TMEM100 Regulates Neuropathic Pain by Reducing the Expression of Inflammatory Factors

Guo, Zhaoyang; Zhu, Guang; Fan, Zuoran; Shen, Nana; Qi, Xiaoying; Ma, Yuanye; Zhu, Yi; Wu, Xiaolin; Chen, Bohua; Xiang, Hongfei

doi:10.21203/rs.3.rs-2358317/v1

“…For the response curve of the barrel temperature control, this paper uses a transfer function in the form of a first order inertia link plus a pure delay that can meet the control system requirements [22]. The corresponding parameters of the extruder barrel temperature control system are obtained by means of experimental parameter identi-fication.…”

Section: Modelling Of Temperature Control Systems For Plastic Extrudersmentioning

confidence: 99%

Research and application of adaptive anti-interference based VU-fuzzy-PID algorithm in temperature control system of platic extruder

Meng,

Sun,

Ruan

et al. 2024

Preprint

0

View full text Add to dashboard Cite

Plastic profiles, as the basic material for social and economic development, are mainly processed and moulded by plastic extruders. In the production process of plastic profiles, the temperature precision control of plastic extruder directly affects the plasticising and mixing effect of raw mate-rials. Therefore, the development of high-precision, fast response and stable plastic extruder tem-perature control system plays a key role in the development of plastic profile industry. In order to solve the shortcomings of the plastic extruder such as low temperature precision, slow response speed and poor anti-interference ability, the author has established a plastic extruder temperature control system model based on the study of PID control strategies and fuzzy PID control strategies, combined with the structural and functional characteristics of plastic extruder. Adopting a variable universe fuzzy PID control strategy to improve the performance of the plastic extruder temperature control system. The core idea of this strategy is to introduce proportional factors to change the range of the fuzzy domain. Under the condition that the fuzzy rules remain unchanged, the fuzzy domain compresses as the error decreases and expands as the error increases. Changing the domain is equivalent to adding fuzzy control rules within the same domain, thereby completing the dynamic adjustment of PID controller parameters. Through MATLAB simulation analysis and comparison, it was found that this control strategy has the advantages of short rise time, no overshoot, and strong anti-interference compared to PID control and fuzzy PID control strategies. Finally, through ex-perimental verification, it was found that this control strategy significantly changes the temperature control effect of nonlinear time-varying extruders, and has good adaptability and stability.

show abstract

“…For the response curve of the barrel temperature control, this paper uses a transfer function in the form of a first order inertia link plus a pure delay that can meet the control system requirements [22]. The corresponding parameters of the extruder barrel temperature control system are obtained by means of experimental parameter identification.…”

Section: Modelling Of Temperature Control Systems For Plastic Extrudersmentioning

confidence: 99%

Research and Application of Plastic Extruder Temperature System Based on Variable Universe Fuzzy PID Control

Meng

¹

,

Gao

²

,

Ruan

³

et al. 2023

Preprint

0

View full text Add to dashboard Cite

Plastic profiles, as the basic material for social and economic development, are mainly processed and moulded by plastic extruders. In the production process of plastic profiles, the temperature precision control of plastic extruder directly affects the plasticising and mixing effect of raw mate-rials. Therefore, the development of high-precision, fast response and stable plastic extruder tem-perature control system plays a key role in the development of plastic profile industry. In order to solve the shortcomings of the plastic extruder such as low temperature precision, slow response speed and poor anti-interference ability, the author has established a plastic extruder temperature control system model based on the study of PID control strategies and fuzzy PID control strategies, combined with the structural and functional characteristics of plastic extruder. Adopting a variable universe fuzzy PID control strategy to improve the performance of the plastic extruder temperature control system. The core idea of this strategy is to introduce proportional factors to change the range of the fuzzy domain. Under the condition that the fuzzy rules remain unchanged, the fuzzy domain compresses as the error decreases and expands as the error increases. Changing the domain is equivalent to adding fuzzy control rules within the same domain, thereby completing the dynamic adjustment of PID controller parameters. Through MATLAB simulation analysis and comparison, it was found that this control strategy has the advantages of short rise time, no overshoot, and strong anti-interference compared to PID control and fuzzy PID control strategies. Finally, through ex-perimental verification, it was found that this control strategy significantly changes the temperature control effect of nonlinear time-varying extruders, and has good adaptability and stability.

show abstract

“…A preprint has previously been published [ https://www.researchsquare.com/article/rs-2358317/v1 ] [ 50 ].…”

Section: Disclosurementioning

confidence: 99%

TMEM100 Regulates Neuropathic Pain by Reducing the Expression of Inflammatory Factors

Cui

¹

,

Guo

²

,

Guo

³

et al. 2023

Mediators of Inflammation

Self Cite

1

0

View full text Add to dashboard Cite

There is no effective treatment for peripheral nerve injury-induced chronic neuropathic pain (NP), which profoundly impacts the quality of life of those affected. Transmembraneprotein100 (TMEM100) is considered to be a pain regulatory protein and is expressed in the dorsal root ganglion (DRG) of rats. However, the mechanism of pain regulation and the expression of TMEM100 following various peripheral nerve injuries are unclear. In this study, we constructed two pain models of peripheral nerve injury: tibial nerve injury (TNI) and chronic constriction injury (CCI). This study found that the Paw Withdrawal Mechanical Threshold (PWMT) and Paw Withdraw Thermal Latency (PWTL) of the rats in the two pain models decreased significantly, and the expression of TMEM100 in the DRG of two groups also decreased significantly. Furthermore, the decrease in the CCI group was more obvious than in the TNI group. There was no significant statistical significance ( P > 0.05 ). We constructed an adeno-associated virus 6 (AAV6) vector expressing recombinant fluorescent TMEM100 protein and injected it into the sciatic nerve (SN) of two pain models: CCI and TNI. PWMT and PWTL were significantly increased in the two groups, along with the expression of TMEM100 in the spinal cord and DRG. It also significantly inhibited the activation of microglia, astrocytes, and several inflammatory mediators (TNF- α, IL-1 β, and IL-6). In summary, the results of this study suggested that TMEM100 might be a promising molecular strategy for the treatment of NP, and its anti-inflammatory effects might play an important role in pain relief.

show abstract

TMEM100 Regulates Neuropathic Pain by Reducing the Expression of Inflammatory Factors

Cited by 3 publications

References 46 publications

Research and application of adaptive anti-interference based VU-fuzzy-PID algorithm in temperature control system of platic extruder

Research and application of adaptive anti-interference based VU-fuzzy-PID algorithm in temperature control system of platic extruder

Research and Application of Plastic Extruder Temperature System Based on Variable Universe Fuzzy PID Control

TMEM100 Regulates Neuropathic Pain by Reducing the Expression of Inflammatory Factors

Contact Info

Product

Resources

About