [29,30].…”

Avaliação da biofuncionalidade de adição de prata em superfície anodizada de aço AISI 316L

“…Após a análise e discussão dos resultados da caracterização das superfícies anodizadas, foi selecionada a metodologia que apresentou resultado mais promissor para o processo de incorporação de prata na superfície. A incorporação de prata foi realizada em metodologia adaptada de Ferreira et al (2019) que consiste na agitação ultrassônica da amostra em solução de 5 mM de nitrato de prata por 1 hora em intervalos de 15 minutos para resfriamento da solução. Após a amostra foi seca por 48 horas em temperatura ambiente.…”