TMS and drugs revisited 2014

Ziemann, Ulf; Reis, Janine; Schwenkreis, Peter; Rosanova, Mario; Strafella, Antonio P.; Badawy, Radwa A.B.; Müller‐Dahlhaus, Florian

doi:10.1016/j.clinph.2014.08.028

Cited by 567 publications

(673 citation statements)

References 337 publications

(417 reference statements)

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“…On the other hand, only modest alterations in SICI and ICF were observed in P1, P2 and P4. SICI is thought to reflect short-lasting postsynaptic inhibition, mediated by the g-aminobutyric acid (GABA) A receptor at the local interneuron level, while ICF is thought to represent net facilitation of neuronal excitability, most likely mediated by glutamatergic N-methyl-D-aspartate (NMDA) receptors (Ziemann et al 2015). Our findings therefore suggest mild impairments in GABA A receptormediated and NMDA receptor-mediated neurotransmission in patients with NPC1 gene mutations.…”

Section: Discussionmentioning

confidence: 76%

Preliminary Results on Long-Term Potentiation-Like Cortical Plasticity and Cholinergic Dysfunction After Miglustat Treatment in Niemann-Pick Disease Type C

Benussi

Cotelli²,

Cosseddu

et al. 2017

JIMD Reports

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Niemann-Pick disease type C (NPC) is a rare autosomal recessive lysosomal storage disorder, which manifests clinically with a wide range of neurological signs and symptoms. We assessed multiple neurological, neuropsychological and neurophysiological biomarkers using a transcranial magnetic stimulation (TMS) multi-paradigm approach in two patients with NPC carrying a homozygous mutation in the NPC1 gene, and in two heterozygous family members.We assessed short-interval intracortical inhibition (SICI), intracortical facilitation (ICF), long-interval intracortical inhibition (LICI), short-latency afferent inhibition (SAI) and long-term potentiation (LTP)-like cortical plasticity with a paired associative stimulation (PAS) protocol.Baseline SAI and LTP-like plasticity were impaired in both patients with NPC and in the symptomatic heterozygous NPC1 gene mutation carrier. Only a limited decrease in SICI and ICF was observed, while LICI was within normal range in all subjects at baseline. After 12 months of treatment with miglustat, a considerable improvement in SAI and LTP-like plasticity was observed in both patients with NPC. In conclusion, these biomarkers could help to confirm the diagnosis of NPC, and may give an indication of prognostic outcomes in pharmacological trials.

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Section: Discussionmentioning

confidence: 76%

Preliminary Results on Long-Term Potentiation-Like Cortical Plasticity and Cholinergic Dysfunction After Miglustat Treatment in Niemann-Pick Disease Type C

Benussi

Cotelli²,

Cosseddu

et al. 2017

JIMD Reports

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“…We used paired-pulse TMS to assess GABAA-mediated short-interval intracortical inhibition (SICI) and GABAB-mediated longinterval intracortical inhibition (LICI), which provides a more robust assessment of M1 GABAergic inhibition compared with previous studies involving the SP [28]. As previous findings suggest that lengthening contractions are associated with disinhibition of contralateral M1 [7,8,25], we expected that lengthening movements would also be associated with a reduction in SICI and LICI.…”

Section: Age-and Movement-related Changes In Intracortical Inhibitionmentioning

confidence: 99%

Intracortical Inhibition Assessed with Paired-Pulse Transcranial Magnetic Stimulation is Modulated during Shortening and Lengthening Contractions in Young and Old Adults

Opie

Semmler

2016

Brain Stimulation

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In all cases accepted manuscripts should: link to the formal publication via its DOI  bear a CC-BY-NC-ND license -this is easy to do, click here to find out how  if aggregated with other manuscripts, for example in a repository or other site, be shared in alignment with our hosting policy  not be added to or enhanced in any way to appear more like, or to substitute for, the published journal article Embargo 1935-861X Brain Stimulation 129 May 2017 Age-and movement-related changes in intracortical inhibitionPage 2 AbstractBackground: The modulation of intracortical inhibition is thought to be impaired in older

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“…This could be a consequence of their drug treatment which in most cases included scopolamine, an anticholinergic. It is known that these drugs can interfere with synaptic plasticity; see recent review by Ziemann et al [29].…”

Section: Discussionmentioning

confidence: 99%

Effect of Repetitive Transcranial Magnetic Stimulation on Malignant Visceral Pain

Khedr¹,

Mostafa²,

Kotb³

et al. 2015

Neuroenterology

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Background and objectives. To assess the efficacy of 10 sessions (once daily for 10 days) of repetitive transcranial magnetic stimulation (rTMS) on primary motor cortex (M1) in patients suffering from malignant visceral pain. Materials and methods. Thirty four patients were included in the study. They were divided randomly into two groups (17 patients for each, using closed envelopes): real rTMS (20 Hz, 10 trains with intertrain interval of 30 s with total pulses 2,000, intensity 80% of motor threshold) and sham rTMS (coil elevated and angled away from the head). Stimulation was applied over M1 every day for ten consecutive days. Patients were evaluated using a verbal descriptor scale (VDS), visual analog scale (VAS), and Hamilton rating scale for depression (HAM-D) at baseline; after the 1st, 5th, and 10th sessions; and then at 15 days and one month later after the end of the treatment sessions. Serum human dynorphin (Dyn) was measured at baseline, and after the 5th and 10th sessions. Results. Fifteen patients from each group completed the study. There was no significant difference between real and sham groups in the duration of illness, or any rating scales at baseline. Compared with the sham group, the VAS/VDS scores decreased more in patients who received real rTMS over the course of the treatment and at 15 days follow-up than in those who received sham stimulation. Scores were the same at one month follow-up. There were no significant changes in serum human Dyn in either group. Conclusion. The results confirm that 10 sessions of rTMS over the M1 can induce pain relief in malignant visceral pain for at least 15 days but the effect is not maintained at one month.

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TMS and drugs revisited 2014

Cited by 567 publications

References 337 publications

Preliminary Results on Long-Term Potentiation-Like Cortical Plasticity and Cholinergic Dysfunction After Miglustat Treatment in Niemann-Pick Disease Type C

Preliminary Results on Long-Term Potentiation-Like Cortical Plasticity and Cholinergic Dysfunction After Miglustat Treatment in Niemann-Pick Disease Type C

Intracortical Inhibition Assessed with Paired-Pulse Transcranial Magnetic Stimulation is Modulated during Shortening and Lengthening Contractions in Young and Old Adults

Effect of Repetitive Transcranial Magnetic Stimulation on Malignant Visceral Pain

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