TNF superfamily gene polymorphism as prognostic factor in early breast cancer

Jung, Jin Hyang; Chae, Yee Soo; Moon, Joon Ho; Kang, Byung Woog; Kim, Jong Gwang; Sohn, Sang Kyun; Park, Ji Young; Lee, Myung Hoon; Park, Ho Yong

doi:10.1007/s00432-009-0707-0

Cited by 19 publications

(15 citation statements)

References 34 publications

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“…This speculation agrees with findings from direct studies on FASL expression in breast cancer showing that FASL did not influence patient outcome [13]. Our findings are also consistent with those of Jung et al showing that FASLÀ844 T/C polymorphism had no prognostic effect on survival in patients with early breast cancer [43]. Moreover, no evidence of association of this polymorphism with DFS was reported in Caucasian patients with breast cancer [44].…”

Section: Discussionsupporting

confidence: 94%

FASL−844 T/C polymorphism: A biomarker of good prognosis of breast cancer in the Tunisian population

et al. 2012

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Section: Discussionsupporting

confidence: 94%

FASL−844 T/C polymorphism: A biomarker of good prognosis of breast cancer in the Tunisian population

et al. 2012

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“…We also found that the TT genotype at nucleotide 1595 in TRAIL engendered a lower risk of FLD and a less severe form of steatosis in FLD patients in a Chinese population (Yan et al, 2009). Recently, the TRAIL SNP rs1131532 was identified as a possible prognostic factor for survival in patients operated on for invasive breast cancer (Jung et al, 2010). In addition, a promoter SNP in TRAIL was shown to functionally modulate the role of TRAIL in breast cancer pathogenesis (Pal et al, 2011).…”

Section: Discussionmentioning

confidence: 78%

Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population

Yu¹,

Zhao²,

Yan³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including the pancreas and lymphocytes, and it can selectively induce apoptosis in tumor cells but not in most normal cells. TRAIL plays critical roles in type 1 diabetes mellitus, and is involved in type 2 diabetes mellitus (T2DM). We recently discovered the association of nonalcoholic fatty liver disease, a risk factor for T2DM, with a single nucleotide polymorphism (SNP) in the TRAIL (TNFSF10) gene at site 1595C/T (rs1131580), indicating the possible association of T2DM with this TRAIL polymorphism. The aim of this study was to investigate the relationship of the TRAIL SNP at site 1595C/T (rs1131580) with T2DM susceptibility and the biometabolic parameters of T2DM in a Han Chinese population. The polymerase chain reaction-restriction fragment length polymorphism method was used to genotype SNP rs1131580 in 292 patients with T2DM and 266 healthy controls. We found that the frequency of the CC genotype and that of the C allele of rs1131580 were significantly higher in T2DM patients than in the control group. Additionally, the triglyceride and serum creatinine levels of T2DM patients with the CC genotype were significantly higher than those of patients with the TT genotype. Thus, the CC genotype of the TRAIL SNP at 1595C/T (rs1131580) confers increased susceptible to T2DM in a Han Chinese population from Shandong Province. These data suggest that the CC genotype at this SNP is related to diabetic severity and it might be a candidate for the prognostic assessment of T2DM.

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“…Here we show an association between T4EM lymphocytes radiosensitivity and three SNPs within the TRAIL/TNFSF10- gene. Interestingly, these same SNPs were associated with risk and/or treatment outcome in ovarian and breast cancer [24-26]. Further investigation is now needed to understand if and/or how these genetic variants influence TRAIL/TNFSF10 mRNA level.…”

Section: Discussionmentioning

confidence: 99%

TNFSF10/TRAIL regulates human T4 effector memory lymphocyte radiosensitivity and predicts radiation-induced acute and subacute dermatitis

et al. 2016

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Sensitivity of T4 effector-memory (T4EM) lymphocytes to radiation-induced apoptosis shows heritability compatible with a Mendelian mode of transmission. Using gene expression studies and flow cytometry, we show a higher TNF-Related Apoptosis Inducing Ligand (TRAIL/TNFSF10) mRNA level and a higher level of membrane bound TRAIL (mTRAIL) on radiosensitive compared to radioresistant T4EM lymphocytes. Functionally, we show that mTRAIL mediates a pro-apoptotic autocrine signaling after irradiation of T4EM lymphocytes linking mTRAIL expression to T4EM radiosensitivity. Using single marker and multimarker Family-Based Association Testing, we identified 3 SNPs in the TRAIL gene that are significantly associated with T4EM lymphocytes radiosensitivity. Among these 3 SNPs, two are also associated with acute and subacute dermatitis after radiotherapy in breast cancer indicating that T4EM lymphocytes radiosensitivity may be used to predict response to radiotherapy. Altogether, these results show that mTRAIL level regulates the response of T4EM lymphocytes to ionizing radiation and suggest that TRAIL/TNFSF10 genetic variants hold promise as markers of individual radiosensitivity.

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TNF superfamily gene polymorphism as prognostic factor in early breast cancer

Abstract: The TNFSF10 (rs1131532) polymorphism was identified as a possible prognostic factor of survival in patients with operated invasive breast cancer.

Cited by 19 publications

References 34 publications

FASL−844 T/C polymorphism: A biomarker of good prognosis of breast cancer in the Tunisian population

FASL−844 T/C polymorphism: A biomarker of good prognosis of breast cancer in the Tunisian population

Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population

TNFSF10/TRAIL regulates human T4 effector memory lymphocyte radiosensitivity and predicts radiation-induced acute and subacute dermatitis

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