TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics

Fore, Faith; Indriputri, Cut; Mamutse, Janet; Nugraha, Jusak

doi:10.4110/in.2020.20.e21

Cited by 76 publications

(60 citation statements)

References 50 publications

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“…CD22 is an important drug target for ameliorating autoimmune diseases and acute lymphoblastic leukemia 36 , 37 . TLR-10 is a pattern recognition receptor with anti-inflammatory properties 38 . Kopp et al found that TLRs are associated with colorectal cancer via nuclear transcription factor-κB-initiated transcription of inflammatory genes 39 .…”

Section: Discussionmentioning

confidence: 99%

Tumor mutation burden (TMB)-associated signature constructed to predict survival of lung squamous cell carcinoma patients

Duan

Chen

2021

Sci Rep

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Lung squamous cell carcinoma (LUSC) is a common type of lung cancer with high incidence and mortality rate. Tumor mutational burden (TMB) is an emerging biomarker for selecting patients with non-small cell lung cancer (NSCLC) for immunotherapy. This study aimed to reveal TMB involved in the mechanisms of LUSC and develop a model to predict the overall survival of LUSC patients. The information of patients with LUSC were obtained from the cancer genome atlas database (TCGA). Differentially expressed genes (DEGs) between low- and the high-TMB groups were identified and taken as nodes for the protein–protein interaction (PPI) network construction. Gene oncology (GO) enrichment analysis and gene set enrichment analysis (GSEA) were used to investigate the potential molecular mechanism. Then, we identified the factors affecting the prognosis of LUSC through cox analysis, and developed a risk score signature. Kaplan–Meier method was conducted to analyze the difference in survival between the high- and low-risk groups. We constructed a nomogram based on the risk score model and clinical characteristics to predict the overall survival of patients with LUSC. Finally, the signature and nomogram were further validated by using the gene expression data downloaded from the Gene Expression Omnibus (GEO) database. 30 DEGs between high- and low-TMB groups were identified. PPI analysis identified CD22, TLR10, PIGR and SELE as the hub genes. Cox analysis indicated that FAM107A, IGLL1, SELE and T stage were independent prognostic factors of LUSC. Low-risk scores group lived longer than that of patients with high-risk scores in LUSC. Finally, we built a nomogram that integrated the clinical characteristics (TMN stage, age, gender) with the three-gene signature to predict the survival probability of LUSC patients. Further verification in the GEO dataset. TMB might contribute to the pathogenesis of LUSC. TMB-associated genes can be used to develope a model to predict the OS of lung squamous cell carcinoma patients.

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Section: Discussionmentioning

confidence: 99%

Tumor mutation burden (TMB)-associated signature constructed to predict survival of lung squamous cell carcinoma patients

Duan

Chen

2021

Sci Rep

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“…The function of TLR10 is inhibitory, whereas TLR1, TLR2 and TLR6 promote the innate immune responses. 15 A recent study evaluated whether TLR10 modulates the induction of immunity induced by BCG. 16 The figure 0 was replaced by 1 in analyses to allow the p value calculation.…”

Section: Discussionmentioning

confidence: 99%

“…TLR1, TLR6 and TLR10 act as co‐receptors for TLR2, and therefore, these four TLRs are called as a TLR2 subfamily. The function of TLR10 is inhibitory, whereas TLR1, TLR2 and TLR6 promote the innate immune responses 15 . A recent study evaluated whether TLR10 modulates the induction of immunity induced by BCG 16 .…”

Section: Discussionmentioning

confidence: 99%

Toll‐like receptor 10 rs10004195 variation may be protective against Bacillus Calmette‐Guérin osteitis after newborn vaccination

Korppi¹,

Teräsjärvi

Lauhkonen³

et al. 2020

Acta Paediatrica

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Aim Toll‐like receptor 1 (TLR1), TLR2, TLR6 and TLR10 form the TLR2 subfamily. In our previous controlled studies in 132 subjects with osteitis after newborn Bacillus Calmette‐Guérin (BCG) vaccination, TLR1, TLR2 and TLR6 variations were associated with the risk of BCG osteitis. Now, we evaluated the role of ten single nucleotide polymorphisms (SNP) of the TLR10 gene in this cohort. Methods Five synonymous TLR10 SNPs (rs10004195, rs10856837, rs10856838, rs1109695 and rs11466652), and five missense TLR10 SNPs (rs11096955, rs11096957, rs11466649, rs11466653 and rs11466658) were determined by polymerase chain reaction (PCR)‐based sequencing in 132 former BCG osteitis patients. Results TLR10 rs10004195 polymorphism was associated with the risk of BCG osteitis, compared to Finnish population controls. The variant genotype (AT/AA) was present in 13.6% of cases versus 26.2% of controls (p = 0.024). Correspondingly, the minor allele frequency (MAF) was lower (0.075) in cases than in controls (0.152; p = 0.009). There were no significant differences in the genotypes of the other nine studied TLR10 SNPs or in the corresponding MAFs between cases and controls. Conclusion Among ten studied TLR10 gene polymorphisms, the variation only in the TLR10 rs10004195 was associated with the BCG osteitis risk after newborn BCG vaccination.

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“…To our knowledge, TLR10, another member of the TLR2 subfamily, has high structural homology with TLR1 and TLR6. It can homo-dimerize or heterodimerize with TLR1 and TLR2 (Fore et al 2020 ; Xiang et al 2020 ). Nevertheless, the research on the ligand recognition, signal pathway, and biological function of TLR10 is not comprehensive yet.…”

Section: Lipoprotein Is the Predominant Ligand For The Tlr2 Subfamilymentioning

confidence: 99%

Research progress on Toll-like receptor signal transduction and its roles in antimicrobial immune responses

Xia

Lian

et al. 2021

Appl Microbiol Biotechnol

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When microorganisms invade a host, the innate immune system first recognizes the pathogen-associated molecular patterns of these microorganisms through pattern recognition receptors (PRRs). Toll-like receptors (TLRs) are known transmembrane PRRs existing in both invertebrates and vertebrates. Upon ligand recognition, TLRs initiate a cascade of signaling events; promote the pro-inflammatory cytokine, type I interferon, and chemokine expression; and play an essential role in the modulation of the host’s innate and adaptive immunity. Therefore, it is of great significance to improve our understanding of antimicrobial immune responses by studying the role of TLRs and their signal molecules in the host’s defense against invading microbes. This paper aims to summarize the specificity of TLRs in recognition of conserved microbial components, such as lipoprotein, lipopolysaccharide, flagella, endosomal nucleic acids, and other bioactive metabolites derived from microbes. This set of interactions helps to elucidate the immunomodulatory effect of TLRs and the signal transduction changes involved in the infectious process and provide a novel therapeutic strategy to combat microbial infections.

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TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics

Cited by 76 publications

References 50 publications

Tumor mutation burden (TMB)-associated signature constructed to predict survival of lung squamous cell carcinoma patients

Tumor mutation burden (TMB)-associated signature constructed to predict survival of lung squamous cell carcinoma patients

Toll‐like receptor 10 rs10004195 variation may be protective against Bacillus Calmette‐Guérin osteitis after newborn vaccination

Research progress on Toll-like receptor signal transduction and its roles in antimicrobial immune responses

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