TMEM16A-encoded anoctamin 1 inhibition contributes to chrysin-induced coronary relaxation

Ma, Guijin; Zhang, Jiangtao; Yang, Xiaomin; Guo, Pengmei; Hou, Xiaomin; Fan, Yanying; Liu, Yu; Zhang, Mingsheng

doi:10.1016/j.biopha.2020.110766

Cited by 5 publications

(4 citation statements)

References 56 publications

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“…This activity could be used in the treatment of diseases with an etiology associated with vasomotor dysfunctions, such as hypertension or stroke. In addition, chrysin in mitoxantrone cardiotoxicity studies in a mouse model reduced cardiomyocyte apoptosis and loss of intermediate filaments, which may indicate its anti-apoptotic properties and their importance in cardioprotective action [24,42,43].…”

Section: Cardioprotective Activitymentioning

confidence: 94%

Therapeutic potential of flavonoids used in traditional Chinese medicine – a comparative study of galangin, kaempferol, chrysin and fisetin

Sokal,

Stocerz,

Olczyk

et al. 2024

Ann. Acad. Med. Siles.

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Ziołolecznictwo stanowi jedną z głównych gałęzi tradycyjnej medycyny chińskiej (<i>traditional Chinese medicine</i> – TCM). W pracy skupiono się na aktywności biologicznej wybranych flawonoidów, a także konkretnych przykładach wpływu tych substancji na różne układy organizmu. Flawonoidy to grupa związków chemicznych zawartych w surowcach roślinnych, miodzie, propolisie czy grzybach stosowanych w TCM. Chryzyna, galangina, kemferol i fisetyna to przykłady flawonoidów wykazujących m.in. właściwości przeciwutleniające, przeciwzapalne czy przeciwbakteryjne. Właściwości te są przedmiotem wielu badań naukowych, mających na celu zbadanie ich potencjalnego działania terapeutycznego.

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Section: Cardioprotective Activitymentioning

confidence: 94%

Therapeutic potential of flavonoids used in traditional Chinese medicine – a comparative study of galangin, kaempferol, chrysin and fisetin

Sokal,

Stocerz,

Olczyk

et al. 2024

Ann. Acad. Med. Siles.

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“…According to the previous experimental method ( Ma et al, 2020 ), we evaluated the effects of DBD, ASR, and AR on MCA contraction induced by the release of internal Ca 2+ from organelles such as the endoplasmic reticulum and mitochondria into the cytoplasmic matrix ([Ca 2+ ] in ). After incubating the MCA vessels with EGTA containing the Ca 2+ -free PSS fluid for 10 min to remove intracellular Ca 2+ , the vessels were then administered with the EGTA- and Ca 2+ -free PSS fluids containing DBD, ASR, and AR (64 mg/ml) for 10 min.…”

Section: Methodsmentioning

confidence: 99%

Anticonstriction Effect of MCA in Rats by Danggui Buxue Decoction

et al. 2021

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Objective: Danggui Buxue decoction (DBD), consisting of Angelicae Sinensis Radix (ASR) and Astragali Radix (AR), is a famous prescription with the function of antivasoconstriction. This study intends to probe its mechanisms on the relaxation of the middle cerebral artery (MCA).Methods: Vascular tension of rat MCA was measured using a DMT620 M system. First, the identical series of concentrations of DBD, ASR, and AR were added into resting KCl and U46619 preconstricted MCA. According to the compatibility ratio, their dilatation effects were further investigated on KCl and U46619 preconstricted vessels. Third, four K+ channel blockers were employed to probe the vasodilator mechanism on KCl-contracted MCA. We finally examined the effects of DBD, ASR, and AR on the vascular tone of U46619-contracted MCA in the presence or absence of Ca2+.Results: Data suggested that DBD, ASR, and AR can relax on KCl and U46619 precontracted MCA with no effects on resting vessels. The vasodilator effect of ASR was greater than those of DBD and AR on KCl-contracted MCA. For U46619-contracted MCA, ASR showed a stronger vasodilator effect than DBD and AR at low concentrations, but DBD was stronger than ASR at high concentrations. Amazingly, the vasodilator effect of DBD was stronger than that of AR at all concentrations on two vasoconstrictors which evoked MCA. The vasodilator effect of ASR was superior to that of DBD at a compatibility ratio on KCl-contracted MCA at low concentrations, while being inferior to DBD at high concentrations. However, DBD exceeded AR in vasodilating MCA at all concentrations. For U46619-constricted MCA, DBD, ASR, and AR had almost identical vasodilation. The dilation of DBD and AR on KCl-contracted MCA was independent of K+ channel blockers. However, ASR may inhibit the K+ channel opening partially through synergistic interactions with Gli and BaCl2. DBD, ASR, and AR may be responsible for inhibiting [Ca2+]out, while ASR and AR can also inhibit [Ca2+]in.Conclusion: DBD can relax MCA with no effects on resting vessels. The mechanism may be related to ASR’s inhibition of KATP and Kir channels. Meanwhile, the inhibition of [Ca2+]out by DBD, ASR, and AR as well as the inhibition of [Ca2+]in by ASR and AR may contribute to dilate MCA.

