Title clear cell renal carcinoma metastasis mimicking primary thyroid tumor

Kaliszewski, Krzysztof; Szkudlarek, Danuta; Kasperczak, Michał; Nowak, Łukasz

doi:10.20452/pamw.4425

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…Most scholars believe that the prognosis of TM is generally poor. The median survival time reported in previous literature is 8.8-34.0 months (15,21,22), and the five-year overall survival rate is 11%-58% (1,23,24). Factors associated with prognosis include the type of primary tumor (20) and the occurrence time, number, size, and location of the metastatic tumors (25).…”

Section: Prognosismentioning

confidence: 99%

Neuroendocrine neoplasm with metastasis to the thyroid: a case report and literature review

Lin

Teng

et al. 2023

Front. Oncol.

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Thyroid cancer can be divided into two types according to its cellular origin, i.e., malignant tumors originating from thyroid cells and cancers that metastasize to the thyroid from other sites, the latter of which are, clinically rare. This article reports the diagnosis and treatment of a rectal neuroendocrine neoplasm metastasis to the thyroid. No similar cases have been reported before. This case suggests that when evaluating thyroid tumors, clinicians should not only carefully identify the clinical features of the tumor but also pay special attention to the patient’s history of tumors, especially neuroendocrine neoplasms. For definite secondary thyroid malignancies, neck surgery is feasible if the thyroid is the only site of metastasis; otherwise, the subsequent diagnosis and treatment plan should be determined after a comprehensive evaluation of the primary tumor and patient’s general condition.

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Section: Prognosismentioning

confidence: 99%

Neuroendocrine neoplasm with metastasis to the thyroid: a case report and literature review

Lin

Teng

et al. 2023

Front. Oncol.

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“…CKs 7, 8, and 19 are negative. Clear cell renal cell carcinoma (CCRCC) may present as a thyroid nodule, while the primary renal tumor is silent [5,6]. Distinguishing this tumor from clear cell thyroid adenoma by routine staining is difficult.…”

Section: Figure 5 -Ihc Reactivity Of the Follicular Adenoma With Clear Cell Change The Clear Balloon-shaped Cells Show Positivity For Panmentioning

confidence: 99%

“…Other conditions with clear cell change comprise cases of ectopic parathyroid in the thyroid gland, dyshormonogenetic goiter, Hashimoto's thyroiditis, and nodular hyperplasia [4]. In addition, metastatic clear cell carcinoma principally from the kidney can manifest as a thyroid enlargement [5,6].…”

Section:  Introductionmentioning

confidence: 99%

Clear cell change in follicular adenoma of the thyroid. A diagnostic challenge

Val‐Bernal

Martino²

2020

Rom J Morphol Embryol

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Clear cells in thyroid neoplasms can take two main forms: balloon-shaped and signet-ring cells. Balloon-shaped cell change in follicular adenoma is rare. A review of the literature has revealed only 20 previously published cases. We report herein a new case in the right thyroid lobe of a 45-year-old man. The clinicopathological data of the 21 cases including our paper have revealed that the ages of the patients ranged from 22-70 years, with a mean of 41.6 years. There was a clear predominance in women (M:F, 1:6). The most frequent location was in either of both lobes (81.8%), rarely affecting the isthmus. One case was observed in an ectopic thyroid in the submandibular region. The size ranged from 0.7-5.5 cm (mean 2.9 cm). The type of surgical intervention where this data was reported it was lobectomy for 10 (55.5%) cases, thyroidectomy for six (33.3%) cases, and simple excision for two (11.1%) cases. In one patient, the lobectomy was accompanied by cervical lymph node dissection. No cases recurred or extended outside the thyroid. The main differential diagnoses include intrathyroidal clear cell tumor of parathyroid origin, clear cell carcinoma of follicular, oncocytic, papillary, medullary or undifferentiated (anaplastic) origin, paraganglioma, metastatic clear cell carcinoma, especially of renal origin, metastatic balloon cell melanoma, and clear large-cell lymphoma. A thyroid lesion showing clear cell change constitutes a diagnostic challenge in cytological and biopsy diagnosis. Careful observation of the routine techniques along with the aid of an adequate immunohistochemical panel is essential to reach a correct biopsy diagnosis.

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“…Secondary malignancies of thyroid gland (SMTG) are uncommon, with an incidence of 1.25%–24% in autopsy series, 2 and 1.4%–3% in all patients operated on for thyroid malignancies 3 . Secondary tumors most commonly involving the thyroid gland include tumors of the pharynx, larynx, esophagus, and mediastinum, and sources of distant metastatic tumors, include the kidney, lung, breast, and gastrointestinal tract 4–10 …”

Section: Introductionmentioning

confidence: 99%

“…3 Secondary tumors most commonly involving the thyroid gland include tumors of the pharynx, larynx, esophagus, and mediastinum, and sources of distant metastatic tumors, include the kidney, lung, breast, and gastrointestinal tract. [4][5][6][7][8][9][10] In rare cases, metastases in the thyroid may be the primary clinical manifestation of distant malignancy. Therefore, correct identification of these secondary tumors in samples from FNA of thyroid nodules is important to avoid unnecessary surgical resection in patients who have extensive metastases.…”

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confidence: 99%

Fine‐needle aspiration diagnosis of secondary malignant tumors of the thyroid gland: A single‐institution experience of 17 cases

Zhang,

Lei,

Chen

et al. 2024

Diagnostic Cytopathology

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BackgroundFine‐needle aspiration (FNA) is the most commonly used preoperative pathological diagnostic tool for thyroid tumors. Secondary malignant tumors of the thyroid gland account for less than 3% of all thyroid malignancies. The aim of this study was to investigate the types and cytopathological features of secondary thyroid tumors, evaluate diagnostic pitfalls in FNA.MethodsCases of secondary thyroid tumors diagnosed in the Department of Pathology of Shaanxi Provincial People's Hospital were collected, and their clinical data, cytologic features, immunohistochemical results, and histopathological diagnoses were summarized.ResultsThe study included 17 cases (8 males and 9 females) with a mean age of 60.4 ± 9.4 years (range, 45–83 years). Six cases had a known history of primary malignancy prior to FNA aspiration diagnosis. The most common organs of origin were the lungs (5 cases, 3 adenocarcinoma, and 2 small‐cell carcinoma) and esophagus (5 cases, 3 squamous‐cell carcinoma, 1 adenocarcinoma, and 1 small‐cell carcinoma). The next most common was squamous‐cell carcinoma of the larynx (3 cases), and gastric tumor (2 cases), including 1 lymphoma and 1 adenocarcinoma. Cell blocks and immunohistochemistry were performed in 12 of these cases. Comparison of the impact of positive history and IHC availability on the accuracy of pathologic diagnosis showed that both were statistically significant.ConclusionFNA is an effective means of diagnosing secondary malignancies of the thyroid, in which knowledge of the patient's history of malignancy is essential, and the use of cell blocks and immunohistochemistry helps to clarify the pathological diagnosis.

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Title clear cell renal carcinoma metastasis mimicking primary thyroid tumor

Cited by 4 publications

References 3 publications

Neuroendocrine neoplasm with metastasis to the thyroid: a case report and literature review

Neuroendocrine neoplasm with metastasis to the thyroid: a case report and literature review

Clear cell change in follicular adenoma of the thyroid. A diagnostic challenge

Fine‐needle aspiration diagnosis of secondary malignant tumors of the thyroid gland: A single‐institution experience of 17 cases

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