Titanocene-Mediated Intramolecular Radical Vinylations

Abstract

A new titanium-mediated domino intramolecular radical vinylation is described. It relies on the radical b-elimination of sulfoximyl and phosphinoyl radicals, and leads efficiently to exo-alkylidene pyrrolidines with one stereogenic center b to the nitrogen. The reaction of phosphine oxides has been shown to effectively follow a radical pathway.