Titanium dioxide nanotubes as drug carriers for infection control and osteogenesis of bone implants

Wang, Kun; Jin, Haoyu; Song, Qing; Huo, Jianhua; Zhang, Jing; Li, Peng

doi:10.1007/s13346-021-00980-z

Cited by 41 publications

(24 citation statements)

References 153 publications

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“…Drug molecules with antibacterial and osteogenic properties were loaded into TNT using various techniques, including physical adsorption, electrophoretic deposition, and magnetron sputtering. Changing the surface morphology of TNT can prolong the elution time of the drug and extend the duration of action of functional drug molecules against infection and contribute to bone regeneration ( Wang K. et al, 2021 ). Jiao et al prepared implant coatings containing BMP2 and GelMA/PMAA-Cl on TNT.…”

Section: Antibacterial-osteogenic Modifications Of Dental Implant Sur...mentioning

confidence: 99%

Advances and Prospects in Antibacterial-Osteogenic Multifunctional Dental Implant Surface

Wang

Cai

et al. 2022

Front. Bioeng. Biotechnol.

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In recent years, dental implantation has become the preferred protocol for restoring dentition defects. Being the direct contact between implant and bone interface, osseointegration is the basis for implant exerting physiological functions. Nevertheless, biological complications such as insufficient bone volume, poor osseointegration, and postoperative infection can lead to implant failure. Emerging antibacterial-osteogenic multifunctional implant surfaces were designed to make up for these shortcomings both during the stage of forming osseointegration and in the long term of supporting the superstructure. In this mini-review, we summarized the recent antibacterial-osteogenic modifications of the dental implant surface. The effects of these modifications on biological performance like soft tissue integration, bone osteogenesis, and immune response were discussed. In addition, the clinical findings and prospects of emerging antibacterial-osteogenic implant materials were also discussed.

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Section: Antibacterial-osteogenic Modifications Of Dental Implant Sur...mentioning

confidence: 99%

Advances and Prospects in Antibacterial-Osteogenic Multifunctional Dental Implant Surface

Wang

Cai

et al. 2022

Front. Bioeng. Biotechnol.

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“…Wang et al describe the creation of an array of titanium dioxide nanotubes (TNTs) on the surface of titanium implants using anodic oxidation. These are proposed to be beneficial to bone ingrowth but could also be used as drug carriers to confer anti-infective properties to the material [116].…”

Section: Local Carriers and Coatingsmentioning

confidence: 99%

Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants

Rodríguez-Merchán

Davidson

Liddle

2021

IJMS

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Biofilm-related implant infections (BRII) are a disastrous complication of both elective and trauma orthopaedic surgery and occur when an implant becomes colonised by bacteria. The definitive treatment to eradicate the infections once a biofilm has established is surgical excision of the implant and thorough local debridement, but this carries a significant socioeconomic cost, the outcomes for the patient are often poor, and there is a significant risk of recurrence. Due to the large volumes of surgical procedures performed annually involving medical device implantation, both in orthopaedic surgery and healthcare in general, and with the incidence of implant-related infection being as high as 5%, interventions to prevent and treat BRII are a major focus of research. As such, innovation is progressing at a very fast pace; the aim of this study is to review the latest interventions for the prevention and treatment of BRII, with a particular focus on implant-related approaches.

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“…However, during treatment, patients are prone to serious healthcare-associated infections (HAIs) such as central line-associated bloodstream infections, catheter-associated urinary tract infections, ventilator-associated pneumonia, peri-implants, surgical site infections, etc. 1,2 HAIs result in substantial morbidity and mortality and potentially bring about a large increase in the cost of caring for patients, and HAIs are often exacerbated by surfaces that support bacterial attachment and subsequent biofilm formation. 3−6 Biofilms are surfaceattached bacterial communities embedded in a hydrated extracellular polymeric substance (EPS) primarily composed of exopolysaccharides, proteins, and enzymes.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In modern healthcare, invasive devices are extensively used in clinical practice. However, during treatment, patients are prone to serious healthcare-associated infections (HAIs) such as central line-associated bloodstream infections, catheter-associated urinary tract infections, ventilator-associated pneumonia, peri-implants, surgical site infections, etc. , HAIs result in substantial morbidity and mortality and potentially bring about a large increase in the cost of caring for patients, and HAIs are often exacerbated by surfaces that support bacterial attachment and subsequent biofilm formation. − Biofilms are surface-attached bacterial communities embedded in a hydrated extracellular polymeric substance (EPS) primarily composed of exopolysaccharides, proteins, and enzymes. , The EPS works as a guardian barrier against drug infiltrations and cellular attacks by the host innate immune system . Biofilm-induced HAIs have become one of the most prevalent and serious complications due to the ease of biofilm formation and difficulty of biofilm removal on implanted devices .…”

Section: Introductionmentioning

confidence: 99%

Photoactivatable Nitric Oxide-Releasing Gold Nanocages for Enhanced Hyperthermia Treatment of Biofilm-Associated Infections

Tang

Wang

Feng

et al. 2021

ACS Appl. Mater. Interfaces

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With the increasing clinical use of invasive medical devices, various healthcare-associated infections (HAIs) caused by bacterial biofilm colonization of biomedical devices have posed serious threats to patients. The formation of biofilms makes it much more difficult and costly to treat infections. Here, we report a nitric oxide (NO)-releasing gold nanocage (AuNC@NO) that is stimulated by near-infrared (NIR) irradiation to deliver NO and generate hyperthermia for biofilm elimination. AuNC@NO was prepared by immobilizing a temperature-responsive NO donor onto gold nanocages (AuNCs) through thiol–gold interactions. AuNC@NO possesses stable and excellent photothermal conversion efficiency, as well as the characteristics of slow NO release at physiological temperature and on-demand quick NO release under NIR irradiation. Based on these features, AuNC@NO exhibits enhanced in vitro bactericidal and antibiofilm efficacy compared with AuNCs, which could achieve 4 orders of magnitude bacterial reduction and 85.4% biofilm elimination under NIR irradiation. In addition, we constructed an implant biofilm infection model and a subcutaneous biofilm infection model to evaluate the anti-infective effect of AuNC@NO. The in vivo results indicated that after 5 min of 0.5 W cm–2 NIR irradiation, NO release from AuNC@NO was significantly accelerated, which induced the dispersal of methicillin-resistant Staphylococcus aureus (MRSA) biofilms and synergized with photothermal therapy (PTT) to kill planktonic MRSA that had lost its biofilm protection. Meanwhile, the surrounding tissues showed little damage because of controlled photothermal temperature and toxicity. In view of the above-mentioned results, the AuNC@NO nanocomposite developed in this work reveals potential application prospects as a useful antibiofilm agent in the field of biofilm-associated infection treatment.

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Titanium dioxide nanotubes as drug carriers for infection control and osteogenesis of bone implants

Cited by 41 publications

References 153 publications

Advances and Prospects in Antibacterial-Osteogenic Multifunctional Dental Implant Surface

Advances and Prospects in Antibacterial-Osteogenic Multifunctional Dental Implant Surface

Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants

Photoactivatable Nitric Oxide-Releasing Gold Nanocages for Enhanced Hyperthermia Treatment of Biofilm-Associated Infections

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