TMJ osteoarthritis: A new approach to diagnosis

Rando, Carolyn; Waldron, Tony

doi:10.1002/ajpa.22039

Cited by 61 publications

(53 citation statements)

References 45 publications

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“…Osteophytes, referred to as bony spurs, are one of the radiographic hallmarks of TMJ degenerative joint disease and represent a late stage of the disease resulting from the host’s adaptive responses (Hunter and Kalathingal, 2013; Hussain et al, 2008). Compared to OA synovial joints in appendicular skeletal elements, osteophyte formation in TMJ OA is relatively rare; once developed however, the osteophytes can eventually compromise TMJ function (Hunter and Kalathingal, 2013; Rando and Waldron, 2012). …”

Section: Introductionmentioning

confidence: 99%

Osteophyte formation and matrix mineralization in a TMJ osteoarthritis mouse model are associated with ectopic hedgehog signaling

et al. 2016

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The temporomandibular joint (TMJ) is a diarthrodial joint that relies on lubricants for frictionless movement and long-term function. It remains unclear what temporal and causal relationships may exist between compromised lubrication and onset and progression of TMJ disease. Here we report that Proteoglycan 4 (Prg4)-null TMJs exhibit irreversible osteoarthritis-like changes over time and are linked to formation of ectopic mineralized tissues and osteophytes in articular disc, mandibular condyle and glenoid fossa. In the presumptive layer of mutant glenoid fossa’s articulating surface, numerous chondrogenic cells and/or chondrocytes emerged ectopically within the type I collagen-expressing cell population, underwent endochondral bone formation accompanied by enhanced Ihh expression, became entrapped into temporal bone mineralized matrix, and thereby elicited excessive chondroid bone formation. As the osteophytes grew, the roof of the glenoid fossa/eminence became significantly thicker and flatter, resulting in loss of its characteristic concave shape for accommodation of condyle and disc. Concurrently, the condyles became flatter and larger and exhibited ectopic bone along their neck, likely supporting the enlarged condylar heads. Articular discs lost their concave configuration, and ectopic cartilage developed and articulated with osteophytes. In glenoid fossa cells in culture, hedgehog signaling stimulated chondrocyte maturation and mineralization including alkaline phosphatase, while treatment with hedgehog inhibitor HhAntag prevented such maturation process. In sum, our data indicate that Prg4 is needed for TMJ integrity and long-term postnatal function. In its absence, progenitor cells near presumptive articular layer and disc undergo ectopic chondrogenesis and generate ectopic cartilage, possibly driven by aberrant activation of Hh signaling. The data suggest also that the Prg4-null mice represent a useful model to study TMJ osteoarthritis-like degeneration and clarify its pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Osteophyte formation and matrix mineralization in a TMJ osteoarthritis mouse model are associated with ectopic hedgehog signaling

et al. 2016

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“…Para relevar el estrés mecánico se observaron las superficies articulares en busca de indicios de degeneración articular -osteoartrosis-y alteración de las zonas de inserción muscular -cambios entésicos-(e.g. Jurmain et al 2012;Rando y Waldron 2012;Waldron 2009). Para el relevamiento de la osteoartrosis, se siguieron los criterios propuestos por Neves (1984) y Rodrigues Carvalho (2004.…”

Section: Materiales Y Métodosunclassified

Osteobiografía de dos individuos inhumados durante la Campaña del Desierto: el caso del sitio Chimpay (Argentina)

Serna

Prates

Luna

2017

Rev. Esp. Antropol. Am.

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RESUMENEl sitio Chimpay se encuentra en el valle medio del río Negro, pocos kilómetros al oeste de la isla de Choele Choel, en el centro-sur de la República Argentina. Se trata de un contexto de fines del siglo XIX conformado por el entierro doble de un hombre y una mujer adultos, asociados con un abundante y diverso acompañamien-to funerario de origen europeo e indígena, que sugiere que habrían gozado de cierta jerarquía y que el hombre habría ostentado un cargo militar en el ejército argentino. A fin de esclarecer este complejo ritual funerario, el presente trabajo parte de un enfoque osteobiográfico y busca avanzar en la identificación biológico-poblacional de los individuos e inferir condiciones generales de vida.Palabras clave: Siglo XIX, bioarqueología, osteobiografía. Osteobiography of Two Individuals Buried During the Desert Campaign:The Case of the Chimpay Site (Argentine) ABSTRACTThe Chimpay site is located in the Negro River middle valley, a few miles west from Choele Choel Island, in the south-center of Argentina. It is a late nineteenth century context that consists in a double burial of a man and a woman associated with a rich and diverse european and indigenous funeral offering, suggesting that they had a hierarchical social position and that the male would have had an Argentine military rank. In order to clarify this complex funeral ritual, the paper develops an osteobiographical approach and aims to give information about biological identification of the individuals and to infer their general living conditions.

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“…The right mandibular condyle was normal, but TMJ arthritis had developed in the left mandibular condyle with overall deformation (Figures 3a and 3b). It was of "Minimum Expression" under the Rando and Waldron classification [10]. The right mandibular fossa was normal, in contrast, in the left mandibular fossa, a new articular facet had formed accompanying inflammation and deformation of the mandibular condyle (Figures 4a and 4b), and it was evident that TMD and accompanying TMJ arthritis had developed.…”

Section: Case Descriptionmentioning

confidence: 99%

Prolonged Retention of Primary Teeth and TMD from the Archaeological Sample in the Edo Japanese

Fujita¹

2014

EJPM

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Prolonged retention of bilateral primary second molars was observed in ancient human skeletal remains excavated from temple ruins of the middle to late Edo period in Japan. Radiographs showed no sign of bilateral second premolars which appeared to be congenitally missing. Furthermore, there was inflammatory deformation of the left mandibular condyle, and pseudarthrosis at the articulation with the left mandibular fossa and a small hole on the articular surface were observed. The case of this study is a rare case in which prolonged retention of bilateral primary second molars was speculated to have resulted in malocclusion, which in turn might have led to temporomandibular disorder. In addition, this case is reported here because its information is thought to be applicable to clinical practice in modern dentistry.

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TMJ osteoarthritis: A new approach to diagnosis

Cited by 61 publications

References 45 publications

Osteophyte formation and matrix mineralization in a TMJ osteoarthritis mouse model are associated with ectopic hedgehog signaling

Osteophyte formation and matrix mineralization in a TMJ osteoarthritis mouse model are associated with ectopic hedgehog signaling

Osteobiografía de dos individuos inhumados durante la Campaña del Desierto: el caso del sitio Chimpay (Argentina)

Prolonged Retention of Primary Teeth and TMD from the Archaeological Sample in the Edo Japanese

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