TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex

Yli-Karjanmaa, Minna; Larsen, Kathrine Solevad; Fenger, Christina; Kristensen, Lotte K.; Martin, Nellie Anne; jensen, Peter Toft; Breton, Alexandre; Nathanson, Lubov; Nielsen, Pernille Vinther; Lund, Minna Christiansen; Carlsen, Stephanie Lindeman; Gramsbergen, Jan Bert; Finsen, Bente; Stubbe, Jane; Frich, Lars Henrik; Stolp, Helen B.; Brambilla, Roberta; Anthony, Daniel C.; Meyer, Morten; Lambertsen, Kate Lykke

doi:10.1016/j.bbi.2019.08.195

Cited by 29 publications

(15 citation statements)

References 120 publications

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“…In support of the neuromodulatory role of microglial derived TNF-α, it has recently been shown that the long-term inhibition of TNF-α with the nonselective TNF-α inhibitor etanercept impairs learning and memory after two months of treatment [90]. It also decreased adult neurogenesis (see below).…”

Section: Role Of Microglia In Homeostatic Functions and Cognitive mentioning

confidence: 99%

What Do Microglia Really Do in Healthy Adult Brain?

Augusto-Oliveira

Arrifano

Lopes-Araújo

et al. 2019

Cells

118

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Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood without replacement by bone marrow-derived circulating cells. In inflammation, stroke, aging, or infection, microglia have been shown to contribute to brain pathology in both deleterious and beneficial ways, which have been studied extensively. However, less is known about their role in the healthy adult brain. Astrocytes and oligodendrocytes are widely accepted to strongly contribute to the maintenance of brain homeostasis and to modulate neuronal function. On the other hand, contribution of microglia to cognition and behavior is only beginning to be understood. The ability to probe their function has become possible using microglial depletion assays and conditional mutants. Studies have shown that the absence of microglia results in cognitive and learning deficits in rodents during development, but this effect is less pronounced in adults. However, evidence suggests that microglia play a role in cognition and learning in adulthood and, at a cellular level, may modulate adult neurogenesis. This review presents the case for repositioning microglia as key contributors to the maintenance of homeostasis and cognitive processes in the healthy adult brain, in addition to their classical role as sentinels coordinating the neuroinflammatory response to tissue damage and disease.

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Section: Role Of Microglia In Homeostatic Functions and Cognitive mentioning

confidence: 99%

What Do Microglia Really Do in Healthy Adult Brain?

Augusto-Oliveira

Arrifano

Lopes-Araújo

et al. 2019

Cells

118

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“…Unlike other non-selective TNF-α inhibitors, XPro1595 does not suppress innate immunity or myelination mediated by type 2 receptors (236). Differently from etanercept, longterm treatment with XPro1595 does not suppress hippocampal neurogenesis, learning, and memory in adult mice (237). In 5xFAD mice, twice-weekly subcutaneous administration of XPro1595 for 2 months reduced brain amyloid deposition and immune cell infiltration, and improved synaptic function (238).…”

Section: Stage-dependent Neuroinflammatory Process In the Alzheimer'smentioning

confidence: 99%

A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease

et al. 2020

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“…Furthermore, it is known that inflammatory stimuli can alter synaptic plasticity, leading to aberrant synaptic depression or potentiation, based on the type of the stimulus (Costello et al, 2011;Pascual et al, 2012;Zhang et al, 2014). In this way, microglia and their secreted cytokines can have a direct impact on CNS development, learning, and memory (Depino et al, 2004;Yli-Karjanmaa et al, 2019).…”

Section: Role Of Microglia-derived Evs In the Central Nervous Systemmentioning

confidence: 99%

Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease

Pistono

Bister

Stanová

et al. 2021

Front. Cell Dev. Biol.

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Glial cells are crucial for the maintenance of correct neuronal functionality in a physiological state and intervene to restore the equilibrium when environmental or pathological conditions challenge central nervous system homeostasis. The communication between glial cells and neurons is essential and extracellular vesicles (EVs) take part in this function by transporting a plethora of molecules with the capacity to influence the function of the recipient cells. EVs, including exosomes and microvesicles, are a heterogeneous group of biogenetically distinct double membrane-enclosed vesicles. Once released from the cell, these two types of vesicles are difficult to discern, thus we will call them with the general term of EVs. This review is focused on the EVs secreted by astrocytes, oligodendrocytes and microglia, aiming to shed light on their influence on neurons and on the overall homeostasis of the central nervous system functions. We collect evidence on neuroprotective and homeostatic effects of glial EVs, including neuronal plasticity. On the other hand, current knowledge of the detrimental effects of the EVs in pathological conditions is addressed. Finally, we propose directions for future studies and we evaluate the potential of EVs as a therapeutic treatment for neurological disorders.

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TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex

Cited by 29 publications

References 120 publications

What Do Microglia Really Do in Healthy Adult Brain?

What Do Microglia Really Do in Healthy Adult Brain?

A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease

Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease

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