TMPO-AS1 Regulates the Aggressiveness-Associated Traits of Nasopharyngeal Carcinoma Cells Through Sponging miR-320a

Xing, Baolin; Qiao, Xiaohong; Qiu, Yanhua; Li, Xin

doi:10.2147/cmar.s285113

Cited by 7 publications

(8 citation statements)

References 30 publications

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“…As a vital miRNA, miR-320a has been proved to have significant values in colorectal cancer (Zhang et al, 2021a), epithelial ovarian cancer (Zhang et al, 2021b), nasopharyngeal cancer (Xing et al, 2021), melanoma (Fu et al, 2020). More importantly, it has been reported that various miRNAs, such as miR-155 (Meng et al, 2021), miR-224-5p (Qin et al, 2021, miR-30b-5p (Zhang et al, 2021c), etc., are involved in the development of RCC by targeting different genes.…”

Section: Discussionmentioning

confidence: 99%

HIF-1α Induces HECTD2 Up-Regulation and Aggravates the Malignant Progression of Renal Cell Cancer via Repressing miR-320a

Shen

Yao

et al. 2021

Front. Cell Dev. Biol.

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Renal cell carcinoma (RCC) is a frequent malignancy of the urinary system. It has been found that hypoxia mediates the malignant evolvement of RCC. Here, we probe the impact and potential mechanism of HECT domain E3 ubiquitin-protein ligase 2 (HECTD2) and HIF-1α on regulating RCC evolvement. RCC tissues and adjacent normal tissues were collected, and the association between the expression profiles of HECTD2 and HIF-1α and the clinicopathological features was analyzed. Additionally, we constructed HECTD2/HIF-1α overexpression and knockdown models in RCC cell lines to ascertain the impacts of HECTD2 and HIF-1α on RCC cell proliferation, apoptosis, migration, and growth in vivo. We applied bioinformatics to predict the upstream miRNA targets of HECTD2. Meanwhile, RNA immunoprecipitation (RIP), and the dual-luciferase reporter assays were employed to clarify the targeting association between HECTD2 and miR-320a. The effect of miR-320a on HECTD2-mediated RCC progression was investigated. The results suggested that both HIF-1α and HECTD2 were up-regulated in RCC (compared with adjacent non-tumor tissues), and they had positive relationship. Moreover, higher level of HECTD2 and HIF-1α is associated with poorer overall survival of RCC patients. HECTD2 overexpression heightened RCC cell proliferation and migration, and weakened cell apoptosis. On the other hand, the malignant phenotypes of RCC cells were signally impeded by HECTD2 or HIF-1α knockdown. Moreover, miR-320a targeted the 3′-untranslated region of HECTD2 and suppressed HECTD2 expression. The rescue experiments showed that miR-320a restrained HECTD2-mediated malignant progression in RCC, while up-regulation of HIF-1α hampered miR-320a expression. Collectively, HIF-1α mediated HECTD2 up-regulation and aggravated RCC progression by attenuating miR-320a.

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Section: Discussionmentioning

confidence: 99%

HIF-1α Induces HECTD2 Up-Regulation and Aggravates the Malignant Progression of Renal Cell Cancer via Repressing miR-320a

Shen

Yao

et al. 2021

Front. Cell Dev. Biol.

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“…It should be noted that HNSCC is a type of immunosuppressive disease [ 43 ]. Despite the effectiveness of targeted therapies and immunotherapy agents in the context of HNSCC, not all patients respond to such treatments and the development of resistance is almost universal after a period of time.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, in clinical practice, ICI therapy does not appear to improve the survival of HNSCC patients. Instead, precision medicine approaches that seek to individualize therapy through the use of predictive biomarkers and stratification strategies have been the key to improve the therapeutic outcomes of HNSCC patients [ 32 , 43 ]. Hence, it is essential to develop sensitive predictive biomarkers, essential for the deeper understanding of the heterogeneity and complexity of the tumor immune microenvironment; only through this approach can we finally improve the efficacy of tumor immunotherapy.…”

