2019
DOI: 10.1136/annrheumdis-2019-216245
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Titre-specific positive predictive value of antinuclear antibody patterns

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Cited by 23 publications
(21 citation statements)
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“…The highest scores for clinical relevance were obtained for the centromere (AC-3) and homogeneous (AC-1) pattern, followed by the nuclear speckled (AC-2,4,5) and cytoplasmic reticular (AC-21) patterns. Especially the centromere pattern is associated with a speci c disease (limited systemic sclerosis, primary biliary cholangitis and Sjögren's syndrome) (16). It is the only pattern that has an almost absolute association with a restrict set of autoantibody speci cities (anti-CENP-B and/or anti-CENP-A).…”
Section: Discussionmentioning
confidence: 99%
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“…The highest scores for clinical relevance were obtained for the centromere (AC-3) and homogeneous (AC-1) pattern, followed by the nuclear speckled (AC-2,4,5) and cytoplasmic reticular (AC-21) patterns. Especially the centromere pattern is associated with a speci c disease (limited systemic sclerosis, primary biliary cholangitis and Sjögren's syndrome) (16). It is the only pattern that has an almost absolute association with a restrict set of autoantibody speci cities (anti-CENP-B and/or anti-CENP-A).…”
Section: Discussionmentioning
confidence: 99%
“…Cytoplasmic AC patterns were less frequently used in ANA IIF test result reporting than nuclear AC patterns. Among the competent cytoplasmic patterns ( brillar (AC- 15,16,17), speckled (AC- 18,19,20), reticular/ mitochondria-like (AC-21), polar/Golgi-like (AC-22), rods and rings (AC-23), the rods and rings pattern (AC-23) was the pattern that was least used (63% of the laboratories) ( Table 2).…”
Section: Characteristics Of the Participating Laboratories And Clinicmentioning
confidence: 99%
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“…It is anticipated that if a solid-phase test identifies the disease-specific target autoantigen, the clinical relevance can be further refined. The analyses by Vulsteke et al 2 elegantly illustrate that the positive predictive value (PPV) of the HEp-2 IIFA pattern can be further improved by taking into account the titre of the respective patterns. Given the value and importance of the large dataset (n=9851) obtained in this routine laboratory practice without any selection, except for studying only monospecific nuclear patterns, and the extensive analyses, it is unfortunate that the results have been condensed into a letter.…”
mentioning
confidence: 99%
“…Although currently not included in the ICAP classification, Luis Andrade recently presented observations on the HEp-2 substrate that suggested further differentiation within the AC-4 pattern grouping, distinguishing two AC-4 pattern variants with distinct association with anti-SS-A/Ro60 antibodies (14th Dresden Symposium on Autoantibodies). Another limitation of the restricted pattern assignment in the study of Vulsteke et al 2 is the exclusion of the cytoplasmic patterns as it would have been interesting to see how the titre contributes to the clinical interpretation of the cytoplasmic speckled patterns (AC-18, AC-19 and AC-20). In particular, the antisynthetase antibodies reveal only low to moderate titres.…”
mentioning
confidence: 99%