Powder metallurgy (PM) of titanium is a potentially cost-effective alternative to conventional wrought titanium. This article examines both traditional and emerging technologies, including the production of powder, and the sintering, microstructure, and mechanical properties of PM Ti. The production methods of powder are classified into two categories: (1) powder that is produced as the product of extractive metallurgy processes, and (2) powder that is made from Ti sponge, ingot, mill products, or scrap. A new hydrogen-assisted magnesium reduction (HAMR) process is also discussed. The mechanical properties of Ti-6Al-4V produced using various PM processes are analyzed based on their dependence on unique microstructural features, oxygen content, porosity, and grain size. In particular, the fatigue properties of PM Ti-6Al-4V are examined as functions of microstructure. A hydrogen-enabled approach for microstructural engineering that can be used to produce PM Ti with wroughtlike microstructure and properties is also presented.