TMEM Proteins in Cancer: A Review

Schmit, Kathleen; Michiels, Carine

doi:10.3389/fphar.2018.01345

Cited by 170 publications

(157 citation statements)

References 73 publications

Supporting

Mentioning

156

Contrasting

Order By: Relevance

“…In addition to sex chromosome-encoded genes, several autosomal genes were up-regulated in adenomas from male patients; of note, PDLIM2, PENK, SOX4, FH, PTMA and TMEM97 are all associated with tumourigenesis [64][65][66][67][68][69], and thus could play a role in the less favourable course of corticotrope adenomas in male patients. Links between these factors and the pituitary are known for PTMA and SOX4, as PTMA nuclear staining has been linked to pituitary tumour size [70], and SOX4 is involved in pituitary development, as shown in both zebrafish [71] and human tissues [72].…”

Section: Discussionmentioning

confidence: 99%

Sexual Dimorphism in Cellular and Molecular Features in Human ACTH-Secreting Pituitary Adenomas

Giraldi

Cassarino

Sesta

et al. 2020

Cancers

View full text Add to dashboard Cite

(1) Background. Cushing’s disease presents gender disparities in prevalence and clinical course. Little is known, however, about sexual dimorphism at the level of the corticotrope adenoma itself. The aim of the present study was to evaluate molecular features of ACTH-secreting pituitary adenomas collected from female and male patients with Cushing’s disease. (2) Methods. We analyzed 153 ACTH-secreting adenomas collected from 31 men and 122 women. Adenomas were established in culture and ACTH synthesis and secretion assessed in basal conditions as well as during incubation with CRH or dexamethasone. Concurrently, microarray analysis was performed on formalin-fixed specimens and differences in the expression profiles between specimens from male and female patients identified. (3) Results. ACTH medium concentrations in adenomas obtained from male patients were significantly lower than those observed in adenomas from female patients. This could be observed for baseline as well as modulated secretion. Analysis of corticotrope transcriptomes revealed considerable similarities with few, selected differences in functional annotations. Differentially expressed genes comprised genes with known sexual dimorphism, genes involved in tumour development and genes relevant to pituitary pathophysiology. (4) Conclusions. Our study shows for the first time that human corticotrope adenomas present sexual dimorphism and underlines the need for a gender-dependent analysis of these tumours. Differentially expressed genes may represent the basis for gender-tailored target therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Sexual Dimorphism in Cellular and Molecular Features in Human ACTH-Secreting Pituitary Adenomas

Giraldi

Cassarino

Sesta

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

“…Similarly, Reverter et al (2016) found an association between the SNP ARS-BFGL-NGS-116714 in the coding region of the TMEM27 gene and some fertility indicators in Brahman cows. In humans, the TMEM50A gene was reported like a tumor suppressor (Schmit and Michiels, 2018). Nevertheless, the TMEM18 (BTA2) and TMEM38B (BTA9) genes were associated with the first menstruation of women (Chizu et al 2013), indicating the strong association between transmembrane genes and reproductive traits.…”

Section: Discussionmentioning

confidence: 99%

Research Article Genomic association study for adaptability traits in four Colombian cattle breeds

León¹,

Manrique²,

Martínez³

et al. 2019

Genet. Mol. Res.

View full text Add to dashboard Cite

The aim of this study was to perform a genome wide association study for the coefficient of adaptability, the heat tolerance coefficient, age at first calving and calving interval, using 58,868 and 57,482 single nucleotide polymorphisms obtained from 1262 Blanco Orejinegro and 742 Sanmartinero individuals, implementing a singlestep-genomic-BLUP (ssGBLUP) methodology. A total of 25 and 11 genomic regions in BON and SM were associated with the traits evaluated. In these regions; several genes involved in the regulation of reproduction and adaptability were identified. Some of them, such as the RPTOR, TM2D1, RAB21 and ACOT13 genes, are involved in the physiological response to heat stress. SLC6A16, TMEM50A, NLRP9, KHDRBS2 and UBE2C are possibly associated to reproductive performance. The results of this study indicate an association between some genomic regions and reproductive and adaptability-related traits in Colombian cattle breeds. Several genes contained in these regions can potentially be used in animal breeding programs to select for adabtability within cattle production systems located in a tropical environment.

