TLR4 signaling: A potential therapeutic target in ischemic coronary artery disease

Jia, Sujie; Niu, Panpan; Cong, Junzi; Zhang, Bikui; Zhao, Ming‐Hui

doi:10.1016/j.intimp.2014.08.011

Cited by 61 publications

(46 citation statements)

References 82 publications

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“…[142][143][144][145][146][147] Identification and characterization of common epigenetic outcomes linked to disease manifestations and their interaction with nutrient status may allow the development of specific treatment and intervention measures. [148][149][150][151] Interestingly, the effect of limited or oversaturated nutrient bioavailability on epigenetic states is complex and not necessarily direct. For example, deficiency of methyl donors results in hypermethylation at some loci and hypomethylation at others.…”

Section: Role Of Nutrition In Epigenetic Perturbationmentioning

confidence: 99%

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment

Ferguson¹,

Allayee²,

Gerszten³

et al. 2016

Circ Cardiovasc Genet

101

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Abstract-Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple "omic" measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome. Here, we describe the current state of the field of nutrigenomics with respect to cardiometabolic disease research and outline a direction for the integration of multiple omics techniques in future nutrigenomic studies aimed at understanding mechanisms and developing new therapeutic options for cardiometabolic disease treatment and prevention. The interpretation and scope of nutrigenomics may vary, but it can be thought to encompass the spectrum of nutritional genomics research, including classic nutrigenetics studies of gene-diet interactions and molecular nutrition, in vitro and in vivo models, human nutrition studies, and the application of largescale, unbiased studies using high-throughput "omics" techniques to study the effects of nutrients on the body. 6 As the Figure shows, diet and the genome may influence cardiometabolic health through a variety of interconnected intermediates, perturbations in which can be measured through omics technologies, including RNA expression (transcriptome), epigenetic modifications (epigenome), metabolites (metabolome), lipids (lipidome), proteins (proteome), and resident microbial communities (microbiome). Although it is clear that both nutrients and genes play a distinct role in determining health, the complex interactions among genes, diet, and downstream networks are not well understood. The application of nutrigenomics approaches to questions of human health and disease is an important component in understanding the complexities of the interplay between basic metabolic processes and externalThe American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This statement was approved by the American Heart Association Science Advisory and Coordinating Committee on January 22, 2016, and the American Heart Association Executive Committee on February 23, 2016. A copy of the document is available at http://professional.heart.org/statements by using either "Search for Guidelines & Statements" or the "Browse by Topic" area. To purchase additional reprints, call 843-216-2533 or e-mail kelle.ramsay@ wolterskluwer.com.The...

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Section: Role Of Nutrition In Epigenetic Perturbationmentioning

confidence: 99%

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment

Ferguson¹,

Allayee²,

Gerszten³

et al. 2016

Circ Cardiovasc Genet

101

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“…Although risk factors, such as genetics, unhealthy diet, smoking, sedentary lifestyle, hyperlipemia, obesity, hypertension, and diabetes mellitus, have been well documented, the precise mechanisms responsible for CAD remain obscure. Previous researchers have reported that CAD is a chronic inflammatory process, suggesting that inflammatory cytokines play a major role in the progression of CAD [2,3]. Interleukin-6 (IL-6), as a pleiotropic cytokine of 23.7 kDa, is one of the important inflammatory cytokines and regulates the inflammatory response of CAD [4,5].…”

Section: Introductionmentioning

confidence: 99%

Association of interleukin-6 gene polymorphism with coronary artery disease: an updated systematic review and cumulative meta-analysis

Hou

Chen

Sun³

et al. 2015

Inflamm. Res.

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“…Their study showed higher MPA levels in subjects with coronary endothelium dysfunction (identified by paradoxical vasoconstriction in response to rapid pacing) and an inverse correlation between the 2 parameters, although there was no association between levels of MPA and the presence of flowlimiting disease (FFR ≤80) or the extent of disease (1, 2 or 3 vessels). 3,17 Indeed, a previous study found that Mon3 (CD14 dim ) monocytes did not express CCR2 at all and, in comparison with Mon2, produced no reactive oxygen species and expressed little mRNA for myeloperoxidase and lysozyme in response to TLR4, indicating that Mon2 monocytes produce most of the proinflammatory cytokines in that setting. There were, however, some limitations to this study including small sample size (11 males).…”

Section: Discussionmentioning

confidence: 97%

Impact of Mon2 monocyte‐platelet aggregates on human coronary artery disease

Brown

Lip

Varma

et al. 2018

Eur J Clin Investigation

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TLR4 signaling: A potential therapeutic target in ischemic coronary artery disease

Cited by 61 publications

References 82 publications

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment

Association of interleukin-6 gene polymorphism with coronary artery disease: an updated systematic review and cumulative meta-analysis

Impact of Mon2 monocyte‐platelet aggregates on human coronary artery disease

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