Tl-201 Chloride and Tc-99m MIBI Accumulation in Lung Adenocarcinoma in Patients With and Without Distant Metastases

Yamamoto, Yuka; Nishiyama, Yoshihiro; Fukunaga, Kotaro; Satoh, Katashi; Ohkawa, Motoomi

doi:10.1097/00003072-200109000-00002

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…Therefore, our finding (radiotracer activity corresponding to the region of pleural effusion) could be explained by radiotracer uptake by the malignant cells of the effusion, a phenomenon which is widely described previously [7][8][9].…”

Section: Discussionsupporting

confidence: 70%

Incidental Detection of Malignant Pleural Effusion on Sestamibi Myocardial Perfusion Scan

Eftekhari

Gholamrezanezhad

2006

Int J Cardiovasc Imaging

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Incidentally the diagnosis of pleural effusions can be made with scintigraphic studies. We report a case of incidental detection of pleural effusion in sestamibi myocardial perfusion scan. A 64-year-old man with a history of chest pain was referred for Sestamibi myocardial perfusion scintigraphy. The review of cine data revealed an area of radiotracer accumulation in the left hemithorax. Subsequent chest X-ray and computed tomography revealed a relatively massive pleural effusion. Microscopic evaluation confirmed the malignant nature of pleural effusion, the origin of which was an ipsilateral pulmonary adenocarcinoma. As to our knowledge, it is the first report of sestamibi uptake in pleural effusion fluid. In our opinion, this finding could be explained by radiotracer uptake in the malignant component of the effusion. Reporting of these incidental findings could be important and sometimes can be resulted in determining previously unknown pathologies.

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Section: Discussionsupporting

confidence: 70%

Incidental Detection of Malignant Pleural Effusion on Sestamibi Myocardial Perfusion Scan

Eftekhari

Gholamrezanezhad

2006

Int J Cardiovasc Imaging

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“…In addition to CT, Tl-201 SPECT has been reported to be useful in the evaluation of mediastinal node involvement in lung cancer. 12 –14 In our results, however, the use of Tl-201 SPECT alone in the evaluation of mediastinal node involvement was not favorable. Furthermore, the location of abnormal Tl-201 accumulation was only roughly estimated and could not be evaluated precisely according to the lymph node mapping system.…”

Section: Discussioncontrasting

confidence: 62%

“…Previous studies have been performed to evaluate the accuracy of CT or Tl-201 SPECT in the evaluation of mediastinal node involvement. 3 –10,12 –14 However, most of these studies demonstrated a diagnostic value of single examination separately, and very little attention has been given to the combined examination with CT, Tl-201 SPECT and serum CEA level. Our results show that the combined examination of mediastinal nodal involvement with CT, Tl-201 SPECT and serum CEA level might increase underestimation, but decrease overestimation.…”

Section: Discussionmentioning

confidence: 99%

“…Other previous studies reported that thallium-201 single photon emission computed tomography (Tl-201 SPECT) is useful in evaluation of mediastinal node metastasis in non-small cell lung cancer. 12 –14 Elevated preoperative serum carcinoembryonic antigen (CEA) levels have been also reported as a clinical predictor of N2 disease in non-small cell lung cancer. 15,16…”

Section: Introductionmentioning

confidence: 99%

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Combined Procedures for Mediastinal Staging in Non-Small Cell Lung Cancer

Tomita

Matsuzaki

Edagawa

et al. 2004

Asian Cardiovasc Thorac Ann

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We investigated whether the combined use of computed tomography, thallium-201 single photon emission computed tomography and serum carcinoembryonic antigen level improves preoperative non-invasive mediastinal. 128 consecutive non-small cell lung cancer patients (85 adenocarcinomas, 31 squamous cell carcinomas and 12 others) who underwent a surgical resection were enrolled in this study. The results of the combined procedures were compared with the pathologic findings. Our results showed that the combined evaluation of mediastinal nodal involvement with the three procedures might increase underestimation, but decrease overestimation as compared to computed tomography alone. Thallium-201 single photon emission computed tomography for patients with enlarged nodes at computed tomography showed 81.3% and 100% of positive predictive value in overall and squamous cell carcinoma patients, respectively. The negative predictive value of thallium-201 single photon emission computed tomography for patients without enlarged nodes at computed tomography was highly accurate in adenocarcinoma (93.9%) as well as squamous cell carcinoma (94.4%). Combining computed tomography findings and serum carcinoembryonic antigen level had a poor predictive value. However, in patients with adenocarcinoma, a negative examination was highly accurate (95.2%). In conclusion, our results show a trend that combined use of the three procedures might improve non-invasive mediastinal staging in non-small cell lung cancer.

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PET and SPECT in the management of lung cancer

Sarinas

Chitkara²

2002

Current Opinion in Pulmonary Medicine

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Lung cancer is the leading cause of cancer deaths in men and women. Most recently in 2001, the Health Care Financing Administration has expanded Medicare coverage for positron emission tomography (PET) to include the diagnosis, staging, and restaging of lung cancer. This review discusses the current metabolic imaging techniques, including the role of PET, single-photon emission computed tomography (SPECT), and the new hybrid PET in the diagnosis, staging, and treatment of lung cancer. The technological advantages, disadvantages, and benefits are compared. PET has the highest detection efficiency than gamma camera based devices. PET when merged with computed tomography (CT) forms the powerful hybrid PET-CT system, capable both of metabolic and anatomic imaging. Clinical imaging pathways based on these newer modalities for the management of lung cancer are proposed. Technological advances in metabolic imaging linked with therapy driven protocols and outcomes may further provide cutting edge modalities that positively impact on dismal lung cancer mortality statistics.

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Tl-201 Chloride and Tc-99m MIBI Accumulation in Lung Adenocarcinoma in Patients With and Without Distant Metastases

Abstract: Tl-201 chloride SPECT may be more effective than Tc-99m MIBI SPECT for evaluating the distant metastatic potential of primary lung adenocarcinoma.

Cited by 5 publications

References 20 publications

Incidental Detection of Malignant Pleural Effusion on Sestamibi Myocardial Perfusion Scan

Incidental Detection of Malignant Pleural Effusion on Sestamibi Myocardial Perfusion Scan

Combined Procedures for Mediastinal Staging in Non-Small Cell Lung Cancer

PET and SPECT in the management of lung cancer

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