TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria

Kwiatkowski, Dominic P.; Hill, Adrian V. S.; Sambou, I; Twumasi, Patrick; Castracane, J.; Manogue, Kirk R.; Cerami, Anthony; Brewster, David; Greenwood, Brian

doi:10.1016/0140-6736(90)92827-5

Cited by 798 publications

(571 citation statements)

References 16 publications

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“…Severe, life-threatening malaria caused by P. falciparum has been linked to the release of pro-inflammatory cytokines, especially tumour necrosis factor (TNF) [40][41][42][43]. The basis of adult susceptibility to severe disease caused by primary infection with P. falciparum may lie in the production of inordinately high levels of pro-inflammatory cytokines like TNF.…”

Section: Discussionmentioning

confidence: 99%

Adult Javanese migrants to Indonesian Papua at high risk of severe disease caused by malaria

Baird¹,

Basri

Weina³

et al. 2003

Epidemiol. Infect.

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Migrants from Java arrive in hyperendemic Papua, Indonesia lacking exposure to endemic malaria. We evaluated records of evacuation to hospital with a diagnosis of severe malaria from a transmigration village in northeastern Papua. During the first 30 months, 198 residents with severe disease were evacuated (7·5 evacuations/100 person-years). During this period the risk of evacuation for adults (>15 years of age) was 2·8. (95% CI=2·1–3·8; P<0·0001) relative to children, despite apparently equal exposure to risk of infection. Relative risk (RR) for adults was greatest during the first 6 months (RR>16; 95% CI[ges ]2·0–129; P=0·0009), and diminished during the second 6 months (RR=9·4; 95% CI=2·7–32·8; P<0·0001) and the third 6 months (RR=3·7; 95% CI=1·7–7·9; P=0·0004). During the next two 6-month intervals, the RR for adults was 1·6 and 1·5 (95% CI range 0·8–2·6; P<0·18). Adults lacking chronic exposure were far more likely to progress to severe disease compared to children during initial exposure, but not after chronic exposure to infection.

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Section: Discussionmentioning

confidence: 99%

Adult Javanese migrants to Indonesian Papua at high risk of severe disease caused by malaria

Baird¹,

Basri

Weina³

et al. 2003

Epidemiol. Infect.

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“…34 Although haplotype 2 itself is not associated with RA, these findings suggest the possibility therefore that overexpression of BAT1 may play a role in susceptibility to RA as well as systemic lupus erythematosus (SLE) nephritis. It is somewhat surprising that high TNF mRNA levels were found to be associated with haplotype 2 and not the ancestral haplotype 1 as might be expected from both human 35,36 and in vitro studies. 37 The magnitude of this difference was only 1.3 above the mean and therefore may not be biologically significant.…”

Section: Gene Expression Analysis Of the Telomeric Mhc D Mewar Et Almentioning

confidence: 87%

Haplotype-specific gene expression profiles in a telomeric major histocompatibility complex gene cluster and susceptibility to autoimmune diseases

et al. 2006

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The telomeric class III region of the major histocompatibility complex is gene dense, but apart from the three tumour necrosis factor (TNF) superfamily members (TNF, lymphotoxin alpha and lymphotoxin beta) little is known of the expression and function of the majority of the genes. Recent genetic studies in autoimmune diseases, particularly rheumatoid arthritis (RA), have suggested a human leukocyte antigen (HLA)-DR-independent disease effect in this region. To gain further insights into these associations, we used lipopolysaccharide-stimulated human macrophages to examine inducible mRNA expression and genotype-phenotype relationships for genes in this region. Following stimulation in addition to the expected induction of TNF mRNA, a 14-fold increase of ATP6V1G2 at 18 h (Po0.001) was seen, whereas B-associated transcript (BAT)2 (Po0.001) and leucocyte-specific transcript (LST)1 (Po0.001) were both downregulated. By genotyping single-nucleotide polymorphisms spanning a 70 kb interval centred on the TNF locus, we constructed haplotypes and determined associated expression profiles for 10 genes in the cluster using quantitative real-time polymerase chain reaction. Overexpression of BAT1 mRNA was associated with carriers of a haplotype containing the LST1 marker transmitted to RA cases in a family study and also DRB1*15 associated with susceptibility to nephritis in systemic lupus erythematosus. The implications of our findings for the understanding of genetic associations with disease susceptibility in this region are discussed.

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“…Evidence has accumulated that whereas moderate production of TNF might help to eradicate Babesia and Plasmodium spp. parasitemia, excessive production of TNF and related proinflammatory cytokines is primarily responsible for symptoms associated with these infections [24,26,[29][30][31][32][33][34][35].…”

Section: Moderate Diseasementioning

confidence: 99%

“…TNF has been shown to upregulate ICAM-1 and VCAM-1 endothelial cell surface molecules, which might serve as receptors for leukocytes and P. falciparum-infected erythrocytes. Elevated TNF blood concentrations have been associated with lethal outcomes in children who have cerebral malaria [32]. TNF and upregulated endothelial surface molecules have been demonstrated in post-mortem brain tissue in 14 Ghanian children who died of malaria, and a child who died from salmonella septicemia and malaria co-infection [55].…”

Section: Central Nervous System Complicationsmentioning

confidence: 99%

Shared features in the pathobiology of babesiosis and malaria

Krause

Daily

Telford

et al. 2007

Trends in Parasitology

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TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria

Cited by 798 publications

References 16 publications

Adult Javanese migrants to Indonesian Papua at high risk of severe disease caused by malaria

Adult Javanese migrants to Indonesian Papua at high risk of severe disease caused by malaria

Haplotype-specific gene expression profiles in a telomeric major histocompatibility complex gene cluster and susceptibility to autoimmune diseases

Shared features in the pathobiology of babesiosis and malaria

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