TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression

Şahin, Tuğçe Demirtaş; Karson, Ayşe; Balcı, Fuat; Yazır, Yusufhan; Bayramgürler, Dilek; Utkan, Tijen

doi:10.1016/j.bbr.2015.05.062

Cited by 103 publications

(51 citation statements)

References 61 publications

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“…Consistent with this hypothesis, MS exposure increases adolescent PFC levels of cyclooxygenase‐2, which is an enzyme expressed during pro‐inflammatory activity and is a contributor to oxidative stress; blocking cyclooxygenase‐2 activity during early adolescence protects against PVB loss after MS (Brenhouse & Andersen, ). Moreover, stress has been repeatedly reported to yield oxidative damage in the PFC (Tagliari et al, ; Zlatkovic et al, ) and to provoke a pro‐inflammatory phenotype in rodent models of depression and cognitive impairment (Sahin et al, ; Wieck, Andersen, & Brenhouse, ). Therefore, we hypothesized that MS leads to a pro‐inflammatory phenotype and increased oxidative stress in the PFC with subsequent loss of PFC PVB and working memory deficits.…”

Section: Introductionmentioning

confidence: 99%

Effects of early adolescent environmental enrichment on cognitive dysfunction, prefrontal cortex development, and inflammatory cytokines after early life stress

Prado

Narahari

Holland

et al. 2015

Developmental Psychobiology

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Early postnatal stress such as maternal separation causes cognitive dysfunction later in life, including working memory deficits that are largely mediated by the prefrontal cortex. Maternal separation in male rats also yields a loss of parvalbumin-containing prefrontal cortex interneurons in adolescence, which may occur via inflammatory or oxidative stress mechanisms. Environmental enrichment can prevent several effects of maternal separation; however, effects of enrichment on prefrontal cortex development are not well understood. Here, we report that enrichment prevented cognitive dysfunction in maternally separated males and females, and prevented elevated circulating pro-inflammatory cytokines that was evident in maternally separated males, but not females. However, enrichment did not prevent parvalbumin loss or adolescent measures of oxidative stress. Significant correlations indicated that adolescents with higher oxidative damage and less prefrontal cortex parvalbumin in adolescence committed more errors on the win-shift task; therefore, maternal separation may affect cognitive dysfunction via aberrant interneuron development. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 58: 482-491, 2016.

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Section: Introductionmentioning

confidence: 99%

Effects of early adolescent environmental enrichment on cognitive dysfunction, prefrontal cortex development, and inflammatory cytokines after early life stress

Prado

Narahari

Holland

et al. 2015

Developmental Psychobiology

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“…In humans, brain BDNF levels have been found to be reduced in postmortem samples from depressed patients, and antidepressant therapies restored brain BDNF level to the normal range (Matrisciano et al, 2009). As well as clinical studies, it has also been shown that BDNF expression was decreased in the hippocampus and prefrontal cortex of depressive animals, which could be reversed by long term antidepressant treatment (Mendez-David et al, 2015;Sahin et al, 2015). Therefore, when we examined the effects of red wine extract on the corticosterone-mediated decrease in BDNF protein levels, the results of long-term red wine extract treatment reversing the reduction suggested that the behavioral improvement in the model may be concurrent with increased BDNF levels.…”

Section: Discussionmentioning

confidence: 90%

Antidepressant-like activity of red wine phenolic extracts in repeated corticosterone-induced depression mice via BDNF/TrkB/CREB signaling pathway

et al. 2016

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Abstract. The aim of this study was to investigate the antidepressant-like effect of red wine phenolic extracts in mouse model exposed to exogenous corticosterone. The results showed that 3-week corticosterone injections caused depression-like behavior in mice, as indicated by the significant decrease in sucrose consumption and increase immobility time in the forced swim test. Red wine phenolic extracts treatment significantly reduced serum corticosterone levels. Moreover, it was found that red wine phenolic extract increased the brain-derived neurotrophic factor protein (BNDF) and Tropomyosin-related kinase B (TrkB) phosphorylation and cAMP-responsive element binding protein (CREB) phosphorylation levels in the hippocampus and prefrontal cortex. However, K252a, an inhibitor of TrkB, completely abolished those antidepressant-like effects. These results suggested that the red wine phenolic extracts produce an antidepressant-like effect in corticosterone-treated mice, at least in part, which is possibly mediated by modulating hypothalamic-pituitary-adrenal (HPA) axis, BDNF, TrkB and CREB phosphorylation levels in the brain region of mice.

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“…Taken together, HFD and CMS appear to act synergistically to cause depression-like symptoms. Indeed, multiple studies have suggested that CMS causes depression-like behaviors, such as alterations of affective processes and impairment of cognitive performance (35).…”

Section: Discussionmentioning

confidence: 99%

Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress

Yang

Qian

2017

Experimental and Therapeutic Medicine

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Abstract.A high-fat diet (HFD) is highly correlated to obesity, metabolic diseases and certain behavioral changes. However, the effects of post-weaning HFD in rats during puberty and the role of the hypothalamic-pituitary-adrenal (HPA) axis in this process have remained elusive. The present study hypothesized that the HPA axis mediates the behavioral alterations induced by a post-weaning HFD. To investigate this, female rats were divided into two groups, one of which was fed a HFD from postnatal weeks (PWs) 4-12, while the other group received standard chow. Rats in each group were then subdivided into two subgroups each, and from PW 9-12, animals from one of the two subgroups were subjected to chronic mild stress (CMS), while the other subgroup received no stress. At PW 12, the body weight of rats receiving a HFD but no DMS was significantly higher than that in the control group. The frequency of crossing and rearing in the open field test and the time in the center of the Y-maze were decreased following CMS. Total time to escape was decreased in rats receiving HFD and after CMS. The serum levels of adrenocorticotropic hormone and corticosterone were increased in rats receiving an HFD and after CMS, and the mRNA levels of corticotropin-releasing hormone and arginine vasopressin in the hypothalamus were increased in the HFD + CMS group compared to that in the control group. The mRNA expression of glucocorticoid receptor (GR) in the hippocampi of rats in the HFD + CMS group was significantly decreased and the mineralocorticoid receptor/GR ratio was increased compared to that in the groups receiving either CMS or a HFD. In conclusion, these results indicated that female rats fed a post-weaning HFD showed HPA axis hypersensitivity under CMS, which may mediate behavioral alterations.

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TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression

Cited by 103 publications

References 61 publications

Effects of early adolescent environmental enrichment on cognitive dysfunction, prefrontal cortex development, and inflammatory cytokines after early life stress

Effects of early adolescent environmental enrichment on cognitive dysfunction, prefrontal cortex development, and inflammatory cytokines after early life stress

Antidepressant-like activity of red wine phenolic extracts in repeated corticosterone-induced depression mice via BDNF/TrkB/CREB signaling pathway

Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress

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