Titanium oxide– and oxynitride–coated nitinol: Effects of surface structure and composition on interactions with endothelial cells

Суровцева, М. А.; Poveschenko, Olga V.; Kuzmin, Oleg S.; Kim, I. I.; Кожухов, А. С.; Бондаренко, Н. А.; Chepeleva, Elena V.; Kolodin, A. N.; Лыков, А. П.; Shcheglov, D. A.; Пичугин, В. Ф.; Zhuravleva, I. Yu.

doi:10.1016/j.apsusc.2021.152059

Cited by 16 publications

(13 citation statements)

References 38 publications

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Section: Introductionmentioning

confidence: 99%

“…In the last decade, several studies have addressed the interaction between TiO x N y -coated surfaces and various types of cells: smooth muscle cells (SMC) [ 18 ], mesenchymal stem cells (MSC) [ 19 ], and endothelial cells (EC) [ 20 ]. It has been shown [ 19 , 20 ] that the cytocompatibility of a surface coated with N-doped TiO 2 depends on the nitrogen content of the coating. The nanoroughness, hydrophilicity, crystallinity, and composition of the surface can be changed by selecting the gas composition of the reaction mixture, bias voltage, and the magnetron’s sputtering time [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown [ 19 , 20 ] that the cytocompatibility of a surface coated with N-doped TiO 2 depends on the nitrogen content of the coating. The nanoroughness, hydrophilicity, crystallinity, and composition of the surface can be changed by selecting the gas composition of the reaction mixture, bias voltage, and the magnetron’s sputtering time [ 20 , 21 ]. These surface parameters influence the production of nitric oxide (NO) by endothelial cells and the cells’ adhesion, spreading, and viability on coated substrates.…”

Section: Introductionmentioning

confidence: 99%

“…These surface parameters influence the production of nitric oxide (NO) by endothelial cells and the cells’ adhesion, spreading, and viability on coated substrates. It is known that different cell lines react differently to an increase in the nitrogen content in the coating, which, for example, inhibits the proliferation and differentiation of MSCs [ 19 ], but improves the viability and NO production of endothelial cells [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…The best way to do this is unclear. We previously faced this problem when studying six coatings of a nitinol substrate by using four biological and four physical tests [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Integral Algorithms to Evaluate TiO2 and N-TiO2 Thin Films’ Cytocompatibility

Zhuravleva

Суровцева

Alshevskaya

et al. 2022

IJMS

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Titanium oxide (TiO2) and oxynitride (N-TiO2) coatings can increase nitinol stents’ cytocompatibility with endothelial cells. Methods of TiO2 and N-TiO2 sputtering and cytocompatibility assessments vary significantly among different research groups, making it difficult to compare results. The aim of this work was to develop an integral cytocompatibility index (ICI) and a decision tree algorithm (DTA) using the “EA.hy926 cell/TiO2 or N-TiO2 coating” model and to determine the optimal cytocompatible coating. Magnetron sputtering was performed in a reaction gas medium with various N2:O2 ratios and bias voltages. The samples’ morphology was studied by scanning electron microscopy (SEM) and Raman spectroscopy. The cytocompatibility of the coatings was evaluated in terms of their cytotoxicity, adhesion, viability, and NO production. The ICI and DTA were developed to assess the cytocompatibility of the samples. Both algorithms demonstrated the best cytocompatibility for the sample sputtered at Ubias = 0 V and a gas ratio of N2:O2 = 2:1, in which the rutile phase dominated. The DTA provided more detailed information about the cytocompatibility, which depended on the sputtering mode, surface morphology, and crystalline phase. The proposed mathematical models relate the cytocompatibility and the studied physical characteristics.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The best way to do this is unclear. We previously faced this problem when studying six coatings of a nitinol substrate by using four biological and four physical tests [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Integral Algorithms to Evaluate TiO2 and N-TiO2 Thin Films’ Cytocompatibility

Zhuravleva

Суровцева

Alshevskaya

et al. 2022

IJMS

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Titanium Dioxide Covalently Immobilized Citric Acid (TiO₂‐CA) Nanohybrid Coating of Neurovascular Flow Diverter to Improve Antithrombogenic and Pro‐Endothelialization Properties

Qian

Zhang

Gao

et al. 2022

Adv Materials Inter

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FDs can also treat aneurysms that had been previously intractable or untreatable. The mechanics lie in FDs being able to alter the direction of blood flow in the aneurysm's parent vessel to reduce the blood flow velocity inside it to favor thrombosis and therefore accomplish embolization. [2] It also serves to boost reendothelialization, remodel the vascular wall, and exclude aneurysms from circulation eventually. [3] To date, numerous studies have confirmed the efficacy and safety of FDs. [4] Although FDs are still in their infancy, there have already been several products available on the market, namely Pipeline (Medtronic, USA), p48 and p64flow modulation devices (Phenox, Germany), FRED (MicroVention, USA), Derivo (Acandis, Germany), Silk (Balt Extrusion, France), and Surpass/Streamline (Stryker, USA), and there will be more. [4b] The FDs currently used, however, are not without problems. The biggest problem is that they will trigger plasma protein adhesion and activate coagulation cascade reactions once they are placed into the target blood vessel, which leads readily to thrombosis. [3] Thus, dual antiplatelet therapy (DAPT), such as aspirin and clopidogrel, is mandatory for patients to avoid

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Physico-chemical Evaluation of Antiatherosclerotic Coronary Stent Coatings Based on Poly(lactic acid) Doped with Functionalized Fe@C Nanoparticles

Goreninskii,

Konishchev,

Bolbasov

et al. 2023

BioNanoSci.

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Titanium oxide– and oxynitride–coated nitinol: Effects of surface structure and composition on interactions with endothelial cells

Cited by 16 publications

References 38 publications

Integral Algorithms to Evaluate TiO2 and N-TiO2 Thin Films’ Cytocompatibility

Integral Algorithms to Evaluate TiO2 and N-TiO2 Thin Films’ Cytocompatibility

Titanium Dioxide Covalently Immobilized Citric Acid (TiO₂‐CA) Nanohybrid Coating of Neurovascular Flow Diverter to Improve Antithrombogenic and Pro‐Endothelialization Properties

Physico-chemical Evaluation of Antiatherosclerotic Coronary Stent Coatings Based on Poly(lactic acid) Doped with Functionalized Fe@C Nanoparticles

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Titanium oxide– and oxynitride–coated nitinol: Effects of surface structure and composition on interactions with endothelial cells

Cited by 16 publications

References 38 publications

Integral Algorithms to Evaluate TiO2 and N-TiO2 Thin Films’ Cytocompatibility

Integral Algorithms to Evaluate TiO2 and N-TiO2 Thin Films’ Cytocompatibility

Titanium Dioxide Covalently Immobilized Citric Acid (TiO2‐CA) Nanohybrid Coating of Neurovascular Flow Diverter to Improve Antithrombogenic and Pro‐Endothelialization Properties

Physico-chemical Evaluation of Antiatherosclerotic Coronary Stent Coatings Based on Poly(lactic acid) Doped with Functionalized Fe@C Nanoparticles

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About

Titanium Dioxide Covalently Immobilized Citric Acid (TiO₂‐CA) Nanohybrid Coating of Neurovascular Flow Diverter to Improve Antithrombogenic and Pro‐Endothelialization Properties