Titanium complexes supported by imidazo[1,5-a]pyridine-containing pyrrolyl ligand as catalysts for hydroamination and polymerization reactions, and as an antitumor reagent

Abstract

The syntheses, structures, catalytic properties and antitumor activities of three titanium complexes supported by an imidazo[1,5-a]pyridine-containing pyrrolyl ligand are reported.

A Concise Review of Multicomponent Reactions Using Novel Heterogeneous Catalysts under Microwave Irradiation

“…The pyridines have a wide range of applications, frequently being used in fluorescence sensors, laser dyes and molecular switches [97], confocal microscopy [98], medical applications [99,100], anti-inflammatory [101], DNA and RNA structural constituents [102][103][104], antioxidants [105], antimicrobial [106,107], fungicidal [108] to treat hepatitis B [109] and C [110], arterial thrombosis [111], Alzheimer's [112], tumours [113], and kidney diseases [114].…”

Titanium complexes bearing 2,6‐bis(o‐hydroxyalkyl)pyridine ligands in vitro cytotoxicity against triple‐negative breast‐cancer cells

“…[22] The X-ray structure of H L Me -TiOPr 2 (CCDC 2005808, Figure 4) revealed the trigonal bipyramidal geometry (τ = 1.00) [24] with two terminal isopropoxides. The axial angle of N(3) Ti( 1) O(4) was 178.89 (8)…”

“…Therefore, nonplatinum metal complexes have been developed to replace platinum-based complexes. Among these nonplatinum complexes, Ti complexes [3][4][5][6][7][8][9][10][11][12][13][14][15] exhibit considerable antitumor activity as shown in Figure 1.…”

Use of pyrazoles as ligands greatly enhances the catalytic activity of titanium iso-propoxide for the ring-opening polymerization of l-lactide: a cooperation effect

“…Because of the non-cytotoxic property and strong Lewis acidity of titanium, Ti complexes 22,23,[30][31][32][33] are commonly used catalysts in LA ROP. Numerous Ti complexes bearing various ligands such as calix [4] arene, 33,34 Schiff base, [35][36][37][38][39] salen, [40][41][42] salan, [43][44][45][46] phenolate, [47][48][49][50] aminophenolate, 51,52 benzotriazole phenolate, [53][54][55] phosphinophenolate, 56 thiophenolate, 57,58 bis-phenolate-N-heterocyclic carbene, 45 pyridonate, 59,60 and pyrrolide 61 have been reported to exhibit considerable catalytic activity or controllability, which is contributed by ligands. However, for most studies, focusing on materials is inconvenient, because the synthesis and purication of Ti catalysts are time-consuming processes.…”