Tjipanazoles, new antifungal agents from the blue-green alga Tolypothrix tjipanasensis

Bonjouklian, Rosanne; Smitka, Tim A.; Doolin, Lawrence E.; Molloy, Robert; Debono, Manuel; Shaffer, Stacey; Moore, Richard E.; Stewart, Jeffrey B.; Patterson, Gregory M. L.

doi:10.1016/s0040-4020(01)81932-3

Cited by 137 publications

(95 citation statements)

References 15 publications

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“…Antibacterial and antifungal substances identified include fatty acids (Harder & Opperman, 1953;Findlay & Patil, 1984), glycolipids (Duff et al, 1966), acrylic acid (Sieburth, 1959), phenolics (De Cano et al, 1990), bromophenols (Pedersen & DaSilva, 1973), terpenoids, carbohydrates (Duff et al, 1966;Ramamurthy, 1970), N-glycosides (Bonjouklian et al, 1991), peptides (Berland et al, 1972), polysaccharides (Pesando & Gnassia-Garelli, 1979;Pesando et al, 1980), acrolyl-choline (Taylor et al, 1974, -diketone (Trick et al, 1984), isonitrile-containing indole alkaloids such as haploindole A (Fig. 2) (Moore et al, 1987) and various toxins such as nodularin, goniautoxin, saxitoxin, okadaic acid ( Fig.…”

Section: Antimicrobialsmentioning

confidence: 99%

Microalgae as sources of pharmaceuticals and other biologically active compounds

1995

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In the last decade the screening of microalgae, especially the cyanobacteria (blue-green algae), for antibiotics and pharmacologically active compounds has received ever increasing interest. A large number of antibiotic compounds, many with novel structures, have been isolated and characterised. Similarly many cyanobacteria have been shown to produce antiviral and antineoplastic compounds. A range of pharmacological activities have also been observed with extracts of microalgae, however the active principles are as yet unknown in most cases. Several of the bioactive compounds may find application in human or veterinary medicine or in agriculture. Others should find application as research tools or as structural models for the development of new drugs. The microalgae are particularly attractive as natural sources of bioactive molecules since these algae have the potential to produce these compounds in culture which enables the production of structurally complex molecules which are difficult or impossible to produce by chemical synthesis.

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Section: Antimicrobialsmentioning

confidence: 99%

Microalgae as sources of pharmaceuticals and other biologically active compounds

1995

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“…The result of toxic potentiality as obtained against fungal pathogens has also been supported the findings. Cyanobacteria produce biologically active compounds that have allelopathic and toxic activity against plant pathogens [16][17]. Kim and Kim (2008) [18] reported inhibition of F.oxysporum f. sp.…”

Section: Ethanolic Extract Methanolic Extract Carbendazimmancozebmentioning

confidence: 99%

In-Vitro Screening of Antifungal Activity of Cyanobacterial Extracts Against Some Phytopathogenic Fungi.

Shrivastava¹

2018

IJAR

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“…(21), isolated from Tolypothrix tjipanasensis. [141] These compounds share the same indolo[2,3-a]carbazole framework as other bioactive compounds such as staurosporine, [142][143][144] rebeccamycin (antitumor) [145,146] or the synthetic enzastaurin (LY317615, anti diabetes). [147,148] Unlike these derivatives from actinomycetes or slime molds, the tjipanazoles generally lack the pyrrolo [3,4- contrast to staurosporin/rebeccamycin, which is both an antitumor agent and a protein kinase C inhibitor.…”

Section: Indole Alkaloidsmentioning

confidence: 99%

Secondary Metabolites from Cyanobacteria: Complex Structures and Powerful Bioactivities

Gademann¹,

Portmann

2008

COC

237

168

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This review presents natural products from cyanobacteria. Several classes of secondary metabolites are highlighted. Toxic metabolites from these prokaryotic photosynthetic organisms include compounds such as microcystin, anatoxin and saxitoxin, which display hepatotoxicity and neurotoxicity. Their potential as drugs in cancer therapy is discussed based on the cryptophycin class of potent cytotoxic agents. The next part of this review highlights iron chelators from cyanobacteria, including schizokinen, synechobactin and anachelin. The biogenesis of anachelin is investigated as its mechanism of iron acquisition. Several indole alkaloids are then reviewed, from simple carbolines such as bauerines and nostocarboline to complex polycyclic structures such as hapalindole, welwitindolinone and ambiguine. The latter compounds present fascinating structure combined with powerful bioactivities and interesting biogenetic pathways. In the last part, protease inhibitors from cyanobacteria are discussed (cyanopeptolins, micropeptin and oscillapeptin) and their structure/activity relationships and selectivity for trypsin / chymotrypsin are presented. All these examples highlight the large structural variety of cyanobacterial metabolites combined with powerful biological activities. Cyanobacteria can thus be considered a prime source both for novel bioactive compounds and for leads for drugs.

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Tjipanazoles, new antifungal agents from the blue-green alga Tolypothrix tjipanasensis

Cited by 137 publications

References 15 publications

Microalgae as sources of pharmaceuticals and other biologically active compounds

Microalgae as sources of pharmaceuticals and other biologically active compounds

In-Vitro Screening of Antifungal Activity of Cyanobacterial Extracts Against Some Phytopathogenic Fungi.

Secondary Metabolites from Cyanobacteria: Complex Structures and Powerful Bioactivities

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