TMS and neocortical neurons: an integrative review on the micro-macro connection in neuroplasticity

Tian, Dongting; Izumi, Shin-ichi

doi:10.11336/jjcrs.14.1

Cited by 2 publications

(4 citation statements)

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“…Although the evidence regarding SICF modulation by rTMS is highly inconsistent ( Fitzgerald et al, 2006 ), we found it intriguing that SICF-I3 was suppressed by AP-iTMS. As the ISI of SICF-I3 is approximately 4.5 ms, which is approximately ~3 synapse conduction time ( Ziemann, 2020 ; Tian and Izumi, 2022b ; Tian and Izumi, 2023 ), the results suggest that the facilitation from paired-pulse SICF-I3 might be generated from longer neuron chains with multiple synapses, with the neurons on the chain bearing more inhibition from local INs ( Peurala et al, 2008 ). This effect can become greater if the I3 circuitry is specifically targeted by AP-iTMS.…”

Section: Discussionmentioning

confidence: 92%

“…For LICF, empirical evidence regarding its mechanisms is still lacking. However, as proposed in our previous model LICF might be related to the timing-dependent inhibition-excitation shift of chandelier cells (ChCs, a subtype of cortical INs) on the postsynaptic neurons (Woodruff et al, 2011;Tian and Izumi, 2022b;Tian and Izumi, 2023). For INs, based on quantitative proportion (Rudy et al, 2011;Bakken et al, 2021), two main IN subtypes related to intracortical inhibition are included in the model, being the basket cells (BCs) and ChCs.…”

Section: Itms Neurocytological Mechanism Modelmentioning

confidence: 95%

“…Inhibition and facilitation in the human motor cortex have been examined extensively using transcranial magnetic stimulation (TMS) ( Valero-Cabré et al, 2017 ; Tian and Izumi, 2023 ). In epidural recordings, the TMS-evoked corticospinal descending volleys are named in arrival order as the direct wave (D-wave, with the shortest latency, reflecting the direct excitation of cortical pyramidal tract neurons, PTNs) and the indirect waves (I-waves, reflecting the indirect excitation impinging on PTNs from the non-PTN neuron circuits) ( Patton and Amassian, 1954 ; Di Lazzaro et al, 2012 ; Di Lazzaro and Rothwell, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Different effects of I-wave periodicity repetitive TMS on motor cortex interhemispheric interaction

Tian

Izumi

2023

Front. Neurosci.

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BackgroundActivity of the neural circuits in the human motor cortex can be probed using transcranial magnetic stimulation (TMS). Changing TMS-induced current direction recruits different cortical neural circuits. I-wave periodicity repetitive TMS (iTMS) substantially modulates motor cortex excitability through neural plasticity, yet its effect on interhemispheric interaction remains unclear.ObjectiveTo explore the modulation of interhemispheric interaction by iTMS applied in different current directions.Materials and MethodsTwenty right-handed healthy young volunteers (aged 27.5 ± 5.0 years) participated in this study with three visits. On each visit, iTMS in posterior–anterior/anterior–posterior direction (PA-/AP-iTMS) or sham-iTMS was applied to the right hemisphere, with corticospinal excitability and intracortical facilitation of the non-stimulated left hemisphere evaluated at four timepoints. Ipsilateral silent period was also measured at each timepoint probing interhemispheric inhibition (IHI).ResultsPA- and AP-iTMS potentiated cortical excitability concurrently in the stimulated right hemisphere. Corticospinal excitability of the non-stimulated left hemisphere increased 10 min after both PA- and AP-iTMS intervention, with a decrease in short-interval intracortical facilitation (SICF) observed in AP-iTMS only. Immediately after the intervention, PA-iTMS tilted the IHI balance toward inhibiting the non-stimulated hemisphere, while AP-iTMS shifted the balance toward the opposite direction.ConclusionsOur findings provide systematic evidence on the plastic modulation of interhemispheric interaction by PA- and AP-iTMS. We show that iTMS induces an interhemispheric facilitatory effect, and that PA- and AP-iTMS differs in modulating interhemispheric inhibition.

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Section: Discussionmentioning

confidence: 92%

Section: Itms Neurocytological Mechanism Modelmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Different effects of I-wave periodicity repetitive TMS on motor cortex interhemispheric interaction

Tian

Izumi

2023

Front. Neurosci.

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“…D. Tian and S.I. Izumi (17) conducted studies of neuroplasticity and determined the main aspects of microand macrocommunication. The main properties of neural networks were determined, but during the research little attention was paid to the recovery processes in diseases and their importance for medicine, especially in severe cases.…”

Section: Implications For Healing and Resiliencementioning

confidence: 99%

Self-healing and healing of the body with the help of neural connections of the brain

Spytska

2023

Innovaciencia

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Introduction: The need to maintain people’s health and extend the life span of the body stimulates finding new methods of maintaining it. Today, this question is quite important, because the consequences of serious diseases cannot always be corrected, but their formation can be prevented. Therefore, the need to study the issue of self-regeneration of the body is urgent. The purpose of the article is to analyse the main methods and aspects of neuroplasticity support, as well as to highlight the main principles of the formation of new synaptic connections. Materials and Methods: Methods of analysis, generalization, systematization, comparison, and survey were used to determine the features of self-regeneration of the organism through the formation of new neural networks. Results and Discussion: The article analysed ways of forming neural connections that help and methods of improvement. It was determined which factors of the external environment affect the self-recovery process and how to ensure the reduction of the influence of harmful factors. The data obtained during the survey of people were analysed and the main differences in the way of life, as well as its influence on the properties of the brain, were determined. The article identified the most effective methods of self-recovery of the body and the trend of their popularity among the population. The obtained data were compared and the main aspects of the effectiveness of the method of healing the body with the help of neural connections were summarized. During the study, the effectiveness of popular methods of obtaining a positive result of body recovery was analysed. The influence of psycho-emotional factors on the general condition of a person was determined. Conclusions: The results of the study can help psychologists and therapists formulate special programs to avoid brain overload.

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TMS and neocortical neurons: an integrative review on the micro-macro connection in neuroplasticity

Cited by 2 publications

References 53 publications

Different effects of I-wave periodicity repetitive TMS on motor cortex interhemispheric interaction

Different effects of I-wave periodicity repetitive TMS on motor cortex interhemispheric interaction

Self-healing and healing of the body with the help of neural connections of the brain

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