Cancer Discovery
 2022
DOI: 10.1158/2159-8290.cd-22-1022
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TNF Receptors Choose HSC Fate in SupportingDnmt3a-Mutant Clonal Hematopoiesis

Katia E. Niño
1
,
Eric M. Pietras
2

Abstract: Summary: TNFα receptor signaling distinctly promotes self-renewal and lymphoid differentiation in Dnmt3a-mutant hematopoietic stem cells, contributing to clonal hematopoiesis of indeterminate potential. See related article by SanMiguel et al., p. 2763 (3).

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