TNF-related apoptosis-inducing ligand, interferon gamma-induced protein 10, and C-reactive protein in predicting the progression of SARS-CoV-2 infection: a prospective cohort study

Interferon gamma-induced protein 10 (IP-10) for the early prognosis of the risk for severe respiratory failure and death in COVID-19 pneumonia

“…Our results are in alignment with previous studies reporting that low TRAIL concentrations are associated with severe disease [21] . Nonetheless due to the high baseline severity of this cohort, the biomarker was nonspecific, and therefore, was not associated with progression to SRF or death compared to recovered patients [22] .…”

Multiomics single timepoint measurements to predict severe COVID-19 – Authors' reply

“…Tegethoff and colleagues also advocate repeated measurements during the course of the disease; however, we do not think these additional timepoints would affect the predictive value of biomarkers from samples collected at baseline, which was the primary goal of our study. Finally, we are happy that our baseline study showed a positive association of C-X-C motif chemokines 10 with severe COVID-19, similar to that observed by Tegethoff and colleagues 5 during a longer timeframe. Overall, we agree that the path from discovery studies to clinical deployment involves several steps including further testing and validation, as noted both in our study 1 and by Tegethoff and colleagues.…”

Multiomics single timepoint measurements to predict severe COVID-19

“…Thus, feasibility and cost-effectiveness are relevant issues that could potentially be overcome by point-of-care tests. 2 Finally, we are pleased to see that the positive association we found 3 of C-X-C motif chemokines 10 (also known as interferon γ-induced protein 10) with severe COVID-19 was also shown in Byeon and colleagues’ study. 1 We concur that future, prospective studies are warranted to validate the predictive value of biomarkers of COVID-19 severity on a large scale and to evaluate their clinical impact.…”