Titanium, chromium and cobalt ions modulate the release of bone-associated cytokines by human monocytes/macrophages in vitro

Wang, James; Wicklund, Barbara H.; Gustilo, Ramon B.; Tsukayama, Dean T.

doi:10.1016/0142-9612(96)00072-5

Cited by 196 publications

(112 citation statements)

References 39 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…Metal ions also have an effect on macrophage activation, as shown for example in an in vitro study in which cells were exposed to titanium, chromium and cobalt (Wang et al 1996). The results showed different patterns of IL-1ß and TNF-α expression, but an inhibited release of transforming growth factor-ß1 (TGF-ß1) irrespective of the metal used.…”

Section: Mechanisms Of Cell Activation In Particle Diseasementioning

confidence: 97%

Aseptic loosening, not only a question of wear: A review of different theories

et al. 2006

View full text Add to dashboard Cite

Section: Mechanisms Of Cell Activation In Particle Diseasementioning

confidence: 97%

Aseptic loosening, not only a question of wear: A review of different theories

et al. 2006

View full text Add to dashboard Cite

“…Cellular response to the debris is the primary cause that limits the longevity of such implants [1][2][3][4][5][6][7][8][9] . Various cell lineages phagocytose/endocytose such non-biodegradable particulates resulting in the release of chemical entities, which has been hypothesized as one of the fundamental events that occur when wear-debris come in contact with surrounding cells [10][11][12][13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Phagocytosis of Simulated Nano-wear Debris by Osteoblasts

Musib¹

2012

View full text Add to dashboard Cite

In this study I have used well characterized simulated wear-nano-particles of ultra-high molecular weight polyethylene (UHMWPE) of known size and shape to study particulate phagocytosis by MG63 osteoblast-like cells. The particles were treated to decrease their propensity to form aggregates in aqueous suspension and scanning electron microscopy (SEM) was performed to image them as individual particles on 0.01 µm pore size polycarbonate filter membranes. These images were further subjected to morphometric analysis of the particles using ASTM F1877 descriptors [equivalent circle diameter (ECD in μm), aspect ratio (AR), elongation (E), roundness (R), and formfactor (FF)]. The mean (±SD) ECD of the particles were 0.056±0.03 µm. They were subsequently introduced to confluent MG63 cells at particle:cell ratio of 100:1 and incubated for 24 h. Transmission electron micrography (TEM) showed the nanoparticles inside the cytosol. No time dependent response was observed beyond 24 h. The nanoparticles seemed to re-agglomerate once inside the cell. The damage to the cells was evident from the compromised cell membrane. This study will help further our knowledge of the wear-mediated osteolytic process.

show abstract

“…In instances of extreme debris generation in titanium implants, the periprosthetic tissue had reached levels of 2.5 dry wt.% of titanium particles with random distribution of particle size and shape [6]. Resetrrcli 22 (2004) [229][230][231][232][233][234][235][236] and from wear of the high molecular weight polyethylene acetabular cup [5,10,14,29,31,36] and metal femoral head during articulation of the prosthesis [6,9,11,12,[15][16][17][18][19][20][21]23,25,27,30,[32][33][34][35]. However, in radiographs of well-fixed cementless implants, there are radiolucent areas adjacent to the distal end of the implant stem, isolated from the femoral head and acetabular cup by a proximal area of well-integrated implant-bone interface [6,22].…”

Section: Introductionmentioning

confidence: 99%

New insight into the mechanism of hip prosthesis loosening: Effect of titanium debris size on osteoblast function

O’Connor

Choil

Kwon

et al. 2004

Journal Orthopaedic Research

View full text Add to dashboard Cite

The incidence of rheumatoid arthritis and osteoarthritis is on the rise due to our expanding elderly population. Total joint arthroplasty is the most successful, prevalent treatment modality for these and other degenerative hip conditions. Despite the wide array of prosthetic devices commercially available, hip prostheses share a common problem with a gradual and then accelerating loss of bone tissue and bone-implant interface integrity, followed by implant instability and loosening. Implant failure is largely the result of inevitable wear of the device and generation of wear debris. To provide information for the development of improved prosthetic wear characteristics, we examined the effects of size-separated titanium particles on bone forming cell populations. We demonstrate unequivocally that particle size is a critical factor in the function, proliferation, and viability of bone-forming osteoblasts in vitro. In addition, we have elucidated the time-dependent distribution of the phagocytosed particles within the osteoblast, indicating an accumulation of particles in the perinuclear area of the affected cells. The report finds that particle size is a critical factor in changes in the bone formation-related functions of osteoblasts exposed to simulate wear debris, and that 1.5-4 pm titanium particles have the greatest effect on osteoblast proliferation and viability in vitro. The size of titanium particles generated through wear of a prosthetic device may be an important consideration in the development of superior implant technology.

show abstract

Titanium, chromium and cobalt ions modulate the release of bone-associated cytokines by human monocytes/macrophages in vitro

Cited by 196 publications

References 39 publications

Aseptic loosening, not only a question of wear: A review of different theories

Aseptic loosening, not only a question of wear: A review of different theories

Phagocytosis of Simulated Nano-wear Debris by Osteoblasts

New insight into the mechanism of hip prosthesis loosening: Effect of titanium debris size on osteoblast function

Contact Info

Product

Resources

About