Titanium Fiber Plates for Bone Tissue Repair

Takizawa, Takashi; Nakayama, Noboru; Haniu, Hisao; Aoki, Katsumi; Okamoto, Masato; Nomura, Hiroki; Sobajima, Atsushi; Yoshida, Kazuhide; Kamanaka, Takayuki; Ajima, Kumiko; Oishi, Ayumu; Kuroda, Chika; Ishida, Haruka; Okano, Satomi; Kobayashi, Shinsuke; Kato, Hiroyuki

doi:10.1002/adma.201703608

Cited by 103 publications

(52 citation statements)

References 53 publications

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“…By contrast, our transparent biofilms have high compressive resistance ( E r ≈ 18.842 GPa, H ≈ 0.217 GPa, owing to their compacted structure), superior to those of most plastics, and such high E r has endowed the biofilms with a stiffness comparable to bone ( E r ≈ 15–30 GPa), favorable for keeping the adequate cross‐plane breathability when on‐skin use.…”

Section: Resultsmentioning

confidence: 89%

Breathable Nanowood Biofilms as Guiding Layer for Green On‐Skin Electronics

Zhou

Wang

Huang

et al. 2019

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thermoelectric [3,4] and moisture-inducedelectric [5] effects also has gained great attention (skin and on-skin electronics (On-skinE) themselves are energy storehouse). However, several challenges are to be faced, "thin-film" On-skinE I) cannot install "bulky" heatsinks [6] or sweat transport channels, but the output power of the thermoelectric generator and moistureinduced-electric generator depends on the temperature difference (∆T) across generator [4] and the ambient humidity (AH), [5] respectively; II) also lack a routing and accumulation of sweat for biosensing technologies, [7,8] and lack a targeted delivery of drugs for precise feedback transdermal therapy technologies; [9,10] and III) need insulate between the heatgenerating unit and heat-sensitive unit.In these regards, a "routing and accumulation" of heat and sweat can "concurrently" enhance the ∆T/AH-dependent output power, enable a reliable sweatbased biosensing, and prove the ability of targeted delivery of saline-soluble drugs for precise feedback transdermal therapy. Therefore, it is in great demand for developing strong-guiding films, which can help insulate between units and guide the heat and sweat to another in-plane direction.Besides, breathability [3] and stretchability [11] are essential for the on-skin use of electronics with long-term comfort. Several strategies have been proposed to realize the "stretchability" and the strategy placing rigid electronic units on the Thin-film electronics are urged to be directly laminated onto human skin for reliable, sensitive biosensing together with feedback transdermal therapy, their self-power supply using the thermoelectric and moisture-induced-electric effects also has gained great attention (skin and on-skin electronics (On-skinE) themselves are energy storehouses). However, "thin-film" On-skinE 1) cannot install "bulky" heatsinks or sweat transport channels, but the output power of thermoelectric generator and moisture-induced-electric generator relies on the temperature difference (∆T ) across generator and the ambient humidity (AH), respectively; 2) lack a routing and accumulation of sweat for biosensing, lack targeted delivery of drugs for precise transdermal therapy; and 3) need insulation between the heat-generating unit and heat-sensitive unit. Here, two breathable nanowood biofilms are demonstrated, which can help insulate between units and guide the heat and sweat to another in-plane direction. The transparent biofilms achieve record-high transport // /transport ⊥ (//: along cellulose nanofiber alignment direction, ⊥: perpendicular direction) of heat (925%) and sweat (338%), winning applications emphasizing on ∆T/AH-dependent output power and "reliable" biosensing. The porous biofilms are competent in applications where "sensitive" biosensing (transporting // sweat up to 11.25 mm s −1 at the 1st second), "insulating" between units, and "targeted" delivery of saline-soluble drugs are of uppermost priority.

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Section: Resultsmentioning

confidence: 89%

Breathable Nanowood Biofilms as Guiding Layer for Green On‐Skin Electronics

Zhou

Wang

Huang

et al. 2019

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“…Materials can be broadly divided into biodegradable and nonbiodegradable materials. Collagen [18], poly-L-lactic acid (PLLA) [19], resorbable bioactive glass (BG) [20], and bioresorbable ceramics (BCs) including β-tricalcium phosphate (TCP) [21] are used as biodegradable materials, while metal (e.g., titanium) [22,23], carbon [24], and polyetheretherketone (PEEK) [25] are used as nonbiodegradable materials. Advantages of biodegradable scaffolds lie in the osseous replacement that occurs at the same time as bone regeneration, providing a more biomimetic regeneration with less risk of infections and foreign body reactions; however, when used for filling large bone defects, residual bone defects may remain.…”

Section: Bone Regenerative Medicinementioning

confidence: 99%

Applications of Carbon Nanotubes in Bone Regenerative Medicine

Tanaka¹,

Aoki

Haniu

et al. 2020

Nanomaterials

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Scaffolds are essential for bone regeneration due to their ability to maintain a sustained release of growth factors and to provide a place where cells that form new bone can enter and proliferate. In recent years, scaffolds made of various materials have been developed and evaluated. Functionally effective scaffolds require excellent cell affinity, chemical properties, mechanical properties, and safety. Carbon nanotubes (CNTs) are fibrous nanoparticles with a nano-size diameter and have excellent strength and chemical stability. In the industrial field, they are used as fillers to improve the performance of materials. Because of their excellent physicochemical properties, CNTs are studied for their promising clinical applications as biomaterials. In this review article, we focused on the results of our research on CNT scaffolds for bone regeneration, introduced the promising properties of scaffolds for bone regeneration, and described the potential of CNT scaffolds.

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“…钛金属质轻, 具有优良的机械性能和弹性模量和较高的生物相容性, 其密度接近人体骨, 已成骨科人工骨、人工关节、骨钉等手术的医用材料 [101,102] . 然而, 钛金属自身具有较高的生物惰性, 容易被体内的纤维组织包覆, 从而导致材料与骨组织分离, 造成移植失败.…”

Section: 钛及钛合金纳米复合材料unclassified