Titanium Carbide MXenes Mediated <i>In Situ</i> Reduction Allows Label-Free and Visualized Nanoplasmonic Sensing of Silver Ions

Wang, Yan; Wang, Song; Dong, Ningning; Kang, Wenyuan; Li, Kun; Nie, Zhou

doi:10.1021/acs.analchem.0c00164

Cited by 74 publications

(41 citation statements)

References 62 publications

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“…As a potential point-of-care detection technique, paper-based bioassays and analytical devices have several attractive advantages, such as low reagent consumption, easy operation, and low cost. , Recently, the smartphone has been widely adopted as a portable analysis device in biosensing because the technological advances in its built-in cameras enable the sensing of light and color changes with high sensitivity. , Therefore, we sought to convert the proposed method into a paper-based assay using a smartphone as the detection device (Figure A). First, we tested whether the SNAs can be well immobilized on papers and retain their reactivities toward transcribed RNAs.…”

Section: Resultsmentioning

confidence: 99%

Modular Combination of Proteolysis-Responsive Transcription and Spherical Nucleic Acids for Smartphone-Based Colorimetric Detection of Protease Biomarkers

Liu

Chen

et al. 2021

Anal. Chem.

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Sensitive and facile detection of biomarkers is essential for early diagnosis and treatment of diseases. To this end, we here proposed a colorimetric protease assay by the modular combination of proteolysis-responsive transcription and spherical nucleic acids (SNAs). In this assay, target protease-mediated proteolysis triggers the synthesis of RNAs by in vitro transcription, which subsequently results in the aggregation of SNAs with remarkable redshifts in the wavelength of surface plasmon resonance-related absorption. As a proof of concept, this assay achieved the sensitive and specific detection of matrix metalloprotease-2 (MMP-2) with a limit of detection of 3.3 pM. Moreover, the applicability of this colorimetric assay can be expanded to other protease biomarkers (e.g., thrombin and hepatitis C virus NS3/4A) by tuning the target-responsive RNA polymerase module. Furthermore, by the immobilization of SNAs on a glass fiber membrane, a test strip that enables the portable detection of target protease with a smartphone was developed. With the use of a mobile application to capture and process the colorimetric signals, this portable detection system allowed for sensitive evaluation of MMP-2 levels in biological and clinical specimens, highlighting its potential in point-of-care diagnosis of diseases.

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Section: Resultsmentioning

confidence: 99%

Modular Combination of Proteolysis-Responsive Transcription and Spherical Nucleic Acids for Smartphone-Based Colorimetric Detection of Protease Biomarkers

Liu

Chen

et al. 2021

Anal. Chem.

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“…In addition to the aforementioned PL measurement, light measurement can be used as the basis for various strategies, e.g., nanoplasmonic colorimetric sensing. [53] The properties of MXenes are beneficial for electrical-and optical-type chemical sensors. In particular, the low noise response of MXenes and high adsorption energy of gas molecules on the MXene surface, which are attributed to the high conductivity and surface functional group in MXene, contribute significantly to the high gas-sensing performance of chemical sensors.…”

