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Bamberger, Ph.; Matthes, A

doi:10.1159/000387986

Cited by 5 publications

(6 citation statements)

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“…The remaining autopsies were carried out at the Institute of Neuropathology of the Free University, Berlin (Prof. Dr. J. Cervos-Navarro) between 1971 and 1976. 2 The patient records were mostly available in their entirety. In most cases the relatives ofthe children, who had died, were catarnnestically questioned.…”

Section: Methodsmentioning

confidence: 99%

Morphological Aspects of Aetiology and the Course of Infantile Spasms (West-Syndrome)¹

1985

Neuropediatrics

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The present study using the results of the postmortem examination of twenty-four children, who had infantile spasms (West-Syndrome), gives a view of the aetiology and course of the West-Syndrome. According to the time of occurrence of the lesions three groups could be established: one group of six cases with only embryofetal lesions, one group of ten cases with combined embryofetal and peri/postnatal lesions and one group of eight cases with only peri/postnatal lesions. It is significant, that the time of onset of infantile spasms depends on time of manifestation of lesions. In the groups with combined embryofetal and peri/postnatal lesions the seizures were manifested at the same time as in the cases with isolated embryofetal lesions. Even in the group with combined lesions, microdysgenesis was interpreted as being embryofetal. These embryofetal lesions, as opposed to the peri/postnatal lesions thus appear to dominate and thereby to be pathoplastic. From this correlation two thirds of the cases of infantile spasms can be regarded as fetal epilepsies. The question is open if the infantile spasms which are manifested later on and develop mostly a Lennox-Syndrome indeed should be classified as a separate group together with the isolated peri/postnatal lesions.

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Section: Methodsmentioning

confidence: 99%

Morphological Aspects of Aetiology and the Course of Infantile Spasms (West-Syndrome)¹

1985

Neuropediatrics

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“…Assuming genetic relations between febrile convulsions and epilepsy is justified by the following studies: the risk of epilepsy following febrile convulsions was found to be higher, ifthe family history was positive for epilepsy (Livingston et al 1947, Bamberger andMatthes 1959). Moreover, the offspring of epileptic probands are at a higher risk to manifest febrile convulsions, especially ifthe children offemale epileptics are considered (Tsuboi and Endo 1977, Annegers et al 1976, Vot 18, Suppt I, 1987.…”

Section: Family Investigations In Corticoreticular Epilepsies With Prmentioning

confidence: 99%

Genetic Factors in Epilepsies with Primarily Generalized Minor Seizures

Doose

Baier

1987

Neuropediatrics

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“…Although a febrile convulsion may represent the only attack in a lifetime, the risk for epilepsy (i.e., recurrent seizures of any kind not triggered by fever) at a later stage is greater for children who have febrile convulsions than for those who do not (Bamberger and Matthes, 1959;Livingstone, 1954;Nelson and Ellenberg, 1976;Annegers et al, 1979). Therefore, although most febrile convulsions may not represent a serious health problem, those that are more prolonged and difficult to control are a serious challenge to preventive medicine because they are one of the most common causes of temporal lobe epilepsy.…”

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Induction of Epileptiform Activity by Temperature Elevation in Hippocampal Slices from Young Rats: An In Vitro Model for Febrile Seizures?

et al. 1992

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Extracellular field potential recordings were performed in the CA1 subfield of hippocampal slices obtained from Wistar rats aged 2-38 days. When the brain tissue was maintained at 35 degrees-36 degrees C (values obtained in the tissue chamber well), single-shock orthodromic stimuli elicited a response in the stratum pyramidale that consisted of a single population spike. In contrast, when the temperature in the well was increased to levels greater than 38.2 degrees C for periods of 5-15 min, the same type of stimuli elicited an epileptiform response characterized by a 250- to 600-ms-long, positive-going field potential with superimposed, multiple, negative-going population spikes. This potential resembled the epileptiform response recorded in the hippocampal slice in the presence of convulsants such as penicillin or bicuculline. Once the temperature was restored to control values (i.e., 35 degrees-36 degrees C) after induction of epileptiform activity, the abnormal response could be observed for less than or equal to 2 h. In some experiments (approximately one third of the successful trials), spontaneous epileptiform discharges appeared during and persisted after the increase in temperature. The ability of the hyperthermic period to induce epileptiform changes was age dependent: Epileptiform activity outlasting the period of temperature elevation was not observed in slices obtained from rats aged less than 4 days or greater than 28 days. Our data show that epileptiform activity can be induced by a transient increase in temperature and that the age of the animals from which slices are obtained plays an important role in the appearance of this phenomenon.(ABSTRACT TRUNCATED AT 250 WORDS)

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Cited by 5 publications

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Morphological Aspects of Aetiology and the Course of Infantile Spasms (West-Syndrome)¹

Morphological Aspects of Aetiology and the Course of Infantile Spasms (West-Syndrome)¹

Genetic Factors in Epilepsies with Primarily Generalized Minor Seizures

Induction of Epileptiform Activity by Temperature Elevation in Hippocampal Slices from Young Rats: An In Vitro Model for Febrile Seizures?

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Title Page / Vorwort / Inhaltsverzeichnis

Cited by 5 publications

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Morphological Aspects of Aetiology and the Course of Infantile Spasms (West-Syndrome)1

Morphological Aspects of Aetiology and the Course of Infantile Spasms (West-Syndrome)1

Genetic Factors in Epilepsies with Primarily Generalized Minor Seizures

Induction of Epileptiform Activity by Temperature Elevation in Hippocampal Slices from Young Rats: An In Vitro Model for Febrile Seizures?

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Morphological Aspects of Aetiology and the Course of Infantile Spasms (West-Syndrome)¹

Morphological Aspects of Aetiology and the Course of Infantile Spasms (West-Syndrome)¹