Section: Discussionmentioning

confidence: 99%

A novel immune-related long non-coding RNA signature improves the prognosis prediction in the context of head and neck squamous cell carcinoma

et al. 2021

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The tumor immune microenvironment plays an important role in head and neck squamous cell carcinoma (HNSCC). Reliable prognostic signatures able to accurately predict the immune landscape and survival rate of HNSCC patients are crucial to ensure an individualized/effective treatment. Here, we used HNSCC transcriptomic and clinical data retrieved from The Cancer Genome Atlas and identified differentially expressed immune-related long non-coding RNAs (DEirlncRNAs). DEirlncRNA pairs were recognized using univariate analysis. Cox and Lasso regression analyses were used to determine the association between DEirlncRNA pairs and the patients' overall survival and build the prediction model. Receiver operating characteristic curves and Kaplan-Meier survival curves were used to validate the prediction model. We then reevaluated the model based on the clinical factors, tumor-infiltrating immune cells, chemotherapeutic efficacy, and immunosuppression biomarkers. We built a risk score model based on 18 DEirlncRNA pairs, closely related to the overall survival of patients (hazard ratio: 1.376; 95% confidence interval: 1.302-1.453; P < 0.0001). Compared with two recently published lncRNA signatures, our DEirlncRNA pair signature had a higher area under the curve, indicating better prognostic performance. Additionally, the signature score positively correlated with aggressive HNSCC outcomes (low immunity score, significantly reduced CD8 + T cell infiltration, and low expression of immunosuppression biomarkers). However, high-risk patients might have high chemosensitivity. Overall, the lncRNAs signature established here shows promising clinical prediction and the effective disclosure of the tumor immune microenvironment in HNSCC patients; therefore, such signature might help distinguish patients that could benefit from immunotherapy.

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“…Extremely rare cases have been also linked to the human immunodeficiency virus (HIV) infection; one case presented the patient as being co-infected with EBV. Much as the Koebner phenomenon in skin disorders, NPC develops in a prior set environment, with certain characteristics which support malignant growth (5,(10)(11)(12)(13)(14)(15).…”

Section: Epidemiology and Etiologymentioning

confidence: 99%

Nasopharyngeal carcinoma: A new synthesis of literature data (Review)

et al. 2021

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Nasopharyngeal carcinoma (NPC) is an epithelial tumor, which develops most frequently from the lateral pharyngeal recess and holds some complex epidemiological characteristics. Its unusual race and geographic distribution suggests that not only the environmental factors are a contributing factor to the development of this rare cancer type, but also the genetic traits play an important role, along with nitrosamine-containing food consumption and Epstein-Barr virus infection. The signs and symptoms which a patient can present and suffer from are various and include nasal, otic, neurological as well as general ones; the way this tumor manifests being dependent on the stage of the tumor. The therapeutic management applicable in NPC needs to be established according to the case of the patient and include radiotherapy, chemotherapy, surgery, immune therapy, targeted therapy or combined treatment. The main objective of the treatment is local and regional tumor control; relapse is an important factor for future development of distant metastases. New therapeutic concepts are always sought of, current research focusing on precision medicine, meaning systemic treatment with a personalized radiotherapy approach according to the characteristics of the tumor.

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TMPO-AS1 Regulates the Aggressiveness-Associated Traits of Nasopharyngeal Carcinoma Cells Through Sponging miR-320a

Cited by 7 publications

References 30 publications

HIF-1α Induces HECTD2 Up-Regulation and Aggravates the Malignant Progression of Renal Cell Cancer via Repressing miR-320a

HIF-1α Induces HECTD2 Up-Regulation and Aggravates the Malignant Progression of Renal Cell Cancer via Repressing miR-320a

A novel immune-related long non-coding RNA signature improves the prognosis prediction in the context of head and neck squamous cell carcinoma

Nasopharyngeal carcinoma: A new synthesis of literature data (Review)

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