TMT-based quantitative proteomics revealed protective efficacy of Icariside II against airway inflammation and remodeling via inhibiting LAMP2, CTSD and CTSS expression in OVA-induced chronic asthma mice

Zhou, Yaolong; Huang, Xi; Yu, Hang; Shi, Hongcheng; Chen, Mengmeng; Song, Jingrong; Tang, Weifeng; Teng, Fangzhou; Li, Congcong; Liu, Yi; Zhu, Xueyi; Wang, Na; Wei, Ying; Wuniqiemu, Tulake; Dong, Jingcheng

doi:10.1016/j.phymed.2023.154941

Cited by 12 publications

(4 citation statements)

References 75 publications

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“…ASM mass is estimated to increase 50 %–200 % in patients with non-fatal asthma and 200 %–400 % in patients with fatal asthma [ 44 ]. Airway remodeling is present in many obstructive pulmonary diseases, and previous studies suggest that airway remodeling is an event triggered by chronic airway inflammation, but recent studies suggest that airway remodeling may emerge as an initial event, even before triggering any respiratory symptoms and inflammation process [ 1 , 45 ]. Therefore, there are still many mysteries about airway remodeling in obstructive pulmonary disease, and there is currently a lack of effective interventions for airway remodeling in clinical practice, which is one of the most challenging problems in treating respiratory diseases and is the goal of future treatment [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Airway remodeling refers to structural and functional changes in airway tissue due to repeated chronic inflammatory stimuli and incomplete repair [ 1 ]. The pathological changes include goblet cell metaplasia, extracellular matrix protein deposition and fibrosis, overexpression of angiogenic factors, and proliferation and/or hypertrophy of airway smooth muscle cells [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Research trends on airway remodeling: A bibliometrics analysis

Liu,

Wang,

Chen

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Research trends on airway remodeling: A bibliometrics analysis

Liu,

Wang,

Chen

et al. 2024

Heliyon

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“…Three sections of each colon were evaluated for each score. To measure the number of goblet cells by PAS staining, the percentage of positively stained cells in the area of interest (AOI) was calculated using ImageJ software (Version 1.53k) [33].…”

Section: Histological Analysismentioning

confidence: 99%

Anti-Inflammatory Effects of Artemisia argyi H. Fermented by Lactobacillus plantarum in the LPS-Induced RAW 264.7 Cells and DSS-Induced Colitis Model

Lee,

Kim,

Choi

et al. 2024

Foods

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Ulcerative colitis is a chronic inflammatory disease caused by abnormal immune responses in the intestinal mucosa and gut microorganisms. Unlike other mugworts, Artemisia argyi H. (A. argyi H.) enhances antioxidant, anti-inflammatory, and anticancer effects, but the improvement effects against gut inflammation have not yet been reported. Therefore, this study aimed to confirm the alleviation of the inflammatory state in the gut by A. argyi H. fermented with Lactobacillus plantarum (FAA), using lipopolysaccharide (LPS)-induced RAW 264.7 cells and dextran sulfate sodium (DSS)-induced colitis models. In vitro, FAA (10, 50, 100, and 200 μg/mL) was pretreated into RAW 264.7 cells, followed with LPS (100 ng/mL), which induced the cell damage. Meanwhile, in vivo, FAA (100, 200 mg/kg/day) was orally administered into 6-week-old C57BL/6N mice for 3 weeks. During the last week of FAA administration, 2.5% DSS was used to induce colitis. The results showed that FAA reduced the production of nitric oxide (p < 0.0001), tumor necrosis factor (TNF)-α, interleukin (IL)-6 (p < 0.0001), and IL-1β (p < 0.0001) in the LPS-induced RAW 264.7 cells. Moreover, in the DSS-induced colitis model, FAA alleviated clinical symptoms (p < 0.001), inhibited the inflammatory state by reducing the production of TNF-α (p < 0.0001) and interferon-γ in intestinal immune cells (p < 0.0001), and strengthened the intestinal barrier by increasing the number of goblet cells (p < 0.0001). Furthermore, the anti-inflammatory effects were confirmed by the alleviation of histological damage (p < 0.001) and down-regulation of the expression of inflammatory proteins (TLR4, p < 0.0001; MyD88, p < 0.0001; Cox-2, p < 0.0001). These results suggest the potential of FAA as a dietary ingredient for preventing inflammation in the gut.

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“…Current studies have shown that baohuoside I exhibits promising anti-tumor effects on lung cancer cells [41], melanoma cells [42], breast cancer cells [43], prostate cancer cells [44], and osteosarcoma cells [45]. Furthermore, baohuoside I has shown its potential application in type 2 diabetes treatment [46], neuroprotection [47], and asthma inhibition [48].…”

Section: Baohuoside I and Its Pharmaceutical Effectsmentioning

confidence: 99%

Advancements in the Biotransformation and Biosynthesis of the Primary Active Flavonoids Derived from Epimedium

Zhang,

Tang,

Wen

et al. 2023

Molecules

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Epimedium is a classical Chinese herbal medicine, which has been used extensively to treat various diseases, such as sexual dysfunction, osteoporosis, cancer, rheumatoid arthritis, and brain diseases. Flavonoids, such as icariin, baohuoside I, icaritin, and epimedin C, are the main active ingredients with diverse pharmacological activities. Currently, most Epimedium flavonoids are extracted from Epimedium plants, but this method cannot meet the increasing market demand. Biotransformation strategies promised huge potential for increasing the contents of high-value Epimedium flavonoids, which would promote the full use of the Epimedium herb. Complete biosynthesis of major Epimedium flavonoids by microbial cell factories would enable industrial-scale production of Epimedium flavonoids. This review summarizes the structures, pharmacological activities, and biosynthesis pathways in the Epimedium plant, as well as the extraction methods of major Epimedium flavonoids, and advancements in the biotransformation and complete microbial synthesis of Epimedium flavonoids, which would provide valuable insights for future studies on Epimedium herb usage and the production of Epimedium flavonoids.

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TMT-based quantitative proteomics revealed protective efficacy of Icariside II against airway inflammation and remodeling via inhibiting LAMP2, CTSD and CTSS expression in OVA-induced chronic asthma mice

Cited by 12 publications

References 75 publications

Research trends on airway remodeling: A bibliometrics analysis

Research trends on airway remodeling: A bibliometrics analysis

Anti-Inflammatory Effects of Artemisia argyi H. Fermented by Lactobacillus plantarum in the LPS-Induced RAW 264.7 Cells and DSS-Induced Colitis Model

Advancements in the Biotransformation and Biosynthesis of the Primary Active Flavonoids Derived from Epimedium

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