Section: Photoluminescence-type Sensorsmentioning

confidence: 99%

Sensing with MXenes: Progress and Prospects

et al. 2021

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conventional technology is gradually reaching its limits in terms of further enhancement of sensor performance. Hence, tremendous efforts have been taken to explore the applicability of MXenes in various sensor technologies, including chemical, biological, mechanical, and optical sensors. The large specific surface area, high electrical conductivity, [1,2] and water dispersibility of MXenes, among their various excellent properties, constitute essential characteristics of a sensor material. Particularly, the 2D structure of MXene, which is conducive to functionalization using various terminal groups, provides a large number of active surface sites. These sites can serve as a highly responsive sensory platform for various external stimuli. Furthermore, the high electrical conductivity of MXenes is desirable for achieving low noise in sensory responses. Therefore, these characteristics demonstrate MXenes as a highly promising alternative sensor material for achieving high sensitivity, exceptionally low limit of detection (LOD), and minimum detectable amount of analytes in various sensor applications. Finally, the water dispersibility of MXenes facilitates environment-friendly fabrication and modification treatments; thus, they are further advantageous in processing.Because the fundamental properties of MXenes satisfy the requirements for an alternative sensor material, MXenebased sensor technology has been rapidly evolving over the last few years. The field of MXene-based sensors is facing conventional challenging problems as hurdles to commercialization: achieving reliably high performance, high stability, multifunctionality, and realizing homogeneous and reproducible scale-up processing (Figure 1a) of MXene-based sensors. Several recent studies on MXene-based sensors were aimed at establishing various structural and electrical approaches to utilize the excellent properties of MXene, thus boosting the sensor performance. For example, the macrostructuring of MXenes can significantly increase the sensitivity and lower the LOD of the resultant fabricated sensor. [3,4] Furthermore, the functionalization of MXene surfaces can impart useful properties of the secondary component to the MXene-based sensor to obtain higher performance than that of pristine MXenebased sensors. [5] These approaches have been highly effective and reliable, and thus significantly accelerated the progress of MXene-based sensor research. Figure 1b shows the network of co-occurring keywords in 2375 MXene-based research papers published since the discovery of MXenes in 2011. In an attempt to introduce new low-cost, high-performance, and Various fields of study consider MXene a revolutionary 2D material. Particularly in the field of sensors, the metal-like high electrical conductivity and large surface area of MXenes are desirable characteristics as an alternative sensor material that can transcend the boundaries of existing sensor technology. This critical review provides a comprehensive overview of recent advances in MXene-based sensor technology...

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“…proposed the label-free nanoplasmatic colorimetric detection of Ag + based on polyacrylic acid (PAA)-modified Ti 3 C 2 [85]. The PAA-Ti 3 C 2 exhibited better stability in aqueous solution.…”

Section: Mxenementioning

confidence: 99%

Two-Dimensional Material-Based Colorimetric Biosensors: A Review

2021

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Two-dimensional (2D) materials such as graphene, graphene oxide, transition metal oxide, MXene and others have shown high potential for the design and fabrication of various sensors and biosensors due to their 2D layered structure and unique properties. Compared to traditional fluorescent, electrochemical, and electrical biosensors, colorimetric biosensors exhibit several advantages including naked-eye determination, low cost, quick response, and easy fabrication. In this review, we present recent advances in the design, fabrication, and applications of 2D material-based high-performance colorimetric biosensors. Potential colorimetric sensing mechanisms and optimal material selection as well as sensor fabrication are introduced in brief. In addition, colorimetric biosensors based on different 2D materials such as graphene, transition metal dichalcogenide/oxide, MXenes, metal–organic frameworks, and metal nanoplates for the sensitive detection of DNA, proteins, viruses, small molecules, metallic ions, and others are presented and discussed in detail. This work will be helpful for readers to understand the knowledge of 2D material modification, nanozymes, and the synthesis of hybrid materials; meanwhile, it could be valuable to promote the design, fabrication, and applications of 2D material-based sensors and biosensors in quick bioanalysis and disease diagnostics.

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Titanium Carbide MXenes Mediated In Situ Reduction Allows Label-Free and Visualized Nanoplasmonic Sensing of Silver Ions

Cited by 74 publications

References 62 publications

Modular Combination of Proteolysis-Responsive Transcription and Spherical Nucleic Acids for Smartphone-Based Colorimetric Detection of Protease Biomarkers

Modular Combination of Proteolysis-Responsive Transcription and Spherical Nucleic Acids for Smartphone-Based Colorimetric Detection of Protease Biomarkers

Sensing with MXenes: Progress and Prospects

Two-Dimensional Material-Based Colorimetric Biosensors: A Review

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