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“…This indicates that CSS can exert effects similar to the antidepressant venlafaxine by regulating BDNF expression levels ( Zhang and Liu, 2020 ). Tropomyosin receptor kinase B (TrkB) is a specific receptor for BDNF, and it has been confirmed that activating BDNF-TrkB signaling can have an antidepressant effect ( Ma et al, 2020 ). Figure 4 After intervening with CSS in depression model rats, it was found that compared to the model group, rats in the CSS group exhibited significantly increased expression of BDNF and its receptor TrkB in the hippocampus, prefrontal cortex, and amygdala, suggesting that the mechanism through which CSS alleviates depressive states might be related to the increased expression of BDNF and its receptor TrkB in these brain regions ( Ying et al, 2011 ).…”

Section: The Antidepressant Mechanisms Of Cssmentioning

confidence: 99%

Potential antidepressant effects of Traditional Chinese botanical drug formula Chaihu-Shugan-San and its active ingredients

Guo,

Long,

Yao

et al. 2024

Front. Pharmacol.

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Background: Depression is a severe mental disorder that poses a significant threat to both the physical and mental wellbeing of individuals. Currently, there are various methods for treating depression, including traditional Chinese herbal formulations like Chaihu-Shugan-San (CSS), which have shown effective antidepressant effects in both clinical and animal research.Objective: This review aims to provide a comprehensive synthesis of evidence related to CSS, considering both preclinical and clinical studies, to uncover its potential multi-level, multi-pathway, and multi-target mechanisms for treating depression and identify its active ingredients.Methods: A thorough search was conducted in electronic databases, including PubMed, MEDLINE, Web of Science, Google Scholar, CNKI, and Wanfang, using keywords such as “Chaihu Shugan” and “depression” to retrieve relevant literature on CSS and its active ingredients. The review process adhered to the PRISMA guidelines.Results: This review consolidates the mechanisms underlying antidepressant effects of CSS and its active ingredients. It emphasizes its involvement in the regulation of monoaminergic neurotransmitter systems, synaptic plasticity, and the hypothalamic-pituitary-adrenal axis, among other aspects.Conclusion: CSS exerts a pivotal role in treating depression through various pathways, including the monoaminergic neurotransmitter system, the hypothalamic-pituitary-adrenal axis, synaptic plasticity, inflammation, brain-derived neurotrophic factor levels, and the brain-gut axis. This review facilitates a comprehensive understanding of the current state of CSS research, fostering an in-depth exploration of the etiological mechanisms of depression and the potential discovery of novel antidepressant drugs.

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TMEM16A-encoded anoctamin 1 inhibition contributes to chrysin-induced coronary relaxation

Cited by 5 publications

References 56 publications

Therapeutic potential of flavonoids used in traditional Chinese medicine – a comparative study of galangin, kaempferol, chrysin and fisetin

Therapeutic potential of flavonoids used in traditional Chinese medicine – a comparative study of galangin, kaempferol, chrysin and fisetin

Anticonstriction Effect of MCA in Rats by Danggui Buxue Decoction

Potential antidepressant effects of Traditional Chinese botanical drug formula Chaihu-Shugan-San and its active ingredients

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