show abstract

“…Transmembrane (TMEM) proteins are a kind of integral membrane proteins existing in the total biological membrane, which are characterized by multi‐pass transmembrane domains. TMEM45A, belonging to this large family, has recently been reported to be closely related with tumorigenesis, progression of malignancy, and even chemoresistance . It has been confirmed as an epigenetically regulatory gene in breast cancer MCF‐7 cells .…”

Section: Introductionmentioning

confidence: 99%

Knockdown of TMEM45A overcomes multidrug resistance and epithelial–mesenchymal transition in human colorectal cancer cells through inhibition of TGF‐β signalling pathway

Zhu

Jiang

Yan

et al. 2019

Clin Exp Pharma Physio

View full text Add to dashboard Cite

Colorectal cancer (CRC), a leading cause of cancer death, has recently been known as the most prevalent malignancy worldwide. Although chemotherapy is an important therapeutic option for CRC patients, multidrug resistance (MDR) still remains a major cause of chemotherapy failure. Transmembrane protein 45A (TMEM45A) has been found highly expressed in various cancers, and is also proposed as an interesting biomarker for chemoresistance. However, the association between TMEM45A and MDR in CRC remains unclear. This study aimed to investigate the key role of TMEM45A in CRC by knockdown of its expression in 5-FU-resistant CRC cells (HCT-8/5-FU and SW480/5-FU) and their parental cells (HCT-8 and SW480). Data showed that TMEM45A was significantly up-regulated in HCT-8/5-FU and SW480/5-FU cells in comparison with their parental HCT-8 and SW480 cells. Knockdown of TMEM45A enhanced 5-FU sensitivity and 5-FU-induced apoptosis in HCT-8/5-FU and SW480/5-FU cells. It was also found that inhibition of TMEM45A increased the intracellular accumulation of Rhodamine-123 and down-regulated the expression of MDR1 in HCT-8/5-FU and SW480/5-FU cells. In addition, knockdown of TMEM45A suppressed migration and invasion of HCT-8/5-FU and SW480/5-FU cells. Furthermore, knockdown of TMEM45A not only attenuated MDR-enhanced epithelial-mesenchymal transition (EMT), but also suppressed MDR-enhanced activation of the TGF-β signalling pathway in HCT-8/5-FU and SW480/5-FU cells. Taken together, our study suggests that knockdown of TMEM45A can effectively overcome MDR and inhibit EMT via suppression of the TGF-β signalling pathway in human CRC cells, and that targeting TMEM45A will be a potential strategy in the treatment of MDR in CRC. K E Y W O R D S colorectal cancer, epithelial-mesenchymal transition, multidrug resistance, Smad, TGF-β, TMEM45A S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Zhu M, Jiang B, Yan D, Wang X, Ge H, Sun Y. Knockdown of TMEM45A overcomes multidrug resistance and epithelial-mesenchymal transition in human colorectal cancer cells through inhibition of TGF-β signalling pathway. Clin Exp Pharmacol Physiol. 2020;47:503-516. https ://

show abstract

TMEM Proteins in Cancer: A Review

Cited by 170 publications

References 73 publications

Sexual Dimorphism in Cellular and Molecular Features in Human ACTH-Secreting Pituitary Adenomas

Sexual Dimorphism in Cellular and Molecular Features in Human ACTH-Secreting Pituitary Adenomas

Research Article Genomic association study for adaptability traits in four Colombian cattle breeds

Knockdown of TMEM45A overcomes multidrug resistance and epithelial–mesenchymal transition in human colorectal cancer cells through inhibition of TGF‐β signalling pathway

Contact Info

Product

Resources

About