2023
DOI: 10.21203/rs.3.rs-3394919/v1
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TNF-a-induced laminin-332 promotes an atherogenic endothelial phenotype

Assim Hayderi,
Mulugeta Melkie Zegeye,
Sare Meydan
et al.

Abstract: Background:Laminins are key components of the basement membranes separating endothelial cells from the underlying tissues. They form complex networks of fibers within the basement membrane to provide structural support and regulate the behavior and function of surrounding cells. In mammals, the products of the five alpha, four beta and three gamma laminin genes are combined to generate 16-18 laminin isoforms, which under physiological circumstances confer some tissue specificity, with alpha 4- and alpha 5-cont… Show more

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