TNF-&amp;alpha; in the cardiovascular system: from physiology to therapy

Urschel, Katharina; Cicha, Iwona

doi:10.2147/ijicmr.s64894

Cited by 70 publications

(74 citation statements)

References 205 publications

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“…Binding of TNF-α to TNFR1 can trigger inflammatory signaling pathways. This binding activates the transcription factors nuclear factor kappa B (NF-κB) and c-Jun/ATF-2 to enhance recruitment of leukocytes including monocytes, B cells and T cells (13,37). NF-κB is a transcription factor involved in synthesis of the pro-inflammatory cytokine TNF-α.…”

Section: Discussionmentioning

confidence: 99%

“…Macrophages and dendritic cells that express Toll-like receptors that bind oxLDL scavenger receptors initiate an inflammatory signaling pathway by secreting pro-inflammatory cytokines such as tumour necrosis factor α (TNF-α) (12). The activation of inflammatory signaling pathways induces endothelial cells and smooth muscle cells to express adhesion molecules, chemoattractants, and growth factors and results in migration of leukocytes and smooth muscle cells in inflammatory blood vessel walls (10,13).…”

Section: Introductionmentioning

confidence: 99%

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Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Arifah

Atho'illah

Lukiati

et al. 2020

MJMS

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Introduction: High fat diet (HFD) can cause lipid accumulation and contribute to various metabolic disorders. Single clove garlic oil (SCGO) has advantages over regular garlic due to its higher amounts of organosulfide compounds in particular. This study aimed to determine the ability of SCGO extract to ameliorate hepatic steatosis and improve oxidative status by modulating expression of tumour necrosis factor α and superoxide dismutase in mice fed a HFD.Methods: Twenty-four adult male Balb/C mice were divided into six groups: i) normal diet; ii) positive control diet; iii) negative control diet; and iv) HFD with SCGO at 12.5 mg/kg body weight (mg/kg BW); v) HFD with SCGO at 25 mg/kg BW, vi) HFD with SCGO at 50 mg/kg BW. Liver weight and morphology, spleen weight, serum levels of superoxide dismutase (SOD) and tumour necrosis factor α (TNF-α), TNF-α expression in the aorta and lipid profiles were assessed at the end of the experimental period.Results: SCGO treatment was associated with significant decreases in liver and spleen weight as well as amelioration of hepatic steatosis. SCGO treatment also decreased TNF-α levels and expression. Serum levels of SOD in the SCGO groups were significantly increased compared with the negative control group. Lipid profiles were improved in the SCGO treatment groups compared with the negative control group.Conclusion: SCGO as an herbal medicine could be an effective treatment for degenerative disorders caused by HFD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Arifah

Atho'illah

Lukiati

et al. 2020

MJMS

View full text Add to dashboard Cite

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“…TNF-α was declared, in 1975, as a circulating antitumorigenic cytokine produced from such immune cells as activated macrophages and lymphocytes. 8,9 On binding with receptors, it controls the expression of inflammation and injury. It is a transmembrane protein with 212 amino acid sequence, existing in a homotrimer stable form that binds with two receptors, TNFR1 and TNFR2.…”

Section: Introductionmentioning

confidence: 99%

Clinical Benefits of Switching from Original Infliximab to its Biosimilar (CT-P13) as a Potential TNF-α Inhibitor

Kumari¹,

Prasad²,

Kumar³

et al. 2020

Journal of Exploratory Research in Pharmacology

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Tumor necrosis factor-alpha (TNF-α) is implicated in the process of various autoimmune and inflammatory diseases through binding to its receptor, the tumor necrosis factor receptor. Nowadays, monoclonal anti-TNF-α antibody is used for the treatment of these diseases because it can neutralize TNF-α to block the relevant signaling responsible for the pathogenesis of these diseases. Currently, such antibody-based therapies have been demonstrated to be effective in controlling rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis. Infliximab is the first monoclonal antibody for the treatment of rheumatoid arthritis and has been approved for the intervention of other autoimmune and inflammatory diseases in the clinic. Although infliximab is considered highly efficacious, more so than common medications such as methotrexate and calcipotriol, its potential disadvantages, including loss of response in some patients, drug-related adverse events and particularly high cost, have motivated chemists and researchers to shift towards its biosimilar, CT-P13. CT-P13 has a better tolerance and much less cost, attracting more attention. Here, we summarize the clinical findings of CT-P13 from clinical trials in various diseases.

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“…Без сомнения, адекватные и дозированные физические нагрузки полезны для здоровья человека и состояния сердечно-сосудистой системы. Физическая активность уменьшает окислительный стресс в сосуде, модифицирует липидный профиль, ингибирует выработку макрофагами и моноцитами провоспалительного цитокина TNFα [20,21]. Активная пропаганда здорового образа жизни, а главное -доходность сектора фитнес-услуг способствуют увеличению числа лиц, посещающих тренажерные залы и фитнес-клубы [22].…”

Section: Introductionunclassified

The role of physical activity in the development of atherosclerotic lesions of the vascular wall

Markin¹,

Markina²,

Sukhorukov³

et al. 2019

Clin. Exp. Morphology

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1 ФГБНУ Научно-исследовательский институт морфологии человека, Москва, Россия 2 ФГБУ Национальный медицинский исследовательский центр кардиологии Минздрава России, Москва, Россия 3 ФГБНУ Научно-исследовательский институт общей патологии и патофизиологии, Москва, Россия 4 Институт исследований атеросклероза, Сколковский инновационный центр, Москва, Россия В обзоре рассматриваются основные механизмы повреждающего действия чрезмерных физических нагрузок на клеточные структуры эндотелия сосудов и развития связанных с этим процессом системных патологических состояний. Общепринятое мнение о пользе физической активности для профилактики сердечно-сосудистых заболеваний не подвергается сомнению. Тем не менее сегодня широкое распространение получили различные тренировочные программы с дискуссионным соотношением пользы и вреда. Отличительными чертами такого типа физической активности являются высокая степень интенсивности физической нагрузки и большие тренировочные объемы. Нарушение режимов тренировки и отдыха при таком подходе к тренировкам часто приводит к развитию синдрома перетренированности. Понимание причин развития данного состояния на молекулярном и клеточном уровне позволит повысить эффективность планирования тренировочного процесса у соревнующихся атлетов и продлить спортивное долголетие пожилым спортсменам и любителям спорта. Ключевые слова: атеросклероз, воспаление, чрезмерные физические нагрузки, артериальная ригидность. Для корреспонденции: Александр Михайлович Маркин. Финансирование. Исследование выполнено при поддержке Российского научного фонда (грант № 19-15-00010). Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.The main mechanisms of the damaging effect of excessive physical exertion on the cellular structures of the vascular endothelium and the development of systemic pathological conditions associated with this process are covered in this paper. The generally accepted view on the benefits of physical activity for the prevention of cardiovascular disease is not in doubt. However, today various training programs of debatable benefits and risks ratio are widely used. High intensity high volume training is the distinctive feature of this type of physical activity. Violation of the training and rest schedules in this approach often leads to the overtraining syndrome. Understanding the causes of this condition at the molecular and cellular levels may increase the efficiency of training planning for competing athletes and prolong sport participation of the elderly athletes and sports enthusiasts.

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TNF-α in the cardiovascular system: from physiology to therapy

Cited by 70 publications

References 205 publications

Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Clinical Benefits of Switching from Original Infliximab to its Biosimilar (CT-P13) as a Potential TNF-α Inhibitor

The role of physical activity in the development of atherosclerotic lesions of the vascular wall

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